抗p38 alpha (MAP Kinase)抗体 | Anti-p38 alpha (MAP Kinase) antibody
掲載日情報：2018/10/03 現在Webページ番号：251724
StressMarq Biosciences社の抗p38 alpha (MAP Kinase)抗体(Anti-p38 alpha (MAP Kinase) antibody)です。
※本製品は研究用です。研究用以外には使用できません。
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価格
[在庫・価格 ：2025年04月26日 12時55分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
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Anti-p38, Monoclonal |
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[在庫・価格 ：2025年04月26日 12時55分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
Anti-p38, Monoclonal
文献数： 0
- 商品コード：SMC-152C
- メーカー：STQ
- 包装：25μg
- 本製品は取扱中止になりました
| 説明文 | クローン：9F12 Genbank No： 1432 Gene Accession No： NP_001306.1 Protein Accession No： Q16539 |
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| 別包装品 | 別包装品あり | ||||||
| 法規制等 | |||||||
| 保存条件 | 法規備考 | ||||||
| 抗原種 | Human | 免疫動物 | Mouse | ||||
| 交差性 | Human/Mouse/Rat | 適用 | Antibody Microarray,ELISA,IHC,IP,Western Blot | ||||
| 標識 | Unlabeled | 性状 | Protein A/G Affinity Purified | ||||
| 吸収処理 | クラス | IgG | |||||
| クロナリティ | Monoclonal | フォーマット | |||||
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| 製品記事 | 抗p38 alpha (MAP Kinase)モノクローナル抗体(Anti-p38 alpha (MAP Kinase)) p38 alpha (MAP Kinase) antibody (9F12:クローン名) | StressMarq Biosciences 抗p38 alpha (MAP Kinase)抗体 | Anti-p38 alpha (MAP Kinase) antibody |
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製品情報
 | Immunohistochemistry analysis using Mouse Anti-p38 MAPK Monoclonal Antibody, Clone 9F12 (SMC-152). Tissue: Retinal Injury Model. Species: Mouse. Primary Antibody: Mouse Anti-p38 MAPK Monoclonal Antibody (SMC-152) at 1:1000. Secondary Antibody: Alexa Fluor 594 Goat Anti-Mouse (red). Courtesy of: Dr. Rajashekhar Gangaraju, University of Indiana, Department of Opthamology, Eugene and Marilyn Glick Eye Institute. |
 | Immunohistochemistry analysis using Mouse Anti-p38 MAPK Monoclonal Antibody, Clone 9F12 (SMC-152). Tissue: colon carcinoma. Species: Human. Fixation: Formalin. Primary Antibody: Mouse Anti-p38 MAPK Monoclonal Antibody (SMC-152) at 1:10000 for 12 hours at 4°C. Secondary Antibody: Biotin Goat Anti-Mouse at 1:2000 for 1 hour at RT. Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain at 200 µl for 2 minutes at RT. Magnification: 40x. |
 | Western Blot analysis of Human Cell lysates showing detection of p38 MAPK protein using Mouse Anti-p38 MAPK Monoclonal Antibody, Clone 9F12 (SMC-152). Load: 15 µg protein. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-p38 MAPK Monoclonal Antibody (SMC-152) at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. |
Product Name
p38 alpha (MAP Kinase) Antibody
Clonality
Monoclonal
Description
Mouse Anti-Human p38 alpha (MAP Kinase) Monoclonal IgG1
Research Areas
Cancer, Cell Signaling, Phosphorylation, Post-translational Modifications
Alternative Names
CSAID Binding protein 1 Antibody, CSBP1 Antibody, CSBP2 Antibody, EXIP Antibody, MAP kinase MXI2 Antibody, MAPkinase p38alpha Antibody, MAPK14 Antibody, p38 ALPHA Antibody, p38 MAP kinase Antibody, p38 mitogen activated protein kinase Antibody, RK Antibody, SAPK 2A Antibody, Stress activated protein kinase 2A Antibody
Clone Number
9F12
Host Species
Mouse
Isotype
IgG1
Immunogen
Full length recombinant protein expressed in E.coli cells
Applications
WB, IHC, IP, ELISA, AM
Species Reactivity
Human, Mouse, Rat
Accession Number
NP_001306.1
Gene ID
1432
Swiss Prot
Q16539
Specificity
Detects ~38kDa.
Purification
Protein G Purified
Storage Buffer
PBS, 50% glycerol, 0.09% sodium azide
Certificate of Analysis
Detects ~38kDa protein corresponding to p38α MAPK when loaded with 6 ng of purified p38α by chemiluminescent immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
References
Scientific Background
The MAPK (mitogen activated protein kinase) comprises a family of ubiquitous praline-directed, proteinserine/ threonine kinases which signal transduction pathways that control intracellular events including acute responses to hormones and major developmental changes in organisms (1). This super family consists of stress activated protein kinases (SAPKs); extracellular signal-regulated kinases (ERKs); and p38 kinases, each of which forms a separate pathway (2). The kinase members that populate each pathway are sequentially activated by phosphorylation. Upon activation, p38 MAPK/SAPK2α translocates into the nucleus where it phosphorylates one or more nuclear substrates, effecting transcriptional changes and other cellular processes involved in cell growth, division, differentiation, inflammation, and death (3). Specifically p38 always acts as a pro-apoptotic factor with its activation leading to the release of cytochrome c from mitochondria and cleavage of caspase 3 and its downstream effector, PARP (4). p38 MAPK is activated by a variety of chemical stress inducers including hydrogen peroxide, heavy metals, anisomycin, sodium salicylate, LPS, and biological stress signals such as tumor necrosis factor, interleukin-1, ionizing and UV irradiation, hyperosmotic stress and chemotherapeutic drugs (5). As a result, p38 alpha has been widely validated as a target for inflammatory disease including rheumatoid arthritis, COPD and psoriasis (6) and has also been implicated in cancer, CNS and diabetes (7).
References
1. Pearson, G. et al (2001). Endocrine Reviews 22 (2): 153-183.
2. Fan, Y. et al (2007) Mol. Cells 23 (1): 30-38.
3. Han, J. et al. (1994) Science 265: 808-811.
4. Van, L. A., et al. (2004) Faseb J. 18: 1946−1948.
5. Deng et al. (2003) Cell. 115: 61-70.
6. Salojin KV, et al. (2006) J Immunol. 176 (3):1899-907.
7. Medicherla S. et al. (2006). J Pharmacol Exp Ther.318(1): 99-107.
The MAPK (mitogen activated protein kinase) comprises a family of ubiquitous praline-directed, proteinserine/ threonine kinases which signal transduction pathways that control intracellular events including acute responses to hormones and major developmental changes in organisms (1). This super family consists of stress activated protein kinases (SAPKs); extracellular signal-regulated kinases (ERKs); and p38 kinases, each of which forms a separate pathway (2). The kinase members that populate each pathway are sequentially activated by phosphorylation. Upon activation, p38 MAPK/SAPK2α translocates into the nucleus where it phosphorylates one or more nuclear substrates, effecting transcriptional changes and other cellular processes involved in cell growth, division, differentiation, inflammation, and death (3). Specifically p38 always acts as a pro-apoptotic factor with its activation leading to the release of cytochrome c from mitochondria and cleavage of caspase 3 and its downstream effector, PARP (4). p38 MAPK is activated by a variety of chemical stress inducers including hydrogen peroxide, heavy metals, anisomycin, sodium salicylate, LPS, and biological stress signals such as tumor necrosis factor, interleukin-1, ionizing and UV irradiation, hyperosmotic stress and chemotherapeutic drugs (5). As a result, p38 alpha has been widely validated as a target for inflammatory disease including rheumatoid arthritis, COPD and psoriasis (6) and has also been implicated in cancer, CNS and diabetes (7).
References
1. Pearson, G. et al (2001). Endocrine Reviews 22 (2): 153-183.
2. Fan, Y. et al (2007) Mol. Cells 23 (1): 30-38.
3. Han, J. et al. (1994) Science 265: 808-811.
4. Van, L. A., et al. (2004) Faseb J. 18: 1946−1948.
5. Deng et al. (2003) Cell. 115: 61-70.
6. Salojin KV, et al. (2006) J Immunol. 176 (3):1899-907.
7. Medicherla S. et al. (2006). J Pharmacol Exp Ther.318(1): 99-107.
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