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Noggin Protein 組換え体(リコンビナント)タンパク質 | Recombinant Human Noggin Protein

掲載日情報：2018/02/07 現在Webページ番号：216020

アールアンドディー システムズ /
R&D Systems, Inc.
[メーカー略称：RSD]

R&D Systems社製の高品質なNoggin Proteinの組換え体タンパク質(Recombinant Human Noggin Protein)です。
※本製品は研究用です。研究用以外には使用できません。

[在庫・価格 ：2025年04月28日 16時55分現在]

※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
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Recombinant Human Noggin Protein
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説明文
純度：>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.，由来動物：Human，M.W.：23 kDa (monomer)，Genbank：9241，エンドトキシンレベル：<0.10 EU per 1 µg of the protein by the LAL method.，産生：NS0
別名：NOG
Genbank No： 9241
Protein Accession No： Q13253
法規制等
保存条件 -20℃ 法規備考
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製品記事
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Recombinant Human Noggin Protein, CF
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  • お問い合わせ
 10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。 0
  • メーカーサイト
  • お問い合わせ
説明文
純度：>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.，由来動物：Human，M.W.：23 kDa (monomer)，Genbank：9241，エンドトキシンレベル：<0.10 EU per 1 µg of the protein by the LAL method.，産生：NS0
別名：NOG
Genbank No： 9241
Protein Accession No： Q13253
法規制等
保存条件 -20℃ 法規備考
掲載カタログ

製品記事 肺オルガノイド培養関連製品（Products for Lung Organoids）
関連記事

[在庫・価格 ：2025年04月28日 16時55分現在]

※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。

Recombinant Human Noggin Protein

文献数： 0

説明文 純度：>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.，由来動物：Human，M.W.：23 kDa (monomer)，Genbank：9241，エンドトキシンレベル：<0.10 EU per 1 µg of the protein by the LAL method.，産生：NS0
別名：NOG
Genbank No： 9241
Protein Accession No： Q13253
法規制等
保存条件 -20℃ 法規備考
掲載カタログ

製品記事
関連記事
  • メーカーサイト
  • お問い合わせ

Recombinant Human Noggin Protein, CF

文献数： 0

説明文 純度：>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.，由来動物：Human，M.W.：23 kDa (monomer)，Genbank：9241，エンドトキシンレベル：<0.10 EU per 1 µg of the protein by the LAL method.，産生：NS0
別名：NOG
Genbank No： 9241
Protein Accession No： Q13253
法規制等
保存条件 -20℃ 法規備考
掲載カタログ

製品記事 肺オルガノイド培養関連製品（Products for Lung Organoids）
関連記事
  • メーカーサイト
  • お問い合わせ

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CF(Carrier-Free)とは？

R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。

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Product Details

Source
Mouse myeloma cell line, NS0-derivedGln28-Cys232
Accession #
Q13253
Purity
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Predicted Molecular Mass
23 kDa (monomer)
SDS-PAGE
30-33 kDa, reducing conditions
Activity
Measured by its ability to inhibit BMP-4-induced alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The ED50 for this effect is 0.04‑0.2 μg/mL in the presence of 50 ng/mL of Recombinant Human BMP‑4 (Catalog # 314-BP).

Bioactivity
BG01V human embryonic stem cells were cultured in Mouse Embryonic Fibroblast Conditioned Media supplemented with FGF basic (5 ng/mL). Stem cells were driven into early cells of the neuroectoderm using a 3 day incubation in recombinant human Noggin (25 µg/mL) from either R&D Systems (Lot 1, Lot 2; Catalog #6057-NG) or from two separate competitors (Competitor 1, Competitor 2). Control cells were not incubated in Noggin (No Noggin). The cells were stained for the early ectoderm marker, Otx2, and the neuroectoderm marker, SOX1. (A) Representative images of SOX1 (green), Otx2 (red), and DAPI (blue) staining in embryonic stem cells differentiated with Noggin from R&D Systems or Noggin from Competitor 2. (B) SOX1+ clusters were quantified under each of the indicated culture conditions. Cells treated with R&D Systems Noggin showed an increase in SOX1+ cells compared to both untreated and competitor-treated cells. R&D Systems Noggin showed consistent differentiation across the lots tested. BG01V human embryonic stem cells are licensed from ViaCyte, Inc.

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Related Product & Information

Entrez Gene IDs
9241 (Human); 18121 (Mouse)
Background
Noggin
Noggin is a secreted homodimeric glycoprotein that is an antagonist of bone morphogenetic proteins (BMPs) (1, 2). Human Noggin cDNA encodes a 232 amino acid (aa) precursor protein; cleavage of a 19 aa signal peptide generates the 213 aa mature protein which contains an N-terminal acidic region, a central basic heparin‑binding segment and a C-terminal cysteine-knot structure (2). Secreted Noggin probably remains close to the cell surface due to its binding of heparin‑containing proteoglycans (3). Noggin is very highly conserved among vertebrates, such that mature human Noggin shares 99%, 99%, 98%, 97% and 89% aa sequence identity with mouse, rat, bovine, equine and chicken Noggin, respectively. Noggin binds some BMPs such as BMP-4 with high affinity and others such as BMP-7 with lower affinity. It antagonizes BMP bioactivities by blocking epitopes on BMPs that are needed for binding to both type I and type II receptors (2, 4). During embryogenesis, Noggin antagonizes specific BMPs at defined times, for example, during neural tube, somite and cardiomyocyte growth and patterning (5-7). During skeletal development, Noggin prevents chondrocyte hyperplasia, thus allowing proper formation of joints (4). Mutations within the cysteine-knot region of human Noggin are linked to multiple types of skeletal dysplasias that result in apical joint fusions (8). Noggin is expressed in defined areas of the adult central nervous system and peripheral tissues such as lung, skeletal muscle and skin (1). During culture of human embryonic stem cells (hESC) or neural stem cells under certain conditions, addition of Noggin to antagonize BMP activity may allow stem cells to proliferate while maintaining their undifferentiated state, or alternatively, to differentiate into dopaminergic neurons (6, 9 - 13). Noggin also appears to maintain adult stem cell populations in-vivo, for example, maintaining neural stem cells within the hippocampus (13).

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Citations

R&D Systems personnel manually curate a database that contains references using R&D Systems products.
The data collected includes not only links to publications in PubMed,
but also provides information about sample types, species, and experimental conditions.
Differentiation of Human Pluripotent Stem Cells into Colonic Organoids via Transient Activation of BMP Signaling
Authors: JO Múnera, N Sundaram, SA Rankin, D Hill, C Watson, M Mahe, JE Vallance, NF Shroyer, KL Sinagoga, A Zarzoso-La, JR Hudson, JC Howell, P Chatuvedi, JR Spence, JM Shannon, AM Zorn, MA Helmrath, JM Wells
Cell Stem Cell, 2017;0(0):.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Differentiation of oligodendrocyte progenitor cells from dissociated monolayer and feeder-free cultured pluripotent stem cells
Authors: T Yamashita, Y Miyamoto, Y Bando, T Ono, S Kobayashi, A Doi, T Araki, Y Kato, T Shirakawa, Y Suzuki, J Yamauchi, S Yoshida, N Sato
PLoS ONE, 2017;12(2):e0171947.
Species: Primate
Sample Type: Whole Cells
Application: Bioassay
Bone morphogenetic protein signaling mediated by ALK-2 and DLX2 regulates apoptosis in glioma-initiating cells
Authors: E Raja, A Komuro, R Tanabe, S Sakai, Y Ino, N Saito, T Todo, M Morikawa, H Aburatani, D Koinuma, C Iwata, K Miyazono
Oncogene, 2017;0(0):.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors
Authors: KF Cogger, A Sinha, F Sarangi, EC McGaugh, D Saunders, C Dorrell, S Mejia-Guer, Y Aghazadeh, JL Rourke, RA Screaton, M Grompe, PR Streeter, AC Powers, M Brissova, T Kislinger, MC Nostro
Nat Commun, 2017;8(1):331.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
A pluripotent stem cell-based model for post-implantation human amniotic sac development
Authors: Y Shao, K Taniguchi, RF Townshend, T Miki, DL Gumucio, J Fu
Nat Commun, 2017;8(1):208.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
REST suppression mediates neural conversion of adult human fibroblasts via microRNA-dependent and -independent pathways
Authors: J Drouin-Oue, S Lau, PL Brattås, D Rylander O, K Pircs, DA Grassi, LM Collins, R Vuono, A Andersson, G Westergren, C Graff, L Minthon, H Toresson, RA Barker, J Jakobsson, M Parmar
EMBO Mol Med, 2017;9(8):1117-1131.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Zeb2 is a negative regulator of midbrain dopaminergic axon growth and target innervation
Authors: SV Hegarty, SL Wyatt, L Howard, E Stappers, D Huylebroec, AM Sullivan, GW O'Keeffe
Sci Rep, 2017;7(1):8568.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
A hypomorphic PIGA gene mutation causes severe defects in neuron development and susceptibility to complement-mediated toxicity in a human iPSC model
Authors: X Yuan, Z Li, AC Baines, E Gavriilaki, Z Ye, Z Wen, EM Braunstein, LG Biesecker, L Cheng, X Dong, RA Brodsky
PLoS ONE, 2017;12(4):e0174074.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Melanoma-Derived iPCCs Show Differential Tumorigenicity and Therapy Response
Authors: M Bernhardt, D Novak, Y Assenov, E Orouji, N Knappe, K Weina, M Reith, L Larribere, C Gebhardt, C Plass, V Umansky, J Utikal
Stem Cell Reports, 2017;0(0):.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Wnt/?-catenin promotes gastric fundus specification in mice and humans
Authors: KW McCracken, E Aihara, B Martin, CM Crawford, T Broda, J Treguier, X Zhang, JM Shannon, MH Montrose, JM Wells
Nature, 2017;0(0):.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Reductive carboxylation is a major metabolic pathway in the retinal pigment epithelium
Proc. Natl. Acad. Sci. U.S.A., 2016;0(0):.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Altered neuronal network and rescue in a human MECP2 duplication model
Mol. Psychiatry, 2016;21(2):178-88.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Remyelination Is Correlated with Regulatory T Cell Induction Following Human Embryoid Body-Derived Neural Precursor Cell Transplantation in a Viral Model of Multiple Sclerosis
Authors: Warren C Plaisted
PLoS ONE, 2016;11(6):e0157620.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Growth hormone is permissive for neoplastic colon growth
Proc Natl Acad Sci USA, 2016;0(0):.
Species: Human
Sample Type: Whole Tissue
Application: Bioassay
A dynamic Shh expression pattern, regulated by SHH and BMP signaling, coordinates fusion of primordia in the amniote face.
Authors: Hu D, Young N, Li X, Xu Y, Hallgrimsson B, Marcucio R
Development, 2015;142(3):567-74.
Species: Chicken
Sample Type: Whole Organism
Application: In Vivo
TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors.
Authors: Cebola I, Rodriguez-Segui S, Cho C, Bessa J, Rovira M, Luengo M, Chhatriwala M, Berry A, Ponsa-Cobas J, Maestro M, Jennings R, Pasquali L, Moran I, Castro N, Hanley N, Gomez-Skarmeta J, Vallier L, Ferrer J
Nat Cell Biol, 2015;17(5):615-26.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Persistence and toxin production by Clostridium difficile within human intestinal organoids result in disruption of epithelial paracellular barrier function.
Authors: Leslie J, Huang S, Opp J, Nagy M, Kobayashi M, Young V, Spence J
Infect Immun, 2015;83(1):138-45.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Resveratrol ameliorates the maturation process of beta-cell-like cells obtained from an optimized differentiation protocol of human embryonic stem cells.
Authors: Pezzolla D, Lopez-Beas J, Lachaud C, Dominguez-Rodriguez A, Smani T, Hmadcha A, Soria B
PLoS ONE, 2015;10(3):e0119904.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
In vitro generation of human pluripotent stem cell derived lung organoids.
Authors: Dye, Briana R, Hill, David R, Ferguson, Michael, Tsai, Yu-Hwai, Nagy, Melinda, Dyal, Rachel, Wells, James M, Mayhew, Christop, Nattiv, Roy, Klein, Ophir D, White, Eric S, Deutsch, Gail H, Spence, Jason R
Elife, 2015;4(0):.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Early intervention for spinal cord injury with human induced pluripotent stem cells oligodendrocyte progenitors.
Authors: All A, Gharibani P, Gupta S, Bazley F, Pashai N, Chou B, Shah S, Resar L, Cheng L, Gearhart J, Kerr C
PLoS ONE, 2015;10(1):e0116933.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
SMAD4 exerts a tumor-promoting role in hepatocellular carcinoma.
Authors: Hernanda P, Chen K, Das A, Sideras K, Wang W, Li J, Cao W, Bots S, Kodach L, de Man R, Ijzermans J, Janssen H, Stubbs A, Sprengers D, Bruno M, Metselaar H, ten Hagen T, Kwekkeboom J, Peppelenbosch M, Pan Q
Oncogene, 2015;34(39):5055-68.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells.
Authors: Huang S, Green M, de Carvalho A, Mumau M, Chen Y, D'Souza S, Snoeck H
Nat Protoc, 2015;10(3):413-25.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Endodermal differentiation of human pluripotent stem cells to insulin-producing cells in 3D culture.
Authors: Takeuchi, Hiroki, Nakatsuji, Norio, Suemori, Hirofumi
Sci Rep, 2014;4(0):4488.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Highly efficient generation of induced neurons from human fibroblasts that survive transplantation into the adult rat brain.
Authors: Pereira, Maria, Pfisterer, Ulrich, Rylander, Daniella, Torper, Olof, Lau, Shong, Lundblad, Martin, Grealish, Shane, Parmar, Malin
Sci Rep, 2014;4(0):6330.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Influence of in vitro and in vivo oxygen modulation on beta cell differentiation from human embryonic stem cells.
Authors: Cechin S, Alvarez-Cubela S, Giraldo J, Molano R, Villate S, Ricordi C, Pileggi A, Inverardi L, Fraker C, Dominguez-Bendala J
Stem Cells Transl Med, 2014;3(3):277-89.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
A synthetic peptide-acrylate surface for production of insulin-producing cells from human embryonic stem cells.
Authors: Lin P, Hung S, Yang Y, Liao L, Hsieh Y, Yen H, Lu H, Lee M, Chu I, Hwang S
Stem Cells Dev, 2014;23(4):372-9.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
CEP290 gene transfer rescues Leber congenital amaurosis cellular phenotype.
Authors: Burnight E, Wiley L, Drack A, Braun T, Anfinson K, Kaalberg E, Halder J, Affatigato L, Mullins R, Stone E, Tucker B
Gene Ther, 2014;21(7):662-72.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Retinoic acid signalling regulates the development of tonotopically patterned hair cells in the chicken cochlea.
Authors: Thiede B, Mann Z, Chang W, Ku Y, Son Y, Lovett M, Kelley M, Corwin J
Nat Commun, 2014;5(0):3840.
Species: Chicken
Sample Type: Whole Tissue
Application: Bioassay
Prospectively isolated NGN3-expressing progenitors from human embryonic stem cells give rise to pancreatic endocrine cells.
Authors: Cai, Qing, Bonfanti, Paola, Sambathkumar, Rangaraj, Vanuytsel, Kim, Vanhove, Jolien, Gysemans, Conny, Debiec-Rychter, Maria, Raitano, Susanna, Heimberg, Harry, Ordovas, Laura, Verfaillie, Catherin
Stem Cells Transl Med, 2014;3(4):489-99.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Bone morphogenetic protein 2 signaling negatively modulates lymphatic development in vertebrate embryos.
Authors: Dunworth, William, Cardona-Costa, Jose, Bozkulak, Esra Cag, Kim, Jun-Dae, Meadows, Stryder, Fischer, Johanna, Wang, Yeqi, Cleaver, Ondine, Qyang, Yibing, Ober, Elke A, Jin, Suk-Won
Circ Res, 2014;114(1):56-66.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Rapid and efficient differentiation of human pluripotent stem cells into intermediate mesoderm that forms tubules expressing kidney proximal tubular markers.
Authors: Lam A, Freedman B, Morizane R, Lerou P, Valerius M, Bonventre J
J Am Soc Nephrol, 2014;25(6):1211-25.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Selective lentiviral gene delivery to CD133-expressing human glioblastoma stem cells.
Authors: Bayin, N Sumru, Modrek, Aram S, Dietrich, August, Lebowitz, Jonathan, Abel, Tobias, Song, Hae-Ri, Schober, Markus, Zagzag, David, Buchholz, Christia, Chao, Moses V, Placantonakis, Dimitris
PLoS ONE, 2014;9(12):e116114.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Inner ear hair cell-like cells from human embryonic stem cells.
Authors: Ronaghi, Mohammad, Nasr, Marjan, Ealy, Megan, Durruthy-Durruthy, Robert, Waldhaus, Joerg, Diaz, Giovanni, Joubert, Lydia-Ma, Oshima, Kazuo, Heller, Stefan
Stem Cells Dev, 2014;23(11):1275-84.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Optimal effector functions in human natural killer cells rely upon autocrine bone morphogenetic protein signaling.
Authors: Robson N, Hidalgo L, McAlpine T, Wei H, Martinez V, Entrena A, Melen G, MacDonald A, Phythian-Adams A, Sacedon R, Maraskovsky E, Cebon J, Ramirez M, Vicente A, Varas A
Cancer Res, 2014;74(18):5019-31.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Polycomb group protein expression during differentiation of human embryonic stem cells into pancreatic lineage in vitro.
Authors: Pethe, Prasad, Nagvenkar, Punam, Bhartiya, Deepa
BMC Cell Biol, 2014;15(0):18.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Real-time discrimination between proliferation and neuronal and astroglial differentiation of human neural stem cells.
Authors: Lee, Rimi, Kim, Il-Sun, Han, Nalae, Yun, Seokhwan, Park, Kook In, Yoo, Kyung-Hw
Sci Rep, 2014;4(0):6319.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Dual small-molecule targeting of SMAD signaling stimulates human induced pluripotent stem cells toward neural lineages.
Authors: Wattanapanitch M, Klincumhom N, Potirat P, Amornpisutt R, Lorthongpanich C, U-pratya Y, Laowtammathron C, Kheolamai P, Poungvarin N, Issaragrisil S
PLoS ONE, 2014;9(9):e106952.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Primary cilia in stem cells and neural progenitors are regulated by neutral sphingomyelinase 2 and ceramide.
Authors: He Q, Wang G, Wakade S, Dasgupta S, Dinkins M, Kong J, Spassieva S, Bieberich E
Mol Biol Cell, 2014;25(11):1715-29.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
A gradient of Bmp7 specifies the tonotopic axis in the developing inner ear.
Authors: Mann Z, Thiede B, Chang W, Shin J, May-Simera H, Lovett M, Corwin J, Kelley M
Nat Commun, 2014;5(0):3839.
Species: Chicken
Sample Type: Whole Cells
Application: Bioassay
Inhibition of bone morphogenic protein 4 restores endothelial function in db/db diabetic mice.
Authors: Zhang Y, Liu J, Tian X, Wong W, Chen Y, Wang L, Luo J, Cheang W, Lau C, Kwan K, Wang N, Yao X, Huang Y
Arterioscler Thromb Vasc Biol, 2014;34(1):152-9.
Species: Mouse
Sample Type: Whole Organism
Application: In Vivo
Defined human pluripotent stem cell culture enables highly efficient neuroepithelium derivation without small molecule inhibitors.
Authors: Lippmann E, Estevez-Silva M, Ashton R
Stem Cells, 2014;32(4):1032-42.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Recessive mutations in a distal PTF1A enhancer cause isolated pancreatic agenesis.
Authors: Weedon M, Cebola I, Patch A, Flanagan S, De Franco E, Caswell R, Rodriguez-Segui S, Shaw-Smith C, Cho C, Lango Allen H, Houghton J, Roth C, Chen R, Hussain K, Marsh P, Vallier L, Murray A, Ellard S, Ferrer J, Hattersley A
Nat Genet, 2014;46(1):61-4.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Activation of the type I interferon pathway is enhanced in response to human neuronal differentiation.
Authors: Farmer, Jocelyn, Altschaefl, Kate M, O'Shea, K Sue, Miller, David J
PLoS ONE, 2013;8(3):e58813.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Patient-specific iPSC-derived photoreceptor precursor cells as a means to investigate retinitis pigmentosa.
Authors: Tucker, Budd A, Mullins, Robert F, Streb, Luan M, Anfinson, Kristin, Eyestone, Mari E, Kaalberg, Emily, Riker, Megan J, Drack, Arlene V, Braun, Terry A, Stone, Edwin M
Elife, 2013;2(0):e00824.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells.
Authors: Maroof A, Keros S, Tyson J, Ying S, Ganat Y, Merkle F, Liu B, Goulburn A, Stanley E, Elefanty A, Widmer H, Eggan K, Goldstein P, Anderson S, Studer L
Cell Stem Cell, 2013;12(5):559-72.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions.
Authors: Brafman D, Phung C, Kumar N, Willert K
Cell Death Differ, 2013;20(3):369-81.
Rapid and efficient directed differentiation of human pluripotent stem cells into retinal pigmented epithelium.
Authors: Buchholz, David E, Pennington, Britney, Croze, Roxanne, Hinman, Cassidy, Coffey, Peter J, Clegg, Dennis O
Stem Cells Transl Med, 2013;2(5):384-93.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Bone morphogenetic protein-2/-4 upregulation promoted by endothelial cells in coculture enhances mouse embryoid body differentiation.
Authors: Talavera-Adame, Dodanim, Gupta, Ankur, Kurtovic, Silvia, Chaiboonma, Kira L, Arumugaswami, Vaithili, Dafoe, Donald C
Stem Cells Dev, 2013;22(24):3252-60.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Enrichment of human embryonic stem cell-derived NKX6.1-expressing pancreatic progenitor cells accelerates the maturation of insulin-secreting cells in vivo.
Authors: Rezania A, Bruin J, Xu J, Narayan K, Fox J, O'Neil J, Kieffer T
Stem Cells, 2013;31(11):2432-42.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Generation of multipotent foregut stem cells from human pluripotent stem cells.
Authors: Hannan, Nicholas, Fordham, Robert P, Syed, Yasir A, Moignard, Victoria, Berry, Andrew, Bautista, Ruben, Hanley, Neil A, Jensen, Kim B, Vallier, Ludovic
Stem Cell Reports, 2013;1(4):293-306.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Cited2 gene controls pluripotency and cardiomyocyte differentiation of murine embryonic stem cells through Oct4 gene.
Authors: Li Q, Ramirez-Bergeron D, Dunwoodie S, Yang Y
J Biol Chem, 2012;287(34):29088-100.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Interplay between electrical activity and bone morphogenetic protein signaling regulates spinal neuron differentiation.
Authors: Swapna, Immani, Borodinsky, Laura N
Proc Natl Acad Sci U S A, 2012;109(40):16336-41.
Species: Xenopus
Sample Type: Whole Tissue
Application: Bioassay
Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro.
Authors: Spence JR, Mayhew CN, Rankin SA
Nature, 2011;470(7332):105-9.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Downregulation of hemojuvelin prevents inhibitory effects of bone morphogenetic proteins on iron metabolism in hepatocellular carcinoma.
Authors: Maegdefrau U, Arndt S, Kivorski G, Hellerbrand C, Bosserhoff AK
Lab. Invest., 2011;91(11):1615-23.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
A defined glycosaminoglycan-binding substratum for human pluripotent stem cells.
Authors: Klim JR, Li L, Wrighton PJ
Nat. Methods, 2010;7(12):989-94.
Species: Human
Sample Type: Whole Cells
Application: Bioassay

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