抗Anti-Mouse TNF RII/TNFRSF1B MAb (Clone 91026R)抗体(Anti-Mouse TNF RII/TNFRSF1B MAb (Clone 91026R antibody)
掲載日情報：2019/10/21 現在Webページ番号：232685
Anti-Mouse TNF RII/TNFRSF1B MAb (Clone 91026R)に対する抗体(Anti-Mouse TNF RII/TNFRSF1B MAb (Clone 91026R )です。
※ 本製品は研究用です。研究用以外には使用できません。
追加しました。
価格
[在庫・価格 ：2026年04月06日 18時15分現在]
| 詳細 | 商品名 |
|
文献数 | ||
|---|---|---|---|---|---|
|
Anti-Mouse TNF RII/TNFRSF1B MAb (Clone 91026R) |
|
0 | |||
|
Anti-Mouse TNF RII/TNFRSF1B MAb (Clone 91026R) |
|
0 | |||
[在庫・価格 ：2026年04月06日 18時15分現在]
Anti-Mouse TNF RII/TNFRSF1B MAb (Clone 91026R)
文献数： 0
- 商品コード：MAB4263-100
- メーカー：RSD
- 包装：100μg
- 価格：¥78,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
Anti-Mouse TNF RII/TNFRSF1B MAb (Clone 91026R)
文献数： 0
- 商品コード：MAB4263-SP
- メーカー：RSD
- 包装：25μg
- 価格：¥30,000
- 在庫：無(未発注)
- 納期：2～3週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
追加しました。
Product Details
| Species Reactivity | Mouse |
|---|---|
| Label | Unconjugated |
| Immunogen | E. coli-derived recombinant mouse TNF RII/TNFRSF1BVal23-Gly258Accession # Q545P4 |
| Source | Recombinant Monoclonal Rat IgG1 Clone # 91026R |
| Purification | Protein A or G purified from cell culture supernatant |
| Specificity | Detects mouse TNF RII/TNFRSF1B in direct ELISAs. |
追加しました。
Applications and Data
| Recommended Concentration | Sample | |
| ELISA | This antibody functions as an ELISA capture antibody when paired with Goat Anti-Mouse TNF RII/TNFRSF1B Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-426-PB). This product is intended for assay development on various assay platforms requiring antibody pairs. We recommend the Mouse sTNF RII/TNFRSF1B DuoSet ELISA Kit (Catalog # DY426) for convenient development of a sandwich ELISA or the Mouse/Rat TNF RII/TNFRSF1B Quantikine ELISA Kit (Catalog # MRT20) for a complete optimized ELISA. | |
追加しました。
Related Product & Information
| Background | TNF RII/TNFRSF1B |
|---|---|
| background_content | Background: TNF RII/TNFRSF1B Tumor Necrosis Factor Receptor II (TNF RII), also known as TNFRSF1B, p75/p80, and CD120b, is a type I transmembrane protein that belongs to the TNF receptor superfamily. It has a molecular weight of approximately 75 kDa (1-4). The TNF receptor superfamily is comprised of structurally related receptors that bind to TNF-related ligands and regulate numerous processes such as immune cell activation and apoptosis. Receptors in this superfamily are characterized by the presence of a cysteine-rich region in their extracellular domain (ECD) (1-3, 5). Mouse TNF RII contains four cysteine-rich repeats in its ECD, which shares 58% and 84% amino acid sequence identity with the human and rat orthologs, respectively. Several receptors in the TNF superfamily also contain intracellular death domains (DDs) that recruit caspase-interacting proteins to initiate apoptosis upon ligand binding. Those receptors that lack DDs, like TNF RII, bind TNF Receptor-associated Factors, which transduce signals generated by activation of these receptors (6, 7). TNF RII is expressed predominantly on cells of the hematopoietic lineage, such as T and natural killer cells, as well as on endothelial cells, microglia, astrocytes, neurons, oligodendrocytes, cardiac myocytes, and thymocytes (6, 8, 9). In humans, TNF RII is also located on mesenchymal stem cells (6, 9, 10). TNF RII binds to the membrane-bound forms of TNF-alpha and Lymphotoxin-alpha /TNF-beta ; soluble TNF is thought to signal predominately through TNF RI (7, 11). TNF RII activation primarily initiates pro-inflammatory and pro-survival responses via NF kappa B-dependent signaling pathways (6, 7, 12-15). However, under certain conditions, TNF RII signaling can induce apoptosis (6). TNF RII also exists as a soluble receptor, which can be generated by proteolytic cleavage of its ECD from the cell surface or by alternative splicing (2, 16). Soluble TNF RII is believed to inhibit TNF biological activity by binding TNF thereby preventing it from activating membrane TNF receptors (17). Polymorphisms of the human TNFR2 gene, which result in increased expression of both membrane-bound and soluble TNF RII, have been associated with several autoimmune diseases including Crohn’s disease, systemic lupus erythematosus, and familial rheumatoid arthritis (6, 17). |
追加しました。
製品情報は掲載時点のものですが、価格表内の価格については随時最新のものに更新されます。お問い合わせいただくタイミングにより製品情報・価格などは変更されている場合があります。
表示価格に、消費税等は含まれていません。一部価格が予告なく変更される場合がありますので、あらかじめご了承下さい。