Rasfonin (CAS: 303156-68-5)

C₂₅H₃₈O₆

• Selective apoptosis inducer in ras-dependent cells.
• Autophagy (Akt-dependent), apoptosis and necroptosis inducer in renal cancer cell lines.
• Induces death of ras-mutated pancreatic tumor (Panc-1) cells in vitro and in vivo.
• Robust inhibitor of pancreatic cancers with the K-ras mutation. Reduced Sos1 expression and depressed Ras-MAPK activity.

1. Rasfonin, a New Apoptosis Inducer in ras-dependent Cells from Talaromyces sp.: T. Tomikawa, et al.; J. Antibiot. 53, 848 (2000)
2. Total synthesis of TT-1 (rasfonin), an α-pyrone-containing natural product from a fungus Trichurus terrophilus: K. Akiyama, et al.; Tetrahedron 61, 1827 (2005)
3. Toward the Development of a General Chiral Auxiliary. Enantioselective Alkylation and a New Catalytic Asymmetric Addition of Silyloxyfurans: Application to a Total Synthesis of (-)-Rasfonin: R.K. Boeckman, et al.; JACS 128, 11032 (2006)
4. Rasfonin, a novel 2-pyrone derivative, induces ras-mutated Panc-1 pancreatic tumor cell death in nude mice: Z. Xiao, et al.; Cell Death Dis. 22, e1241 (2014)
5. Akt inhibition attenuates rasfonin-induced autophagy and apoptosis through the glycolytic pathway in renal cancer cells: Q. Lu, et al.; Cell Death Dis. 6, e2005 (2015)
6. Rasfonin promotes autophagy and apoptosis via upregulation of reactive oxygen species (ROS)/JNK pathway: W. Wang, et al.; Mycology 7, 64 (2016)
7. Fungal secondary metabolites rasfonin induces autophagy, apoptosis and necroptosis in renal cancer cell line: H. Sun, et al.; Mycology 7, 81 (2016)