Recombinant, Carrier-free 組換え体(リコンビナント)タンパク質 | MIF, Human, Recombinant, Carrier-free
掲載日情報：2018/02/07 現在Webページ番号：215995
R&D Systems社製の高品質なRecombinant, Carrier-free
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 ：2025年05月01日 08時55分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
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MIF, Human, Recombinant, Carrier-free <Macrophage Migration Inhibitory Factor> |
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Recombinant Human MIF Protein, CF |
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[在庫・価格 ：2025年05月01日 08時55分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
MIF, Human, Recombinant, Carrier-free <Macrophage Migration Inhibitory Factor>
文献数： 0
- 商品コード：289-MF-002/CF
- メーカー：RSD
- 包装：2μg
- 価格：¥29,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | 純度：>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.，由来動物：Human，M.W.：12.4 kDa & 12.3 kDa，Genbank：4282，エンドトキシンレベル：<0.10 EU per 1 µg of the protein by the LAL method.，産生：E. coli 別名：EC 5.3.2.1 Genbank No： 4282 Protein Accession No： AAA36315 |
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| 保存条件 | -20℃ | 法規備考 | |
| 掲載カタログ |
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| 製品記事 | MIF 組換え体(リコンビナント)タンパク質 | Recombinant Human MIF |
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Recombinant Human MIF Protein, CF
文献数： 0
- 商品コード：289-MF-01M/CF
- メーカー：RSD
- 包装：1mg
- 価格：ご照会ください
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | 純度：>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.，由来動物：Human，M.W.：12.4 kDa & 12.3 kDa，Genbank：4282，エンドトキシンレベル：<0.10 EU per 1 µg of the protein by the LAL method.，産生：E. coli 別名：EC 5.3.2.1 Genbank No： 4282 Protein Accession No： AAA36315 |
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| 法規制等 | |||
| 保存条件 | -20℃ | 法規備考 | |
| 掲載カタログ |
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| 関連記事 | |||
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CF(Carrier-Free)とは？
R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。
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Product Details
- Source
- E. coli-derivedPro2-Ala115, with an N-terminal Met
- Accession #
- AAA36315
- Purity
- >97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
- Predicted Molecular Mass
- 12.4 kDa & 12.3 kDa
- Activity
- Bioassay data are not available.
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Related Product & Information
- Entrez Gene IDs
- 4282 (Human); 17319 (Mouse)
- Background
- MIF
- MIF (or macrophage migration inhibitory factor) was the first lymphokine/cytokine to be recognized in the pregenomics era (1, 2). Regardless, it is one of the least understood of all inflammatory mediators (1, 3). Human MIF is a 12.5 kDa, 115 amino acid (aa) nonglycosylated polypeptide that is synthesized without a signal sequence (4 - 7). Secretion occurs nonclassically via an ABCA1 transporter (8). The initiating Met is removed, leaving Pro as the first amino acid. The molecule consists of two alpha -helices and six beta -strands, four of which form a beta -sheet. The two remaining beta -strands interact with other MIF molecules, creating a trimer (2, 9, 10). Structure-function studies suggest MIF is bifunctional with segregated topology. The N- and C-termini mediate enzyme activity (in theory). Phenylpyruvate tautomerase activity (enol-to-keto) has been demonstrated and is dependent upon Pro at position #1 (11). Amino acids 50 - 65 have also been suggested to contain thiol-protein oxidoreductase activity (12). MIF has proinflammatory cytokine activity centered around aa’s 49 - 65. On fibroblasts, MIF induces, IL-1, IL-8 and MMP expression; on macrophages, MIF stimulates NO production and TNF-alpha release following IFN-gamma activation (13, 14). MIF apparently acts through CD74 and CD44, likely in some form of trimeric interaction (15, 16). Human MIF is active on mouse cells (14). Human MIF is 90%, 94%, 95%, and 90% aa identical to mouse, bovine, porcine and rat MIF, respectively.
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Citations
R&D Systems personnel manually curate a database that contains references using R&D Systems products.
The data collected includes not only links to publications in PubMed,
but also provides information about sample types, species, and experimental conditions.
The data collected includes not only links to publications in PubMed,
but also provides information about sample types, species, and experimental conditions.
Modulating glioma-mediated myeloid-derived suppressor cell development with sulforaphane
Authors: R Kumar, T de Mooij, TE Peterson, T Kaptzan, AJ Johnson, DJ Daniels, IF Parney
PLoS ONE, 2017;12(6):e0179012.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: R Kumar, T de Mooij, TE Peterson, T Kaptzan, AJ Johnson, DJ Daniels, IF Parney
PLoS ONE, 2017;12(6):e0179012.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Inhibition of T-cell activation by retinal pigment epithelial cells derived from induced pluripotent stem cells.
Authors: Sugita S, Kamao H, Iwasaki Y, Okamoto S, Hashiguchi T, Iseki K, Hayashi N, Mandai M, Takahashi M
Invest Ophthalmol Vis Sci, 2015;56(2):1051-62.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Sugita S, Kamao H, Iwasaki Y, Okamoto S, Hashiguchi T, Iseki K, Hayashi N, Mandai M, Takahashi M
Invest Ophthalmol Vis Sci, 2015;56(2):1051-62.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
HIF1alpha-Induced by Lysophosphatidic Acid Is Stabilized via Interaction with MIF and CSN5.
Authors: No Y, Lee S, Kumar A, Yun C
PLoS ONE, 2015;10(9):e0137513.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: No Y, Lee S, Kumar A, Yun C
PLoS ONE, 2015;10(9):e0137513.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
The expression of HIV-1 Vpu in monocytes causes increased secretion of TGF-beta that activates profibrogenic genes in hepatic stellate cells.
Authors: Patel P, Khan N, Rani M, Gupta D, Jameel S
PLoS ONE, 2014;9(2):e88934.
Authors: Patel P, Khan N, Rani M, Gupta D, Jameel S
PLoS ONE, 2014;9(2):e88934.
Tumor Microenvironment Macrophage Inhibitory Factor Directs the Accumulation of Interleukin-17-producing Tumor-infiltrating Lymphocytes and Predicts Favorable Survival in Nasopharyngeal Carcinoma Patients.
Authors: Li J, Mo H, Xiong G, Zhang L, He J, Huang Z, Liu Z, Chen Q, Du Z, Zheng L, Qian C, Zeng Y
J Biol Chem, 2012;287(42):35484-95.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Li J, Mo H, Xiong G, Zhang L, He J, Huang Z, Liu Z, Chen Q, Du Z, Zheng L, Qian C, Zeng Y
J Biol Chem, 2012;287(42):35484-95.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Critical role for macrophage migration inhibitory factor (MIF) in Ross River virus-induced arthritis and myositis.
Authors: Herrero LJ, Nelson M, Srikiatkhachorn A, Gu R, Anantapreecha S, Fingerle-Rowson G, Bucala R, Morand E, Santos LL, Mahalingam S
Proc. Natl. Acad. Sci. U.S.A., 2011;108(29):12048-53.
Species: Mouse
Sample Type: In Vivo
Application: In Vivo
Authors: Herrero LJ, Nelson M, Srikiatkhachorn A, Gu R, Anantapreecha S, Fingerle-Rowson G, Bucala R, Morand E, Santos LL, Mahalingam S
Proc. Natl. Acad. Sci. U.S.A., 2011;108(29):12048-53.
Species: Mouse
Sample Type: In Vivo
Application: In Vivo
Human CD4- 8- T cells are a distinctive immunoregulatory subset.
Authors: Huang MC, Patel K, Taub DD, Longo DL, Goetzl EJ
FASEB J., 2010;24(7):2558-66.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Huang MC, Patel K, Taub DD, Longo DL, Goetzl EJ
FASEB J., 2010;24(7):2558-66.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
A multiplex immunoassay for human adipokine profiling.
Authors: Schipper HS, De Jager W, van Dijk ME, Meerding J, Zelissen PM, Adan RA, Prakken BJ, Kalkhoven E
Clin. Chem., 2010;56(0):1320.
Authors: Schipper HS, De Jager W, van Dijk ME, Meerding J, Zelissen PM, Adan RA, Prakken BJ, Kalkhoven E
Clin. Chem., 2010;56(0):1320.
Thrombin induced secretion of macrophage migration inhibitory factor (MIF) and its effect on nuclear signaling in endothelium.
Authors: Wadgaonkar R, Somnay K, Garcia JG
J. Cell. Biochem., 2008;105(5):1279-88.
Species: Bovine
Sample Type: Whole Cells
Application: Bioassay
Authors: Wadgaonkar R, Somnay K, Garcia JG
J. Cell. Biochem., 2008;105(5):1279-88.
Species: Bovine
Sample Type: Whole Cells
Application: Bioassay
Sex dimorphism in wound healing: the roles of sex steroids and macrophage migration inhibitory factor.
Authors: Gilliver SC, Ruckshanthi JP, Hardman MJ, Nakayama T, Ashcroft GS
Endocrinology, 2008;149(11):5747-57.
Species: Mouse
Sample Type: In Vivo
Application: In Vivo
Authors: Gilliver SC, Ruckshanthi JP, Hardman MJ, Nakayama T, Ashcroft GS
Endocrinology, 2008;149(11):5747-57.
Species: Mouse
Sample Type: In Vivo
Application: In Vivo
UVA induces granzyme B in human keratinocytes through MIF: implication in extracellular matrix remodeling.
Authors: Hernandez-Pigeon H, Jean C, Charruyer A, Haure MJ, Baudouin C, Charveron M, Quillet-Mary A, Laurent G
J. Biol. Chem., 2007;282(11):8157-64.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Hernandez-Pigeon H, Jean C, Charruyer A, Haure MJ, Baudouin C, Charveron M, Quillet-Mary A, Laurent G
J. Biol. Chem., 2007;282(11):8157-64.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Migration inhibitory factor up-regulates vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 via Src, PI3 kinase, and NFkappaB.
Authors: Amin MA, Haas CS, Zhu K, Mansfield PJ, Kim MJ, Lackowski NP, Koch AE
Blood, 2006;107(6):2252-61.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Amin MA, Haas CS, Zhu K, Mansfield PJ, Kim MJ, Lackowski NP, Koch AE
Blood, 2006;107(6):2252-61.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Elevated macrophage migration inhibitory factor (MIF) levels in the urine of patients with focal glomerular sclerosis.
Authors: Matsumoto K, Maruyama N, Maruyama T, Ohnishi Y, Nonaka S, Inoshita A, Ito K, Kitajima S, Abe M, Satomura A, Fujita T
Clin. Exp. Immunol., 2005;139(2):338-47.
Species: N/A
Sample Type: N/A
Application: ELISA Standard
Authors: Matsumoto K, Maruyama N, Maruyama T, Ohnishi Y, Nonaka S, Inoshita A, Ito K, Kitajima S, Abe M, Satomura A, Fujita T
Clin. Exp. Immunol., 2005;139(2):338-47.
Species: N/A
Sample Type: N/A
Application: ELISA Standard
Variation in macrophage-migration-inhibitory-factor immunoreactivity during porcine gestation.
Authors: Paulesu L, Cateni C, Romagnoli R, Ietta F, Dantzer V
Biol. Reprod., 2005;72(4):949-53.
Species: N/A
Sample Type: N/A
Application: WB Ctrl
Authors: Paulesu L, Cateni C, Romagnoli R, Ietta F, Dantzer V
Biol. Reprod., 2005;72(4):949-53.
Species: N/A
Sample Type: N/A
Application: WB Ctrl
High concentrations of circulating macrophage migration inhibitory factor in patients with severe blunt trauma: Is serum macrophage migration inhibitory factor concentration a valuable prognostic factor?
Authors: Chuang CC, Hung CJ, Tsai MC, Chuang YC
Crit. Care Med., 2004;32(3):734-9.
Application: ELISA Standard
Authors: Chuang CC, Hung CJ, Tsai MC, Chuang YC
Crit. Care Med., 2004;32(3):734-9.
Application: ELISA Standard
Estrogen modulates cutaneous wound healing by downregulating macrophage migration inhibitory factor.
Authors: Ashcroft GS, Mills SJ, Lei K, Gibbons L, Jeong MJ, Taniguchi M, Burow M, Horan MA, Wahl SM, Nakayama T
J. Clin. Invest., 2003;111(9):1309-18.
Species: Mouse
Sample Type: In Vivo
Application: In Vivo
Authors: Ashcroft GS, Mills SJ, Lei K, Gibbons L, Jeong MJ, Taniguchi M, Burow M, Horan MA, Wahl SM, Nakayama T
J. Clin. Invest., 2003;111(9):1309-18.
Species: Mouse
Sample Type: In Vivo
Application: In Vivo
Human V gamma 2V delta 2 T cells augment migration-inhibitory factor secretion and counteract the inhibitory effect of glucocorticoids on IL-1 beta and TNF-alpha production.
Authors: Wang L, Das H, Kamath A, Li L, Bukowski JF
J. Immunol., 2002;168(10):4889-96.
Species: N/A
Sample Type: N/A
Application: ELISA Standard
Authors: Wang L, Das H, Kamath A, Li L, Bukowski JF
J. Immunol., 2002;168(10):4889-96.
Species: N/A
Sample Type: N/A
Application: ELISA Standard
Urinary levels of macrophage migration inhibitory factor in patients with IgA nephropathy.
Authors: Matsumoto K, Kanmatsuse K
Nephron, 2002;92(2):309-15.
Species: N/A
Sample Type: N/A
Application: ELISA Standard
Authors: Matsumoto K, Kanmatsuse K
Nephron, 2002;92(2):309-15.
Species: N/A
Sample Type: N/A
Application: ELISA Standard
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製品情報は掲載時点のものですが、価格表内の価格については随時最新のものに更新されます。お問い合わせいただくタイミングにより製品情報・価格などは変更されている場合があります。
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