抗Anti-Human TIM-1/KIM-1/HAVCR MAb (Clone 526114R)抗体(Anti-Human TIM-1/KIM-1/HAVCR MAb (Clone 526114R antibody)
掲載日情報：2019/10/21 現在Webページ番号：232598
Anti-Human TIM-1/KIM-1/HAVCR MAb (Clone 526114R)に対する抗体(Anti-Human TIM-1/KIM-1/HAVCR MAb (Clone 526114R )です。
※ 本製品は研究用です。研究用以外には使用できません。
追加しました。
価格
[在庫・価格 ：2024年05月02日 20時55分現在]
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Anti-Human TIM-1/KIM-1/HAVCR MAb (Clone 526114R) |
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Anti-Human TIM-1/KIM-1/HAVCR MAb (Clone 526114R) |
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[在庫・価格 ：2024年05月02日 20時55分現在]
Anti-Human TIM-1/KIM-1/HAVCR MAb (Clone 526114R)
文献数： 0
- 商品コード：MAB17502-100
- メーカー：RSD
- 包装：100μg
- 価格：¥94,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | Protein Accession No： AAC39862 | ||
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| 保存条件 | 法規備考 | ||
| 抗原種 | 免疫動物 | Mouse | |
| 交差性 | Human | 適用 | ELISA |
| 標識 | Unlabeled | 性状 | Protein A/G Affinity Purified |
| 吸収処理 | クラス | ||
| クロナリティ | Recombinant | フォーマット | |
| 掲載カタログ |
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| 製品記事 | |||
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Anti-Human TIM-1/KIM-1/HAVCR MAb (Clone 526114R)
文献数： 0
- 商品コード：MAB17502-SP
- メーカー：RSD
- 包装：25μg
- 価格：¥30,000
- 在庫：無(未発注)
- 納期：2～3週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 |
※受注発注品。 Protein Accession No： AAC39862 |
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| 法規制等 | |||
| 保存条件 | 法規備考 | ||
| 抗原種 | 免疫動物 | Mouse | |
| 交差性 | Human | 適用 | ELISA |
| 標識 | Unlabeled | 性状 | Protein A/G Affinity Purified |
| 吸収処理 | クラス | ||
| クロナリティ | Recombinant | フォーマット | |
| 掲載カタログ |
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| 製品記事 | |||
| 関連記事 | |||
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Product Details
| Species Reactivity | Human |
|---|---|
| Label | Unconjugated |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant human TIM-1/KIM-1/HAVCRSer21-Thr288Accession # AAC39862 |
| Source | Recombinant Monoclonal Mouse IgG1 Clone # 526114R |
| Purification | Protein A or G purified from cell culture supernatant |
| Specificity | Detects human TIM-1/KIM-1/HAVCR in direct ELISAs. |
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Applications and Data
| Recommended Concentration | Sample | |
| ELISA | This antibody functions as an ELISA capture antibody when paired with Goat Anti-Human TIM‑1/KIM‑1/HAVCR Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1750). This product is intended for assay development on various assay platforms requiring antibody pairs. We recommend the Human TIM-1/KIM-1/HAVCR DuoSet ELISA Kit (Catalog # DY1750B) for convenient development of a sandwich ELISA. For a complete optimized ELISA, we offer the Human Serum TIM-1/KIM-1/HAVCR Quantikine ELISA Kit (Catalog # DSKM100)or the Human Urinary TIM-1/KIM-1/HAVCR Quantikine ELISA Kit (Catalog # DKM100). | |
| ELISA | |
|---|---|
 | Human TIM‑1/KIM‑1/HAVCR ELISA Standard Curve. Recombinant Human TIM‑1/KIM‑1/HAVCR protein was serially diluted 2-fold and captured by Mouse Anti-Human TIM‑1/KIM‑1/HAVCR Monoclonal Antibody (Catalog # MAB17502) coated on a Clear Polystyrene Microplate (Catalog # DY990). Goat Anti-Human TIM‑1/KIM‑1/HAVCR Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1750) was biotinylated and incubated with the protein captured on the plate. Detection of the standard curve was achieved by incubating Streptavidin-HRP (Catalog # DY998) followed by Substrate Solution (Catalog # DY999) and stopping the enzymatic reaction with Stop Solution (Catalog # DY994). |
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Related Product & Information
| Background | TIM-1/KIM-1/HAVCR |
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| background_content | Background: TIM-1/KIM-1/HAVCR TIM-1 (T cell-immunoglobulin-mucin; also KIM-1 and HAVcr-1) is a 100 kDa, type I transmembrane glycoprotein member of the TIM family of immunoglobulin superfamily molecules (1-3). This gene family is involved in the regulation of Th1 and Th2-cell-mediated immunity. Human TIM-1 is synthesized as a 359 amino acid (aa) precursor that contains a 20 aa signal sequence, a 270 aa extracellular domain (ECD), a 21 aa transmembrane segment and a 48 aa cytoplasmic domain (4-6). The ECD contains one V-type Ig-like domain and a mucin region characterized by multiple PTTTTL motifs. The mucin region undergoes extensive O-linked glycosylation. The TIM-1 gene is highly polymorphic and undergoes alternate splicing (1). For instance, the presence of a six aa sequence (MTTTVP) at position # 137 of the mature molecule is associated with protection from atopy in people with a history of hepatitis A (7, 8). There are two cytoplasmic alternate splice forms of TIM-1. One is a long (359 aa) kidney form termed TIM-1b, and one is a short (334 aa) liver form termed TIM-1a. Both are identical through the first 323 aa of their precursors. TIM-1b contains a tyrosine phosphorylation motif that is not present in 1a (6). TIM-1 is also known to circulate as a soluble form. Constitutive cleavage by an undefined MMP (possibly ADAM33) releases an 85-90 kDa soluble molecule (6). The ECD of human TIM-1 is 50% and 43% aa identical to mouse and canine TIM-1 ECD, respectively. The only two reported ligands for TIM-1 are TIM-4 and the hepatitis A virus (4, 9). However, others are believed to exist, and based on the ligand for TIM-3, one may well be an S-type lectin (10). TIM-1 ligation induces T cell proliferation and promotes cytokine production (1, 10). |
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