GDNF Protein 組換え体(リコンビナント)タンパク質 | Recombinant Rat GDNF Protein
掲載日情報：2018/02/07 現在Webページ番号：216016
R&D Systems社製の高品質なGDNF Proteinの組換え体タンパク質(Recombinant Rat GDNF Protein)です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 ：2024年05月25日 08時35分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
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[在庫・価格 ：2024年05月25日 08時35分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
Recombinant Rat GDNF Protein
文献数： 0
- 商品コード：512-GF-01M
- メーカー：RSD
- 包装：1mg
- 価格：ご照会ください
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 |
純度：>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.，由来動物：Rat，M.W.：15 kDa (monomer)，Genbank：2668，エンドトキシンレベル：<0.01 EU per 1 µg of the protein by the LAL method.，産生：Sf 21 (baculovirus) 別名：Astrocyte-derived trophic factor Genbank No： 2668 Protein Accession No： Q07731 |
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| 保存条件 | -20℃ | 法規備考 | |
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CF(Carrier-Free)とは？
R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。
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Product Details
- Source
- Spodoptera frugiperda, Sf 21 (baculovirus)-derivedSer78-Ile211
- Accession #
- Q07731
- Purity
- >97%, by SDS-PAGE under reducing conditions and visualized by silver stain
- Predicted Molecular Mass
- 15 kDa (monomer)
- Activity
- Astrocyte-derived trophic factor; ATF; ATF1; ATF2; GDNF; glial cell derived neurotrophic factor; glial cell line derived neurotrophic factor; glial cell line-derived neurotrophic factor; HFB1-GDNF; hGDNF; HSCR3
- Bioactivity
- Recombinant Rat GDNF (Catalog # 512‑GF) promotes the survival of chick embryonic dorsal root ganglia neurons. The ED50 for this effect is 1-3 ng/mL.
- SDS-PAGE
- 1 μg/lane of Recombinant Rat GDNF was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by silver staining, showing major bands at 19 kDa and 33 kDa, respectively.
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Related Product & Information
- Entrez Gene IDs
- 2668 (Human); 25453 (Rat)
- Background
- GDNF
- Glial Cell Line-derived Neurotrophic Factor (GDNF) is a discovered neurotrophic factor that has been shown to promote the survival of various neuronal subpopulations in both the central as well as the peripheral nervous systems at different stages of their development. Neuronal subpopulations that have been shown to be affected by GDNF include motoneurons, midbrain dopaminergic neurons, Purkinje cells and sympathetic neurons. Native GDNF, a disulfide-linked homodimeric glycoprotein, is a novel member of the TGF-beta superfamily. Rat GDNF cDNA encodes a 211 amino acid residue prepropeptide that is processed to yield a dimeric protein composed of two 134 amino acid residue subunits. The GDNF sequence contains two potential glycosylation sites and insect cell-expressed recombinant rat GDNF proteins are glycosylated. Mature rat and human GDNF exhibit approximately 93% amino acid sequence identity and show considerable species cross-reactivity. Cells known to express GDNF include Sertoli cells, type 1 astrocytes, Schwann cells, neurons, pinealocytes and skeletal muscle cells.
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Citations
R&D Systems personnel manually curate a database that contains references using R&D Systems products.
The data collected includes not only links to publications in PubMed,
but also provides information about sample types, species, and experimental conditions.
The data collected includes not only links to publications in PubMed,
but also provides information about sample types, species, and experimental conditions.
DNA methylation of the Fthl17 5'-upstream region regulates differential Fthl17 expression in lung cancer cells and germline stem cells
Authors: N Aoki, K Mochizuki, Y Matsui
PLoS ONE, 2017;12(2):e0172219.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Authors: N Aoki, K Mochizuki, Y Matsui
PLoS ONE, 2017;12(2):e0172219.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
A system to study mechanisms of neuromuscular junction development and maintenance
Development, 2016;0(0):.
Species: Rat
Sample Type: Whole Tissue
Application: Bioassay
Development, 2016;0(0):.
Species: Rat
Sample Type: Whole Tissue
Application: Bioassay
Loss of MAX results in meiotic entry in mouse embryonic and germline stem cells
Authors: A Suzuki, M Hirasaki, T Hishida, J Wu, D Okamura, A Ueda, M Nishimoto, Y Nakachi, Y Mizuno, Y Okazaki, Y Matsui, JC Izpisua Be, A Okuda
Nat Commun, 2016;7(0):11056.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Authors: A Suzuki, M Hirasaki, T Hishida, J Wu, D Okamura, A Ueda, M Nishimoto, Y Nakachi, Y Mizuno, Y Okazaki, Y Matsui, JC Izpisua Be, A Okuda
Nat Commun, 2016;7(0):11056.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
In�Vitro Derivation and Propagation of Spermatogonial Stem Cell Activity from Mouse Pluripotent Stem Cells
Cell Rep, 2016;17(10):2789-2804.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Cell Rep, 2016;17(10):2789-2804.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Novel Kidins220/ARMS Splice Isoforms: Potential Specific Regulators of Neuronal and Cardiovascular Development.
Authors: Schmieg N, Thomas C, Yabe A, Lynch D, Iglesias T, Chakravarty P, Schiavo G
PLoS ONE, 2015;10(6):e0129944.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Authors: Schmieg N, Thomas C, Yabe A, Lynch D, Iglesias T, Chakravarty P, Schiavo G
PLoS ONE, 2015;10(6):e0129944.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Spermatogonial stem cell enrichment using simple grafting of testis and in vitro cultivation.
Authors: Lim, Jung Jin, Seol, Dong Won, Choi, Kyung He, Shin, Dong Hyu, Kim, Hyung Jo, Song, Seung-Hu, Lee, Dong Ryu
Sci Rep, 2014;4(0):5923.
Species: Mouse
Sample Type: Whole Tissue
Application: Bioassay
Authors: Lim, Jung Jin, Seol, Dong Won, Choi, Kyung He, Shin, Dong Hyu, Kim, Hyung Jo, Song, Seung-Hu, Lee, Dong Ryu
Sci Rep, 2014;4(0):5923.
Species: Mouse
Sample Type: Whole Tissue
Application: Bioassay
Bicaudal-D1 regulates the intracellular sorting and signalling of neurotrophin receptors.
Authors: Terenzio M, Golding M, Russell M, Wicher K, Rosewell I, Spencer-Dene B, Ish-Horowicz D, Schiavo G
EMBO J, 2014;33(14):1582-98.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Authors: Terenzio M, Golding M, Russell M, Wicher K, Rosewell I, Spencer-Dene B, Ish-Horowicz D, Schiavo G
EMBO J, 2014;33(14):1582-98.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Three-step method for proliferation and differentiation of human embryonic stem cell (hESC)-derived male germ cells.
Authors: Lim J, Shim M, Lee J, Lee D
PLoS ONE, 2014;9(4):e90454.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Lim J, Shim M, Lee J, Lee D
PLoS ONE, 2014;9(4):e90454.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
The neurotrophic factor receptor RET drives haematopoietic stem cell survival and function.
Authors: Fonseca-Pereira D, Arroz-Madeira S, Rodrigues-Campos M, Barbosa I, Domingues R, Bento T, Almeida A, Ribeiro H, Potocnik A, Enomoto H, Veiga-Fernandes H
Nature, 2014;514(7520):98-101.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Authors: Fonseca-Pereira D, Arroz-Madeira S, Rodrigues-Campos M, Barbosa I, Domingues R, Bento T, Almeida A, Ribeiro H, Potocnik A, Enomoto H, Veiga-Fernandes H
Nature, 2014;514(7520):98-101.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
The niche-derived glial cell line-derived neurotrophic factor (GDNF) induces migration of mouse spermatogonial stem/progenitor cells.
Authors: Dovere, Lisa, Fera, Stefania, Grasso, Margheri, Lamberti, Dante, Gargioli, Cesare, Muciaccia, Barbara, Lustri, Anna Mar, Stefanini, Mario, Vicini, Elena
PLoS ONE, 2013;8(4):e59431.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Authors: Dovere, Lisa, Fera, Stefania, Grasso, Margheri, Lamberti, Dante, Gargioli, Cesare, Muciaccia, Barbara, Lustri, Anna Mar, Stefanini, Mario, Vicini, Elena
PLoS ONE, 2013;8(4):e59431.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Differential targeting of the dopamine transporter to recycling or degradative pathways during amphetamine- or PKC-regulated endocytosis in dopamine neurons.
Authors: Hong, Weimin C, Amara, Susan G
FASEB J, 2013;27(8):2995-3007.
Species: Rat
Sample Type: Whole Cells
Application: Bioassay
Authors: Hong, Weimin C, Amara, Susan G
FASEB J, 2013;27(8):2995-3007.
Species: Rat
Sample Type: Whole Cells
Application: Bioassay
Substrate specificity of R3 receptor-like protein-tyrosine phosphatase subfamily toward receptor protein-tyrosine kinases.
Authors: Sakuraba, Juichi, Shintani, Takafumi, Tani, Sachiko, Noda, Masaharu
J Biol Chem, 2013;288(32):23421-31.
Species: Rat
Sample Type: Whole Cells
Application: Bioassay
Authors: Sakuraba, Juichi, Shintani, Takafumi, Tani, Sachiko, Noda, Masaharu
J Biol Chem, 2013;288(32):23421-31.
Species: Rat
Sample Type: Whole Cells
Application: Bioassay
Glial cell line-derived neurotrophic factor (GDNF) induces neuritogenesis in the cochlear spiral ganglion via neural cell adhesion molecule (NCAM).
Authors: Euteneuer S, Yang K, Chavez E, Leichtle A, Loers G, Olshansky A, Pak K, Schachner M, Ryan A
Mol Cell Neurosci, 2013;54(0):30-43.
Species: Rat
Sample Type: Whole Tissue
Application: Bioassay
Authors: Euteneuer S, Yang K, Chavez E, Leichtle A, Loers G, Olshansky A, Pak K, Schachner M, Ryan A
Mol Cell Neurosci, 2013;54(0):30-43.
Species: Rat
Sample Type: Whole Tissue
Application: Bioassay
Non-viral gene therapy for GDNF production in RCS rat: the crucial role of the plasmid dose.
Gene Ther., 2012;19(9):886-98.
Species: N/A
Sample Type: N/A
Application: ELISA Standard
Gene Ther., 2012;19(9):886-98.
Species: N/A
Sample Type: N/A
Application: ELISA Standard
Isolation and propagation of enteric neural crest progenitor cells from mouse embryonic stem cells and embryos.
Authors: Kawaguchi J, Nichols J, Gierl MS, Faial T, Smith A
Development, 2010;137(5):693-704.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Authors: Kawaguchi J, Nichols J, Gierl MS, Faial T, Smith A
Development, 2010;137(5):693-704.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Long-term culture of male germline stem cells from hamster testes.
Authors: Kanatsu-Shinohara M, Muneto T, Lee J, Takenaka M, Chuma S, Nakatsuji N, Horiuchi T, Shinohara T
Biol. Reprod., 2007;78(4):611-7.
Species: Hamster
Sample Type: Whole Cells
Application: Bioassay
Authors: Kanatsu-Shinohara M, Muneto T, Lee J, Takenaka M, Chuma S, Nakatsuji N, Horiuchi T, Shinohara T
Biol. Reprod., 2007;78(4):611-7.
Species: Hamster
Sample Type: Whole Cells
Application: Bioassay
Gdnf upregulates c-Fos transcription via the Ras/Erk1/2 pathway to promote mouse spermatogonial stem cell proliferation.
Authors: He Z, Jiang J, Kokkinaki M, Golestaneh N, Hofmann MC, Dym M
Stem Cells, 2007;26(1):266-78.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Authors: He Z, Jiang J, Kokkinaki M, Golestaneh N, Hofmann MC, Dym M
Stem Cells, 2007;26(1):266-78.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Identification of neuregulin as a factor required for formation of aligned spermatogonia.
Authors: Hamra FK, Chapman KM, Nguyen D, Garbers DL
J. Biol. Chem., 2007;282(1):721-30.
Species: Rat
Sample Type: Whole Cells
Application: Bioassay
Authors: Hamra FK, Chapman KM, Nguyen D, Garbers DL
J. Biol. Chem., 2007;282(1):721-30.
Species: Rat
Sample Type: Whole Cells
Application: Bioassay
Purification of bioactive glycosylated recombinant glial cell line-derived neurotrophic factor.
Authors: Garbayo E, Ansorena E, Lanciego JL, Aymerich MS, Blanco-Prieto MJ
Int J Pharm, 2007;344(1):9-15.
Species: N/A
Sample Type: N/A
Application: WB Ctrl
Authors: Garbayo E, Ansorena E, Lanciego JL, Aymerich MS, Blanco-Prieto MJ
Int J Pharm, 2007;344(1):9-15.
Species: N/A
Sample Type: N/A
Application: WB Ctrl
Protective effects of neurotrophic factors on tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis of murine adrenal chromaffin cell line tsAM5D.
Authors: Murata T, Tsuboi M, Hikita K, Kaneda N
J. Biol. Chem., 2006;281(32):22503-16.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Authors: Murata T, Tsuboi M, Hikita K, Kaneda N
J. Biol. Chem., 2006;281(32):22503-16.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Glial cell line-derived neurotrophic factor (GDNF) receptor alpha-1 (GFR alpha 1) is highly selective for GDNF versus artemin.
Authors: Carmillo P, Dago L, Day ES, Worley DS, Rossomando A, Walus L, Orozco O, Buckley C, Miller S, Tse A, Cate RL, Rosenblad C, Sah DW, Gronborg M, Whitty A
Biochemistry, 2005;44(7):2545-54.
Species: Rat
Sample Type: Whole Cells
Application: Bioassay
Authors: Carmillo P, Dago L, Day ES, Worley DS, Rossomando A, Walus L, Orozco O, Buckley C, Miller S, Tse A, Cate RL, Rosenblad C, Sah DW, Gronborg M, Whitty A
Biochemistry, 2005;44(7):2545-54.
Species: Rat
Sample Type: Whole Cells
Application: Bioassay
TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury.
Authors: Obata K, Katsura H, Mizushima T, Yamanaka H, Kobayashi K, Dai Y, Fukuoka T, Tokunaga A, Tominaga M, Noguchi K
J. Clin. Invest., 2005;115(9):2393-401.
Species: Rat
Sample Type: In Vivo
Application: In Vivo
Authors: Obata K, Katsura H, Mizushima T, Yamanaka H, Kobayashi K, Dai Y, Fukuoka T, Tokunaga A, Tominaga M, Noguchi K
J. Clin. Invest., 2005;115(9):2393-401.
Species: Rat
Sample Type: In Vivo
Application: In Vivo
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