抗Lymphotoxin alpha [MLTA3698A (Pateclizumab)]組換え抗体 | Anti-Lymphotoxin alpha [MLTA3698A (Pateclizumab)] recombinant antibody
掲載日情報:2019/10/24 現在Webページ番号:218824
Absolute Antibody社の抗Lymphotoxin alpha [MLTA3698A (Pateclizumab)]組換え抗体(リコンビナント抗体)( Anti-Lymphotoxin alpha [MLTA3698A (Pateclizumab)] recombinant antibody)です。
※本製品は研究用です。研究用以外には使用できません。
追加しました。
価格
[在庫・価格 :2026年04月06日 20時55分現在]
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Anti-Lymphotoxin alpha, Rabbit IgG, Recombinant Monoclonal Antibody, clone MLTA3698A (Pateclizumab) |
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Anti-Lymphotoxin alpha, Rabbit IgG, Recombinant Monoclonal Antibody, clone MLTA3698A (Pateclizumab) |
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[在庫・価格 :2026年04月06日 20時55分現在]
Anti-Lymphotoxin alpha, Rabbit IgG, Recombinant Monoclonal Antibody, clone MLTA3698A (Pateclizumab)
文献数: 0
- 商品コード:Ab00773-23.0
- メーカー:ABA
- 包装:0.2mg
- 価格:¥143,000
- 在庫:無(未発注)
- 納期:2~3週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
| 説明文 | 組換え体抗体。Azide Free。※カスタム対応可能:CONJUmab (Carrier Free, Concentrated, High Purity & Low Endotoxin) 抗体や標識抗体(Biotin修飾や蛍光標識など)の見積をご希望の場合は、弊社までお問い合わせください。バッファー組成:PBS with 0.02% Proclin 300. 別名:LT,LT-alpha,TNF-beta,Tumor necrosis factor ligand superfamily member 1 クローン:MLTA3698A |
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| 保存条件 | 法規備考 | ||
| 抗原種 | 免疫動物 | Rabbit | |
| 交差性 | Human | 適用 | Blocking,Depletion,FCM,SPR |
| 標識 | Unlabeled | 性状 | Protein A/G Affinity Purified |
| 吸収処理 | クラス | IgG | |
| クロナリティ | Recombinant | フォーマット | |
| 掲載カタログ |
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Anti-Lymphotoxin alpha, Rabbit IgG, Recombinant Monoclonal Antibody, clone MLTA3698A (Pateclizumab)
文献数: 0
- 商品コード:Ab00773-23.0-BT
- メーカー:ABA
- 包装:1mg
- 価格:ご照会ください
- 在庫:無(未発注)
- 納期:2~3週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
| 説明文 | 組換え体抗体。Azide Free。※カスタム対応可能:CONJUmab (Carrier Free, Concentrated, High Purity & Low Endotoxin) 抗体や標識抗体(Biotin修飾や蛍光標識など)の見積をご希望の場合は、弊社までお問い合わせください。バッファー組成:PBS only. 別名:LT,LT-alpha,TNF-beta,Tumor necrosis factor ligand superfamily member 1 クローン:MLTA3698A |
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| 法規制等 | |||
| 保存条件 | 法規備考 | ||
| 抗原種 | 免疫動物 | Rabbit | |
| 交差性 | Human | 適用 | Blocking,Depletion,FCM,SPR |
| 標識 | Unlabeled | 性状 | Protein A/G Affinity Purified |
| 吸収処理 | クラス | IgG | |
| クロナリティ | Recombinant | フォーマット | |
| 掲載カタログ |
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| 製品記事 | |||
| 関連記事 | |||
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製品情報
| Description | Recombinant monoclonal antibody to Lymphotoxin alpha. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma MLTA3698A (Pateclizumab). This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
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| Species and Isotype | Rabbit IgG, kappa |
| Clone Number | MLTA3698A (Pateclizumab) |
| UniProt Accession Number of Target Protein | |
| Published Application(s) | FC; SPR; block; deplete |
| Published Species Reactivity | Human |
| Immunogen | This humanized antibody was derived from a mouse anti-human LT-a hybridoma mAb. |
| Specificity | This antibody is specific for lymphotoxin-alpha, and is able to bind both the soluble LTα3 homotrimeric form and the cell-surface LTα1β2 heterotrimer, which is transiently expressed on activated B and T cells (Th1, Th17). |
| Application Notes | This antibody has been shown to able to both block LTα-mediated signaling and selectively deplete LTα-expressing activated T and B cells, which has therapeutic applications in abrogating proinflammatory responses in rheumatoid arthritis (RA) pathology (Kennedy, 2014). Preliminary clinical trials demonstrated that administration of this antibody decreased serum levels of CXCL13, a biomarker of RA disease activity (Emu, 2012). In a phase II trial, this antibody had a trend for clinical effects on the symptoms of RA after 3 months of treatment, but the differences from placebo responses were not statistically significant (Kennedy, 2014). In a human peripheral blood mononuclear cell transplanted SCID mouse model of graft-versus-host disease, this antibody specifically depleted activated LTα-expressing human donor T and B cells, prolonging survival of the mice (Chiang, 2012). Finally, this antibody has been used to in FC and surface plasmon resonance analysis to characterise its interaction with the LTα ligand. |
| Antibody First Published in | Chiang et al. In Vivo Depletion of Lymphotoxin-Alpha Expressing Lymphocytes Inhibits Xenogeneic Graft-versus-Host-Disease PLoS ONE, 2012, Vol.7(3), p.e33106 PMID:22427961 |
| Note on publication | Describes the generation of this antibody and its use in prolonging survival in a mouse model of GVHD. |
| Purification | Protein A affinity purified |
| Supplied in | Standard size: PBS with 0.02% Proclin 300. Bulk size: PBS only. |
| Storage Recommendation | Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C |
| Concentration | See vial label. |
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