抗BMP Receptor ⅠB抗体(Anti-BMP Receptor ⅠB, Human, Goat-Poly antibody)

• 価格
• Product Details
• Applications and Data
• Related Product & Information
• Citations

価格

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Product Details

Species Reactivity	Human
Label	Unconjugated
Immunogen	Mouse myeloma cell line NS0-derived recombinant human BMPR-IB/ALK-6Lys14-Arg126Accession # O00238
Source	Polyclonal Goat IgG
Purification	Antigen Affinity-purified
Specificity	Detects human BMPR-IB in direct ELISAs and Western blots. In direct ELISAs, approximately 50% cross-reactivity with recombinant mouse BMPR‑IB is observed and less than 1% cross-reactivity with recombinant human (rh) BMPR-IA and rhBMPR-II is observed.

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Applications and Data

	Recommended Concentration	Sample
Western Blot	0.1 µg/mL	Recombinant Human BMPR-IB/ALK‑6 Fc Chimera (Catalog # 505-PR)

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Related Product & Information

Background

BMPR-IB/ALK-6

background_content

Background: BMPR-IB/ALK-6 Cellular responses to bone morphogenetic proteins (BMPs) have been shown to be mediated by the formation of hetero-oligomeric complexes of the type I and type II serine/threonine kinase receptors. BMP receptor IB (BMPR-IB), also known as activin receptor-like kinase (ALK)-6, is a one of seven known type I serine/threonine kinases that are required for the signal transduction of TGF-beta family cytokines. In contrast to the TGF-beta receptor system in which the type I receptor does not bind TGF-beta  in the absence of the type II receptor, type I receptors involved in BMP signaling (including BMPR-IA, BMPR-IB/ALK-6, and ActR-I/ALK-2) can independently bind the various BMP family proteins in the absence of type II receptors. Recombinant soluble BMPR-IB binds BMP-4 with high-affinity in solution and is a potent BMP-4 antagonist in vitro. BMPR-IB is expressed in various tissues during embryogenesis. In adult tissues, BMPR-IB is only found in the brain. The extracellular domain of BMPR-IB shares little amino acid sequence identity with the other mammalian ALK type I receptor kinases, but the cysteine residues are conserved. Human and mouse BMPR-IB are highly conserved and share 98% sequence identity.

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Citations

1. BMP4 inhibits breast cancer metastasis by blocking myeloid-derived suppressor cell activity.
   Authors: Cao Y, Slaney C, Bidwell B, Parker B, Johnstone C, Rautela J, Eckhardt B, Anderson R
   Cancer Res, 2014;74(18):5091-102.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


2. Bone morphogenetic protein-9 activates Smad and ERK pathways and supports human osteoclast function and survival in vitro.
   Authors: Fong D, Bisson M, Laberge G, McManus S, Grenier G, Faucheux N, Roux S
   Cell Signal, 2013;25(4):717-28.
   Species: Human
   Sample Type: Cell Lysates
   Application: WB


3. Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells.
   Authors: Lee J, Son MJ, Woolard K, Donin NM, Li A, Cheng CH, Kotliarova S, Kotliarov Y, Walling J, Ahn S, Kim M, Totonchy M, Cusack T, Ene C, Ma H, Su Q, Zenklusen JC, Zhang W, Maric D, Fine HA
   Cancer Cell, 2008;13(1):69-80.
   Species: Human
   Sample Type: Cell Lysates
   Application: WB


4. Sequential roles for myosin-X in BMP6-dependent filopodial extension, migration, and activation of BMP receptors.
   Authors: Pi X, Ren R, Kelley R, Zhang C, Moser M, Bohil AB, Divito M, Cheney RE, Patterson C
   J. Cell Biol., 2007;179(7):1569-82.
   Species: Mouse
   Sample Type: Cell Lysates
   Application: IP

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