抗Anti-Human VISTA/B7-H5/PD-1H MAb (Clone 730835)抗体(Anti-Human VISTA/B7-H5/PD-1H MAb (Clone 730835 antibody)
掲載日情報：2019/10/21 現在Webページ番号：232723
Anti-Human VISTA/B7-H5/PD-1H MAb (Clone 730835)に対する抗体(Anti-Human VISTA/B7-H5/PD-1H MAb (Clone 730835 )です。
※ 本製品は研究用です。研究用以外には使用できません。
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価格
[在庫・価格 ：2024年05月03日 19時35分現在]
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Anti-Human VISTA/B7-H5/PD-1H MAb (Clone 730835) |
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Anti-Human VISTA/B7-H5/PD-1H MAb (Clone 730835) |
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[在庫・価格 ：2024年05月03日 19時35分現在]
Anti-Human VISTA/B7-H5/PD-1H MAb (Clone 730835)
文献数： 0
- 商品コード：MAB71264-SP
- メーカー：RSD
- 包装：25μg
- 価格：¥30,000
- 在庫：無(未発注)
- 納期：2～3週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
Anti-Human VISTA/B7-H5/PD-1H MAb (Clone 730835)
文献数： 0
- 商品コード：MAB71264-100
- メーカー：RSD
- 包装：100μg
- 価格：¥86,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
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Product Details
| Species Reactivity | Human |
|---|---|
| Label | Unconjugated |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant human VISTA/B7-H5/PD-1HMet1-Ala194Accession # Q9H7M9 |
| Source | Monoclonal Mouse IgG2A Clone # 730835 |
| Purification | Protein A or G purified from hybridoma culture supernatant |
| Specificity | Detects human VISTA/B7-H5/PD-1H in direct ELISAs. |
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Applications and Data
| Recommended Concentration | Sample | |
| ELISA | This antibody functions as an ELISA capture antibody when paired with Sheep Anti-Human VISTA/B7-H5/PD-1H Antigen Affinity-purified Polyclonal Antibody (Catalog # AF7126). This product is intended for assay development on various assay platforms requiring antibody pairs. We recommend the Human VISTA/B7-H5/PD-1H DuoSet ELISA Kit (Catalog # DY7126-05) for convenient development of a sandwich ELISA. | |
| ELISA | |
|---|---|
 | Human VISTA/B7-H5/PD-1H ELISA Standard Curve. Recombinant Human VISTA/B7-H5/PD-1H protein was serially diluted 2-fold and captured by Mouse Anti-Human VISTA/B7-H5/PD-1H Monoclonal Antibody (Catalog # MAB71264) coated on a Clear Polystyrene Microplate (Catalog # DY990). Sheep Anti-Human VISTA/B7-H5/PD-1H Antigen Affinity-purified Polyclonal Antibody (Catalog # AF7126) was biotinylated and incubated with the protein captured on the plate. Detection of the standard curve was achieved by incubating Streptavidin-HRP (Catalog # DY998) followed by Substrate Solution (Catalog # DY999) and stopping the enzymatic reaction with Stop Solution (Catalog # DY994). |
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Related Product & Information
| Entrez Gene IDs | 64115 (Human); 74048 (Mouse); 690899 (Rat); 102116468 (Cynomolgus Monkey) |
|---|---|
| Background | VISTA/B7-H5/PD-1H |
| background_content | Background: VISTA/B7-H5/PD-1H Platelet Receptor Gi24, also known as Dies1 (Differentiation of ESC-1), VISTA (V-domain Ig suppressor of T cell activation), B7-H5, SISP1, and C10orf54, is a 55-65 kDa member of the Ig superfamily. It is a transmembrane molecule expressed in bone, on embryonic stem cells (ESCs), and on tumor cell surfaces. On ESCs, Gi24 appears to positively interact with BMP-4, potentiating BMP signaling and the transition from an undifferentiated to a differentiated state. On tumor cells, Gi24 both promotes MT1-MMP expression and activity and serves as a substrate for MT1-MMP. This increases the potential for cell motility. Mature human Gi24 contains a 162 aa extracellular region with one V-type Ig-like domain and a 96 aa cytoplasmic domain. Human Gi24 undergoes proteolytic cleavage by MT1-MMP, generating a soluble 30 kDa extracellular fragment plus a 25-30 kDa membrane-bound fragment. Over aa 33-194, human Gi24 shares 70% and 67% aa identity with mouse and rat Gi24, respectively. |
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