抗Anti-Human Wnt-5a MAb (Clone 871117R)抗体(Anti-Human Wnt-5a MAb (Clone 871117R antibody)
掲載日情報：2019/10/21 現在Webページ番号：232714
Anti-Human Wnt-5a MAb (Clone 871117R)に対する抗体(Anti-Human Wnt-5a MAb (Clone 871117R )です。
※ 本製品は研究用です。研究用以外には使用できません。
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価格
[在庫・価格 ：2024年05月08日 14時55分現在]
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Anti-Human Wnt-5a MAb (Clone 871117R) |
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Anti-Human Wnt-5a MAb (Clone 871117R) |
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[在庫・価格 ：2024年05月08日 14時55分現在]
Anti-Human Wnt-5a MAb (Clone 871117R)
文献数： 0
- 商品コード：MAB6452-100
- メーカー：RSD
- 包装：100μg
- 価格：¥103,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | Protein Accession No： P41221 | ||
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| 法規制等 | |||
| 保存条件 | 法規備考 | ||
| 抗原種 | 免疫動物 | Mouse | |
| 交差性 | Human | 適用 | ELISA |
| 標識 | Unlabeled | 性状 | Protein A/G Affinity Purified |
| 吸収処理 | クラス | ||
| クロナリティ | Recombinant | フォーマット | |
| 掲載カタログ |
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Anti-Human Wnt-5a MAb (Clone 871117R)
文献数： 0
- 商品コード：MAB6452-SP
- メーカー：RSD
- 包装：25μg
- 価格：¥30,000
- 在庫：無(未発注)
- 納期：2～3週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 |
※受注発注品。 Protein Accession No： P41221 |
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| 法規制等 | |||
| 保存条件 | 法規備考 | ||
| 抗原種 | 免疫動物 | Mouse | |
| 交差性 | Human | 適用 | ELISA |
| 標識 | Unlabeled | 性状 | Protein A/G Affinity Purified |
| 吸収処理 | クラス | ||
| クロナリティ | Recombinant | フォーマット | |
| 掲載カタログ |
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| 製品記事 | |||
| 関連記事 | |||
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Product Details
| Species Reactivity | Human |
|---|---|
| Label | Unconjugated |
| Immunogen | Chinese hamster ovary cell line CHO-derived recombinant human Wnt-5aGln38-Lys380Accession # P41221 |
| Source | Recombinant Monoclonal Mouse IgG1 Clone # 871117R |
| Purification | Protein A or G purified from cell culture supernatant |
| Specificity | Detects human Wnt-5a in direct ELISAs. |
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Applications and Data
| Recommended Concentration | Sample | |
| ELISA | This antibody functions as an ELISA capture antibody when paired with Mouse Anti-Human Wnt‑5a Monoclonal Antibody (Catalog # MAB6451). This product is intended for assay development on various assay platforms requiring antibody pairs. | |
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Related Product & Information
| Background | Wnt-5a |
|---|---|
| background_content | Background: Wnt-5a Wnt-5a is a 44-50 kDa member of the Wnt family of proteins (1-6). Based on its activity towards C57Mg mammary epithelium, it is classified as a nontransforming Wnt. Human Wnt‑5a is synthesized as a 380 amino acid (aa) precursor that contains a 37 aa signal sequence, a 25 aa prosegment, and a 319 aa mature region (1, 2, 3). The mature region has 24 cysteine residues that form multiple intrachain disulfide bonds, plus four N‑linked glycosylation sites that are utilized for proper secretion (3, 5, 7). There is also a palmitate adduct at Cys104 that is essential for activity, and a potential palmitoleic acid modification at Ser244 that may also contribute to secretion (7-9). One alternative start site is reported at Met16. Over aa 38-380, human and mouse Wnt‑5a are identical in amino acid sequence (1, 10). Cells known to express Wnt‑5a include brainstem astrocytes (11), mammary epithelium (12), CD34+ primitive progenitor stem cells (13), chondrocytes (14), CD34- pericytes and vascular smooth muscle cells (15), plus mesenchymal cells at various sites (16, 17). There are multiple receptors for Wnt‑5a. These include Fzd‑1, ‑2, ‑3, -4, -5, and -7 (3, 18-22), Ror2 (3), LRP6 (23), Ryk (24) and sFRP1 (25). All these molecules function within the context of a larger number of "co‑factors" that regulate signaling by the Wnts. Initially, it was suggested that there were three pathways for Wnt signaling; a beta -catenin-mediated canonical pathway, and two noncanonical pathways described as the Wnt/JNK (PCP) pathway and the Wnt/Ca++ pathway (26, 27). And it was assumed that various Wnts could be accommodated by these classifications. At present, it is now recognized that individual Wnts, through various combinations of receptor complex subunits, can have diverse effects, perhaps even within the same cell (3, 6, 27). Further complexity is introduced by the fact that Xenopus Wnt‑5a and Wnt‑11 are known to form bioactive heterodimers following Tyr sulfation (28). Thus, predicting the activity of Wnt‑5a, or any other Wnt, on any cell type will require substantial insight into the interaction between all the extracellular, cell surface and intracellular components of the Wnt signaling system. |
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