S-5751 | CAS:209268-36-0

• 価格
• 構造式
• 製品情報
• 製品詳細
• 文献

価格

目次に戻る

構造式

目次に戻る

製品情報

S-5751 is an antagonist of the prostaglandin D₂ (PGD₂) receptor DP₁ (K_i = 1.6 nM) that shows at least 20-fold selectivity over receptors for thromboxane and prostacyclin, as well as the PGE₂ receptor EP₂. Orally administered S-5751 blocks PGD₂-induced plasma exudation in the conjunctiva (ED₅₀ = 0.099 mg/kg) and suppresses antigen-induced allergic responses in guinea pigs. S-5751 has been used to distinguish signaling of PGD₂ through its two receptors, DP₁ and DP₂ (also known as CRTH2).

目次に戻る

製品詳細

name	S-5751
Formal Name	(5Z)-7-[(1R,2R,3S,5S)-2-[[(5-hydroxybenzo[b]thien-3-yl)carbonyl]amino]-6,6-dimethylbicyclo[3.1.1]hept-3-yl]-5-heptenoic acid
CAS Number	209268-36-0
Molecular Formula	C25H31NO4S
Formula Weight	441.6
Purity	≥95%
Formulation	A crystalline solid
λmax	221, 269, 317 nm
SMILES	OC(CCC/C=C\C[C@H]1C[C@@H]2C(C)(C)[C@@H](C2)[C@@H]1NC(C3=CSC4=C3C=C(O)C=C4)=O)=O
InChI Code	InChI=1S/C25H31NO4S/c1-25(2)16-11-15(7-5-3-4-6-8-22(28)29)23(20(25)12-16)26-24(30)19-14-31-21-10-9-17(27)13-18(19)21/h3,5,9-10,13-16,20,23,27H,4,6-8,11-12H2,1-2H3,(H,26,30)(H,28,29)/b5-3-/t15-,16-,20-,23+/m0/s1
InChI Key	ZXBHFWFKSIYJEK-MFJOXFORSA-N
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
Stability	≥ 2 years

目次に戻る

文献

1. Arimura, A., Yasui, K., Kishino, J., et al. Prevention of allergic inflammation by a novel prostaglandin receptor antagonist, S-5751. Journal of Pharmacology and Experimental Therapeutics 298(2), 411-419 (2001).

2. Tsuri, T., Honma, T., Hiramatsu, Y., et al. Bicyclo[2.2.1]heptane and 6,6-dimethylbicyclo[3.1.1]heptane derivatives: Orally active, potent, and selective prostaglandin D2 receptor antagonists. J. Med. Chem. 40(22), 3504-3507 (1997).

3. Choi, Y.H., Lee, S.-N., Aoyahi, H., et al. The extracellular signal-regulated kinase mitogen-activated protein kinase/ribosomal S6 protein kinase 1 cascade phosphorylates cAMP response element-binding protein to induce MUC5B gene expression via D-prostanoid receptor signaling. J. Biol. Chem. 286(39), 34199-33214 (2011).

目次に戻る