抗CD40 Ligand抗体(Anti-CD40 Ligand, Mouse, Goat-Poly antibody)
掲載日情報:2019/10/21 現在Webページ番号:26789
CD40 Ligandに対する抗体(Anti-CD40 Ligand, Mouse, Goat-Poly )です。
※ 本製品は研究用です。研究用以外には使用できません。
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価格
[在庫・価格 :2025年07月07日 13時55分現在]
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Anti-CD40 Ligand, Mouse, Goat-Poly |
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Anti-Mouse CD40 Ligand/TNFSF5 Affinity Purified Polyclonal Ab |
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[在庫・価格 :2025年07月07日 13時55分現在]
Anti-CD40 Ligand, Mouse, Goat-Poly
文献数: 8
- 商品コード:AF1163
- メーカー:RSD
- 包装:100μg
- 価格:¥83,000
- 在庫:無(未発注)
- 納期:10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
説明文 | サンドイッチELISAで,#BAF1163抗体(RSD社)と共に用いる際,捕捉用抗体として利用できる。 別名:CD154 Genbank No: 959 Protein Accession No: P27548 |
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別包装品 | 別包装品あり | ||||||
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保存条件 | -20℃ | 法規備考 | |||||
抗原種 | Mouse | 免疫動物 | Goat | ||||
交差性 | Mouse | 適用 | IC,Neutralising,Western Blot | ||||
標識 | Unlabeled | 性状 | Antigen Affinity Purified | ||||
吸収処理 | クラス | IgG | |||||
クロナリティ | Polyclonal | フォーマット | |||||
掲載カタログ |
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製品記事 | |||||||
関連記事 |
Anti-Mouse CD40 Ligand/TNFSF5 Affinity Purified Polyclonal Ab
文献数: 1
- 商品コード:AF1163-SP
- メーカー:RSD
- 包装:25μg
- 価格:¥30,000
- 在庫:無(未発注)
- 納期:2~3週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
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Product Details
Species Reactivity | Mouse |
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Label | Unconjugated |
Immunogen | Mouse myeloma cell line NS0-derived recombinant mouse CD40 Ligand/TNFSF5Glu61-Leu260Accession # P27548 |
Source | Polyclonal Goat IgG |
Purification | Antigen Affinity-purified |
Specificity | Detects mouse CD40 Ligand/TNFSF5 in Western blots. |
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Applications and Data
Recommended Concentration | Sample | |
Western Blot | 0.1 µg/mL | Recombinant Mouse CD40 Ligand/TNFSF5 (Catalog # 1163-CL) |
Immunocytochemistry | 5-15 µg/mL | See below |
Neutralization | Measured by its ability to neutralize CD40 Ligand/TNFSF5-induced proliferation in mouse splenic B cells. The Neutralization Dose (ND50) is typically 0.08-0.4 µg/mL in the presence of 0.5 ng/mL Recombinant Mouse CD40 Ligand/TNFSF5. |
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Related Product & Information
Entrez Gene IDs | 959 (Human); 21947 (Mouse); 84349 (Rat) |
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Background | CD40 Ligand/TNFSF5 |
background_content | Background: CD40 Ligand/TNFSF5 CD40 ligand (CD40L), also known as CD154, TNFSF5, TRAP or gp39, is a 260 amino acid (aa) type II transmembrane glycoprotein belonging to the TNF family. Murine CD40L consists of a 22 aa cytoplasmic domain, a 24 aa transmembrane domain, and 214 aa extracellular domain bearing a single glycosylation site (1, 2). CD40L is expressed predominantly on activated CD4+ T lymphocytes, and also found in other types of cells, including NK cells, mast cells, basophils and eosinophils. Murine CD40L shares 78% amino acid sequence identity with human CD40L. Native bioactive soluble CD40L exists. Soluble human trimeric CD40L secreted by stimulated T cells has been shown to be generated by proteolysis in the microsomes (3). Both membrane bound and soluble CD40L induce similar effects on B cells (3, 4). The receptor of CD40L is CD40, a type I transmembrane glycoprotein belonging to the TNF receptor family. CD40 is expressed on B lymphocytes, monocytes, dendritic cells, and thymic epithelium. Although all monomeric, dimeric and trimeric forms of soluble CD40L can bind to CD40, the soluble trimeric form of CD40L has the most potent biological activity through oligomerization of cell surface CD40, a common feature of TNF receptor family members (2). The genetic defect in the hyper-IgM syndrome is due to point mutations or deletions of the gene encoding the CD40L, which prevent CD40L from interacting with CD40 (5-7). CD40L mediates a range of activities on B cells including induction of activation-associated surface antigen, entry into the cell cycle, isotype switching, Ig secretion, and memory generation (8, 9). CD40-CD40L interaction also plays important roles in monocyte activation and dendritic cell maturation (10). |
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Citations
- Vaccination with a fusion protein that introduces HIV-1 gag antigen into a multitrimer CD40L construct results in enhanced CD8+ T cell responses and protection from viral challenge by vaccinia-gag.
Authors: Gupta, Sachin, Termini, James M, Raffa, Francesc, Williams, Cindi-An, Kornbluth, Richard, Stone, Geoffrey
J Virol, 2014;88(3):1492-501.
Species: Mouse
Sample Type: Cell Culture Supernates
Application: WB - The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.
Authors: Akiyama T, Shimo Y, Yanai H, Qin J, Ohshima D, Maruyama Y, Asaumi Y, Kitazawa J, Takayanagi H, Penninger JM, Matsumoto M, Nitta T, Takahama Y, Inoue J
Immunity, 2008;29(3):423-37.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC Paraffin-embedded - CD40L expressed from the canarypox vector, ALVAC, can boost immunogenicity of HIV-1 canarypox vaccine in mice and enhance the in vitro expansion of viral specific CD8+ T cell memory responses from HIV-1-infected and HIV-1-uninfected individuals.
Authors: Liu J, Yu Q, Stone GW, Yue FY, Ngai N, Jones RB, Kornbluth RS, Ostrowski MA
Vaccine, 2008;26(32):4062-72.
Species: Mouse
Sample Type: Recombinant Protein
Application: WB - Preformed CD40 ligand exists in secretory lysosomes in effector and memory CD4+ T cells and is quickly expressed on the cell surface in an antigen-specific manner.
Authors: Koguchi Y, Thauland TJ, Slifka MK, Parker DC
Blood, 2007;110(7):2520-7.
Species: Mouse
Sample Type: Whole Cells
Application: ICC - Reduced pathology following infection with transgenic Leishmania major expressing murine CD40 ligand.
Authors: Field AE, Wagage S, Conrad SM
Infect. Immun., 2007;75(6):3140-9.
Species: Human
Sample Type: Cell Culture Supernates
Application: ELISA Development
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