抗Protocadherin Gamma C3モノクローナル抗体(Anti-Protocadherin Gamma C3) Protocadherin Gamma C3 antibody (S174B-27:クローン名) | StressMarq Biosciences

Protocadherin Gamma C3 Antibody

Monoclonal

Anti-Protocadherin Gamma C3

Neuroscience

PCDHGC3, Cadherin like 2, PC 43, PC43, PCDH 2, PCDH gamma C3, PCDH2, PCDHGC 3, Protocadherin 2, Protocadherin 43, Protocadherin gamma C3, Protocadherin gamma subfamily C 3, Protocadherin2, Protocadherin43, Pcdhgb6

S174B-27

Mouse

IgG1

Fusion protein amino acids 720-804 (variable cytoplasmic domain) of mouse Gamma- protocadherin-C3 (Accession no. Q91XX1) Human: 97% identity (83/85 amino acids identical) Rat: 97% identity (83/85 amino acids identical) No significant identity with othe

WB, ICC

Mouse

Q91XX1

93706

Q91XX1

Detects a 100 kDa protein.

1:1000 WB

Protein G Purified

PBS pH 7.4, 50% glycerol, 0.1% sodium azide

Research Background
This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. PCDHGC3 is a potential calcium-dependent cell-adhesion protein. It may be involved in the establishment and maintenance of specific neuronal connections in the brain. This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains

3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.