抗Anti-Human IL-17F MAb (Clone 775608R)抗体(Anti-Human IL-17F MAb (Clone 775608R antibody)
掲載日情報：2019/10/21 現在Webページ番号：232571
Anti-Human IL-17F MAb (Clone 775608R)に対する抗体(Anti-Human IL-17F MAb (Clone 775608R )です。
※ 本製品は研究用です。研究用以外には使用できません。
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価格
[在庫・価格 ：2024年06月01日 20時55分現在]
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Anti-Human IL-17F MAb (Clone 775608R) |
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Anti-Human IL-17F MAb (Clone 775608R) |
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[在庫・価格 ：2024年06月01日 20時55分現在]
Anti-Human IL-17F MAb (Clone 775608R)
文献数： 0
- 商品コード：MAB13354-100
- メーカー：RSD
- 包装：100μg
- 価格：¥100,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
Anti-Human IL-17F MAb (Clone 775608R)
文献数： 0
- 商品コード：MAB13354-SP
- メーカー：RSD
- 包装：25μg
- 価格：¥30,000
- 在庫：無(未発注)
- 納期：2～3週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
追加しました。
Product Details
| Species Reactivity | Human |
|---|---|
| Label | Unconjugated |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant human IL-17FGly21-Thr153Accession # Q96PD4 |
| Source | Recombinant Monoclonal Mouse IgG2B Clone # 775608R |
| Purification | Protein A or G purified from cell culture supernatant |
| Specificity | Detects human IL-17F in direct ELISAs. |
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Applications and Data
| Recommended Concentration | Sample | |
| ELISA | This antibody functions as an ELISA capture antibody when paired with Mouse Anti-Human IL‑17F Monoclonal Antibody (Catalog # MAB13353). This product is intended for assay development on various assay platforms requiring antibody pairs. We recommend the Human IL-17F DuoSet ELISA Kit (Catalog # DY1335B-05) for convenient development of a sandwich ELISA. | |
| ELISA | |
|---|---|
 | Human IL‑17F ELISA Standard Curve. Recombinant Human IL‑17F protein was serially diluted 2-fold and captured by Mouse Anti-Human IL‑17F Monoclonal Antibody (Catalog # MAB13354) coated on a Clear Polystyrene Microplate (Catalog # DY990). Mouse Anti-Human IL‑17F Monoclonal Antibody (Catalog # MAB13353) was biotinylated and incubated with the protein captured on the plate. Detection of the standard curve was achieved by incubating Streptavidin-HRP (Catalog # DY998) followed by Substrate Solution (Catalog # DY999) and stopping the enzymatic reaction with Stop Solution (Catalog # DY994). |
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Related Product & Information
| Background | IL-17F |
|---|---|
| background_content | Background: IL-17F The Interleukin 17 (IL-17) family proteins, comprising six members (IL‑17A through IL‑17F), are secreted, structurally related proteins that share a conserved cystine‑knot fold near the C-terminus, but have considerable sequence divergence at the N‑terminus. With the exception of IL‑17B, which exists as a non-covalently linked dimer, all IL‑17 family members are disulfide-linked dimers. IL‑17 family proteins are pro-inflammatory cytokines that induce local cytokine production and are involved in the regulation of immune functions (1, 2). Human IL‑17F cDNA encodes a 163 amino acid (a) protein with a putative 30 aa signal peptide. Among IL‑17 family members, IL‑17F is most closely related to IL‑17A (approximately 44% aa sequence homology), but shares only limited sequence homology (16‑30%) with IL-17B, C, D and E. Human and mouse IL-17F share 55% sequence identity. IL-17F is expressed in activated CD4+ T-cells and activated monocytes. Five receptors (IL-17 RA, B, C, D and E) have been identified (5). Although the ligands for IL-17 RD and E are not known yet, it is reported that IL-17 RA binds IL-17A, and IL‑17 RB binds IL‑17B and IL-17E. IL‑17 RC binds IL‑17A and IL‑17F with similarly high affinity and functions as a receptor for both IL‑17A and IL‑17F (5, 6). The biological activities mediated by IL‑17F are similar to those ofIL‑17. IL‑17F stimulates production of IL‑6, IL-8, G-CSF, and regulates cartilage matrix turnover by increasing matrix release and inhibiting new matrix synthesis (4).IL‑17F also inhibits angiogenesis and induces production of IL‑2, TGF-beta, and monocyte chemoattractant protein‑1 in endothelial cells (3). |
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