Chimera, Human, Recombinant 組換え体(リコンビナント)タンパク質 | Jagged 1/Fc Chimera, Human, Recombinant
掲載日情報：2018/02/08 現在Webページ番号：216304
R&D Systems社製の高品質なChimera, Human, Recombinantの組換え体タンパク質(Jagged 1/Fc Chimera, Human, Recombinant)です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 ：2025年06月22日 00時00分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
| 詳細 | 商品名 |
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文献数 | ||
|---|---|---|---|---|---|
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Jagged 1/Fc Chimera, Human, Recombinant, Carrier-free |
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14 | |||
[在庫・価格 ：2025年06月22日 00時00分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
Jagged 1/Fc Chimera, Human, Recombinant, Carrier-free
文献数： 14
- 商品コード：1277-JG-050
- メーカー：RSD
- 包装：50μg
- 価格：¥90,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
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バルク注文に関して
※バルク包装品も承ります。お気軽にお問合せ下さい。
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CF(Carrier-Free)とは？
R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。
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Product Details
- Source
- Chinese Hamster Ovary cell line, CHO-derivedHuman Jagged 1 (Ser32-Ser1046)Accession # P78504IEGRMDHuman IgG1(Pro100-Lys330)N-terminusC-terminus
- Accession #
- P78504
- Purity
- >90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Predicted Molecular Mass
- 137 kDa
- SDS-PAGE
- 170-180 kDa, under reducing conditions
- Activity
- Measured by the ability of the immobilized protein to enhance BMP-2 induced alkaline phosphatase activity in C3H10T1/2 mouse embryonic fibroblast cells. Nobta, M. et al. (2005) J. Biol. Chem. 280:15842. The ED50 for this effect is 0.5-2.0 μg/mL.
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Related Product & Information
- Entrez Gene IDs
- 182 (Human); 29146 (Rat)
- Background
- Jagged 1
- Jagged 1 is a 180 kDa type I transmembrane glycoprotein and member of the Delta-Serrate-Lag-2 (DSL) family of ligands that activate LIN12/Notch proteins. Human Jagged 1 is synthesized as a 1218 amino acid (aa) precursor that contains a 33 aa signal sequence, a 1034 aa extracellular domain (ECD), a 26 aa transmembrane segment, and a 125 aa cytoplasmic region (SwissProt # P78504). The ECD contains a DSL domain (aa 185-229), a cysteine-rich region, 15 EGF-like repeats, of which many bind calcium, and nine potential sites for N-linked glycosylation. Mature human Jagged 1 is 97% and 96% aa identical to mature mouse and rat Jagged 1, respectively. Jagged 1 is widely expressed in adult and fetal tissues. Jagged-Notch signaling specifies cell fate, regulates pattern formation, defines boundaries between different cell types, and modulates cell proliferation and differentiation, especially during hematopoiesis, myogenesis, neurogenesis, and development of vasculature (1-8). Mutations in human Jagged 1 are the cause of Alagille syndrome, an autosomal-dominant disorder characterized by intrahepatic cholestasis and abnormalities of heart, eye, vertebrae, as well as characteristic facial appearance (9-10).
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Citations
R&D Systems personnel manually curate a database that contains references using R&D Systems products.
The data collected includes not only links to publications in PubMed,
but also provides information about sample types, species, and experimental conditions.
The data collected includes not only links to publications in PubMed,
but also provides information about sample types, species, and experimental conditions.
Transdifferentiated Human Vascular Smooth Muscle Cells are a New Potential Cell Source for Endothelial Regeneration
Authors: X Hong, A Margariti, A Le Bras, L Jacquet, W Kong, Y Hu, Q Xu
Sci Rep, 2017;7(1):5590.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: X Hong, A Margariti, A Le Bras, L Jacquet, W Kong, Y Hu, Q Xu
Sci Rep, 2017;7(1):5590.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Identification and characterization of a novel Sso7d scaffold-based binder against Notch1
Authors: T Gocha, BM Rao, R DasGupta
Sci Rep, 2017;7(1):12021.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: T Gocha, BM Rao, R DasGupta
Sci Rep, 2017;7(1):12021.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Development of Functional Microfold (M) Cells from Intestinal Stem Cells in Primary Human Enteroids.
Authors: Rouch J, Scott A, Lei N, Solorzano-Vargas R, Wang J, Hanson E, Kobayashi M, Lewis M, Stelzner M, Dunn J, Eckmann L, Martin M
PLoS ONE, 2016;11(1):e0148216.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Rouch J, Scott A, Lei N, Solorzano-Vargas R, Wang J, Hanson E, Kobayashi M, Lewis M, Stelzner M, Dunn J, Eckmann L, Martin M
PLoS ONE, 2016;11(1):e0148216.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Jagged1 Instructs Macrophage Differentiation in Leprosy
PLoS Pathog, 2016;12(8):e1005808.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
PLoS Pathog, 2016;12(8):e1005808.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Notch1 signaling regulates the epithelial-mesenchymal transition and invasion of breast cancer in a Slug-dependent manner.
Authors: Shao, Shan, Zhao, Xiaoai, Zhang, Xiaojin, Luo, Minna, Zuo, Xiaoxiao, Huang, Shangke, Wang, Ying, Gu, Shanzhi, Zhao, Xinhan
Mol Cancer, 2015;14(1):28.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Shao, Shan, Zhao, Xiaoai, Zhang, Xiaojin, Luo, Minna, Zuo, Xiaoxiao, Huang, Shangke, Wang, Ying, Gu, Shanzhi, Zhao, Xinhan
Mol Cancer, 2015;14(1):28.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation.
Authors: Procopio M, Laszlo C, Al Labban D, Kim D, Bordignon P, Jo S, Goruppi S, Menietti E, Ostano P, Ala U, Provero P, Hoetzenecker W, Neel V, Kilarski W, Swartz M, Brisken C, Lefort K, Dotto G
Nat Cell Biol, 2015;17(9):1193-204.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Procopio M, Laszlo C, Al Labban D, Kim D, Bordignon P, Jo S, Goruppi S, Menietti E, Ostano P, Ala U, Provero P, Hoetzenecker W, Neel V, Kilarski W, Swartz M, Brisken C, Lefort K, Dotto G
Nat Cell Biol, 2015;17(9):1193-204.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Breast cancer cells promote a notch-dependent mesenchymal phenotype in endothelial cells participating to a pro-tumoral niche.
Authors: Ghiabi P, Jiang J, Pasquier J, Maleki M, Abu-Kaoud N, Halabi N, Guerrouahen B, Rafii S, Rafii A
J Transl Med, 2015;13(0):27.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Ghiabi P, Jiang J, Pasquier J, Maleki M, Abu-Kaoud N, Halabi N, Guerrouahen B, Rafii S, Rafii A
J Transl Med, 2015;13(0):27.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Augmented osteogenic responses in human aortic valve cells exposed to oxLDL and TLR4 agonist: a mechanistic role of Notch1 and NF-kappaB interaction.
Authors: Zeng Q, Song R, Ao L, Xu D, Venardos N, Fullerton D, Meng X
PLoS ONE, 2014;9(5):e95400.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Zeng Q, Song R, Ao L, Xu D, Venardos N, Fullerton D, Meng X
PLoS ONE, 2014;9(5):e95400.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Sphingosine-1-phosphate promotes expansion of cancer stem cells via S1PR3 by a ligand-independent Notch activation.
Authors: Hirata, Naoya, Yamada, Shigeru, Shoda, Takuji, Kurihara, Masaaki, Sekino, Yuko, Kanda, Yasunari
Nat Commun, 2014;5(0):4806.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Hirata, Naoya, Yamada, Shigeru, Shoda, Takuji, Kurihara, Masaaki, Sekino, Yuko, Kanda, Yasunari
Nat Commun, 2014;5(0):4806.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
3D niche microarrays for systems-level analyses of cell fate.
Authors: Ranga A, Gobaa S, Okawa Y, Mosiewicz K, Negro A, Lutolf M
Nat Commun, 2014;5(0):4324.
Species: N/A
Sample Type: Protein
Application: Bioassay
Authors: Ranga A, Gobaa S, Okawa Y, Mosiewicz K, Negro A, Lutolf M
Nat Commun, 2014;5(0):4324.
Species: N/A
Sample Type: Protein
Application: Bioassay
Notch1 stimulation induces a vascularization switch with pericyte-like cell differentiation of glioblastoma stem cells.
Authors: Guichet P, Guelfi S, Teigell M, Hoppe L, Bakalara N, Bauchet L, Duffau H, Lamszus K, Rothhut B, Hugnot J
Stem Cells, 2013;33(1):21-34.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Guichet P, Guelfi S, Teigell M, Hoppe L, Bakalara N, Bauchet L, Duffau H, Lamszus K, Rothhut B, Hugnot J
Stem Cells, 2013;33(1):21-34.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Notch signaling is involved in neurogenic commitment of human periodontal ligament-derived mesenchymal stem cells.
Authors: Osathanon T, Manokawinchoke J, Nowwarote N, Aguilar P, Palaga T, Pavasant P
Stem Cells Dev, 2013;22(8):1220-31.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Osathanon T, Manokawinchoke J, Nowwarote N, Aguilar P, Palaga T, Pavasant P
Stem Cells Dev, 2013;22(8):1220-31.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Angiotensin II Contributes to Renal Fibrosis Independently of Notch Pathway Activation.
Authors: Lavoz C, Rodrigues-Diez R, Benito-Martin A, Rayego-Mateos S, Rodrigues-Diez RR, Alique M, Ortiz A, Mezzano S, Egido J, Ruiz-Ortega M
PLoS ONE, 2012;7(7):e40490.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Authors: Lavoz C, Rodrigues-Diez R, Benito-Martin A, Rayego-Mateos S, Rodrigues-Diez RR, Alique M, Ortiz A, Mezzano S, Egido J, Ruiz-Ortega M
PLoS ONE, 2012;7(7):e40490.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Efficient differentiation of human embryonic and induced pluripotent stem cells into functional astrocytes.
Authors: Emdad L, D'Souza SL, Kothari HP, Qadeer ZA, Germano IM
Stem Cells Dev., 2012;21(3):404-10.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Emdad L, D'Souza SL, Kothari HP, Qadeer ZA, Germano IM
Stem Cells Dev., 2012;21(3):404-10.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
The alarmin IL-33 is a notch target in quiescent endothelial cells.
Authors: Sundlisaeter E, Edelmann R, Hol J, Sponheim J, Kuchler A, Weiss M, Udalova I, Midwood K, Kasprzycka M, Haraldsen G
Am J Pathol, 2012;181(3):1099-111.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Sundlisaeter E, Edelmann R, Hol J, Sponheim J, Kuchler A, Weiss M, Udalova I, Midwood K, Kasprzycka M, Haraldsen G
Am J Pathol, 2012;181(3):1099-111.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Blocking the NOTCH pathway inhibits vascular inflammation in large-vessel vasculitis.
Authors: Piggott K, Deng J, Warrington K, Younge B, Kubo JT, Desai M, Goronzy JJ, Weyand CM
Circulation, 2012;123(3):309-18.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Piggott K, Deng J, Warrington K, Younge B, Kubo JT, Desai M, Goronzy JJ, Weyand CM
Circulation, 2012;123(3):309-18.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
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