抗PD-L1, Rabbit-Mono(OR-5E3) TrueMAB抗体 | Anti-PD-L1, Rabbit-Mono(OR-5E3) TrueMAB Antibody

• 価格
• 特長
• 使用例
• 製品情報

価格

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特長

TrueMAB抗体について
OriGene社抗体製品の中でも特にTrueMAB 抗体シリーズは、三次元構造を有する組換え体ヒトタンパク質の全長を抗原として作製したモノクローナル抗体です。そのため、立体構造を持たない短鎖ペプチドを抗原として作製した抗体では検出が困難なエピトープも認識でき、ネイティブなタンパク質への特異性が向上しています。

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使用例

	Immunohistochemical staining of FFPE human placenta with Rb monoclonal PD-L1 C/N TA591004 clone OR-5E3 at 1:100. Rb anti-PD-L1 clone OR-5E3 requires heat-induced epitope retrieval (HIER) at 120C for 3min with ACCEL (EDTA-Tris pH8.7). Detection was done with Polink2 polymer detection system and visualized with DAB. Strong membrane staining seen in trophoblasts.
	Immunohistochemical staining of FFPE human melanoma with Rb monoclonal PD-L1 C/N TA591004 clone OR-5E3 at 1:100. Rb anti-PD-L1 clone OR-5E3 requires heat-induced epitope retrieval (HIER) at 120C for 3min with ACCEL (EDTA-Tris pH8.7). Detection was done with Polink2 polymer detection system and visualized with DAB. Strong membrane staining seen in tumor cells.
	Immunohistochemical staining of FFPE human lung cancer case 1 with Rb monoclonal PD-L1 C/N TA591004 clone OR-5E3 at 1:100. Rb anti-PD-L1 clone OR-5E3 requires heat-induced epitope retrieval (HIER) at 120C for 3min with ACCEL (EDTA-Tris pH8.7). Detection was done with Polink2 polymer detection system and visualized with DAB. Strong membrane staining seen in tumor cells.
	Immunohistochemical staining of FFPE human lung cancer case 2 with Rb monoclonal PD-L1 C/N TA591004 clone OR-5E3 at 1:100. Rb anti-PD-L1 clone OR-5E3 requires heat-induced epitope retrieval (HIER) at 120C for 3min with ACCEL (EDTA-Tris pH8.7). Detection was done with Polink2 polymer detection system and visualized with DAB. Strong membrane staining seen in tumor cells.

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製品情報

Clone Name	OR-5E3
Applications	IHC
Recommend Dilution	IHC 1:50-1:200
Reactivity	Human
Host	Rabbit
Clonality	Monoclonal
Immunogen	Synthetic peptide within Human PD-L1 C-terminal. The exact sequence is proprietary.
Isotype	IgG
Formulation	Tissue culture buffer containing 1% BSA and 0.02% Sodium azide
Purification	Tissue culture supernatant
Predicted Protein Size	34 KDa
Gene Name	CD274 molecule
Background	This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Synonyms	B7-H|B7H1|PD-L1|PDCD1L1|PDCD1LG1|PDL1
Database Link	NP_054862 Entrez Gene 29126 HumanEntrez Gene 0 MouseEntrez Gene 0 RatEntrez Gene 0 MonkeyEntrez Gene 0 Dog

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