抗TrkB抗体(Anti-TrkB, Human, Goat-Poly antibody)
掲載日情報:2018/11/26 現在Webページ番号:26973
TrkBに対する抗体(Anti-TrkB, Human, Goat-Poly )です。
※ 本製品は研究用です。研究用以外には使用できません。
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価格
[在庫・価格 :2025年05月01日 09時15分現在]
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Anti-Human TrkB Affinity Purified Polyclonal Ab |
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[在庫・価格 :2025年05月01日 09時15分現在]
Anti-TrkB, Human, Goat-Poly
文献数: 3
- 商品コード:AF397
- メーカー:RSD
- 包装:100μg
- 価格:¥104,000
- 在庫:無(未発注)
- 納期:10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
Anti-Human TrkB Affinity Purified Polyclonal Ab
文献数: 0
- 商品コード:AF397-SP
- メーカー:RSD
- 包装:25μg
- 価格:¥30,000
- 在庫:無(未発注)
- 納期:2~3週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
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Product Details
Species Reactivity | Human |
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Label | Unconjugated |
Immunogen | Mouse myeloma cell line NS0-derived recombinant human TrkB |
Source | Polyclonal Goat IgG |
Purification | Antigen Affinity-purified |
Specificity | Detects human TrkB in direct ELISA and Western blots. In direct ELISA and Western blots, less than 1% cross-reactivity with recombinant human (rh) TrkC, rhNT‑3, rhNT‑4, rhBDNF, and rh beta ‑NGF is observed. |
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Applications and Data
Recommended Concentration | Sample | |
Western Blot | 0.5 µg/mL | See below |
Simple Western | 10 µg/mL | See below |
Flow Cytometry | 2.5 µg/106 cells | Human TrkB transfected C6 cells |
CyTOF-ready | Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation. |
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Related Product & Information
Background | TrkB |
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background_content | Background: TrkB The neurotrophins, including NGF, BDNF, NT-3, and NT-4/5 constitute a group of structurally related, secreted proteins that play an important role in the development and function of the nervous system. The biological activities of the neurotrophins are mediated by binding to the different members of the Trk family tyrosine kinase receptors. Three Trk family proteins, TrkA, TrkB, and TrkC, exhibiting different ligand specificities, have been identified. TrkA binds NGF, TrkB binds BDNF and NT-4/5 and TrkC binds NT-3. All Trk family proteins share a conserved complex subdomain organization consisting of a signal peptide, two cysteine-rich domains, a cluster of three leucine-rich motifs, and two immunoglobulin-like domains in the extracellular region, as well as an intracellular region that contains the tyrosine kinase domain. Natural splice variants of the different Trks, including TrkB variants lacking the first cysteine-rich domain, the first and second or all three of the leucine-rich motifs, or the tyrosine kinase domain, have been described. The role of the different extracellular subdomains of TrkB in mediating neurotrophin binding and discrimination is currently being investigated. At the protein sequence level, human and rat TrkB are greater than 90% identical and the proteins exhibit cross-species activity. TrkB is primarily expressed in the nervous system. However, low levels of TrkB expression have also been observed in a wide variety of tissues (pancreas, kidneys, ovary) outside the nervous system. |
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Citations
- Constitutively active TrkB confers an aggressive transformed phenotype to a neural crest-derived cell line.
Authors: Dewitt J, Ochoa V, Urschitz J, Elston M, Moisyadi S, Nishi R
Oncogene, 2014;33(8):977-85.
Species: Human
Sample Type: Cell Lysates
Application: WB - Protein tyrosine phosphatase receptor type O inhibits trigeminal axon growth and branching by repressing TrkB and Ret signaling.
Authors: Gatto G, Dudanova I, Suetterlin P, Davies A, Drescher U, Bixby J, Klein R
J Neurosci, 2013;33(12):5399-410.
Species: Human
Sample Type: Cell Lysates
Application: WB
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