BDNF Protein 組換え体(リコンビナント)タンパク質 | Recombinant Human/Mouse/Rat/Canine/Equine BDNF Protein
掲載日情報:2018/02/07 現在Webページ番号:215989
R&D Systems社製の高品質なBDNF Proteinの組換え体タンパク質(Recombinant Human/Mouse/Rat/Canine/Equine BDNF Protein)です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 :2025年05月06日 15時55分現在]
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Recombinant Human BDNF Protein |
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Recombinant Human BDNF Protein, CF |
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[在庫・価格 :2025年05月06日 15時55分現在]
Recombinant Human BDNF Protein
文献数: 0
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バルク注文に関して
※バルク包装品も承ります。お気軽にお問合せ下さい。
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CF(Carrier-Free)とは?
R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。
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Product Details
- Source
- Spodoptera frugiperda, Sf 21 (baculovirus)-derivedHis129-Arg247
- Accession #
- P23560
- Purity
- >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Predicted Molecular Mass
- 13.5 kDa
- SDS-PAGE
- 13-14 kDa, reducing conditions
- Activity
- Abrineurin; ANON2; BDNF; brain-derived neurotrophic factor; BULN2; MGC34632; neurotrophin
- Bioactivity
- Recombinant Human BDNF (Catalog #248‑BD) stimulates cell proliferation in the BaF mouse pro-B cell line transfected with TrkB. The ED50 for this effect is 0.2-2 ng/mL.
- SDS-PAGE
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Related Product & Information
- Entrez Gene IDs
- 627 (Human); 12064 (Mouse); 24225 (Rat)
- Background
- BDNF
- Brain-derived neurotrophic factor (BDNF) is a member of the NGF family of neurotrophic factors (also named neurotrophins) that are required for the differentiation and survival of specific neuronal subpopulations in both the central as well as the peripheral nervous system. The neurotrophin family is comprised of at least four proteins including NGF, BDNF, NT-3, and NT-4/5. These secreted cytokines are synthesized as prepropeptides that are proteolytically processed to generate the mature proteins (1, 2). All neurotrophins have six conserved cysteine residues that are involved in the formation of three disulfide bonds and all share approximately 55% sequence identity at the amino acid level. Similarly to NGF, bioactive BDNF is predicted to be a non-covalently linked homodimer. BDNF cDNA encodes a 247 amino acid residue precursor protein with a signal peptide and a proprotein that are cleaved to yield the 119 amino acid residue mature BDNF. The amino acid sequence of mature BDNF is identical in all mammals examined. High levels of expression of BDNF have been detected in the hippocampus, cerebellum, fetal eye and placenta. In addition, low levels of BDNF expression are also found in the pituitary gland, spinal cord, heart, lung and skeletal muscle. BDNF binds with high affinity and specifically activates the TrkB tyrosine kinase receptor (3).
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Citations
The data collected includes not only links to publications in PubMed,
but also provides information about sample types, species, and experimental conditions.
Authors: KY Tseng, JE Anttila, K Khodosevic, RK Tuominen, M Lindahl, A Domanskyi, M Airavaara
Mol. Ther., 2017;0(0):.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Authors: A Kaminari, N Giannakas, A Tzinia, EC Tsilibary
Sci Rep, 2017;7(1):683.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Authors: Y Qi, XJ Zhang, N Renier, Z Wu, T Atkin, Z Sun, MZ Ozair, J Tchieu, B Zimmer, F Fattahi, Y Ganat, R Azevedo, N Zeltner, AH Brivanlou, M Karayiorgo, J Gogos, M Tomishima, M Tessier-La, SH Shi, L Studer
Nat. Biotechnol, 2017;0(0):.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: SA Liddelow, KA Guttenplan, LE Clarke, FC Bennett, CJ Bohlen, L Schirmer, ML Bennett, AE Mnch, WS Chung, TC Peterson, DK Wilton, A Frouin, BA Napier, N Panicker, M Kumar, MS Buckwalter, DH Rowitch, VL Dawson, TM Dawson, B Stevens, BA Barres
Nature, 2017;541(7638):481-487.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: X Yuan, Z Li, AC Baines, E Gavriilaki, Z Ye, Z Wen, EM Braunstein, LG Biesecker, L Cheng, X Dong, RA Brodsky
PLoS ONE, 2017;12(4):e0174074.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: SP Jenkinson, D Grandgirar, M Heidemann, A Tscherter, MA Avondet, SL Leib
Front Pharmacol, 2017;8(0):73.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Authors: L Guillaud, D Dimitrov, T Takahashi
Elife, 2017;6(0):.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: S Schaller, D Buttigieg, A Alory, A Jacquier, M Barad, M Merchant, D Gentien, P de la Gran, G Haase
Proc. Natl. Acad. Sci. U.S.A, 2017;114(12):E2486-E2493.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Authors: W Wu, XL Wu, YQ Ji, Z Gao
Mol Med Rep, 2017;0(0):.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: K Burk, JD Murdoch, S Freytag, M Koenig, V Bharat, R Markworth, S Burkhardt, A Fischer, C Dean
Sci Rep, 2017;7(1):2149.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Authors: N Zeltner, F Fattahi, NC Dubois, N Saurat, F Lafaille, L Shang, B Zimmer, J Tchieu, MA Soliman, G Lee, JL Casanova, L Studer
Nat. Med., 2016;22(12):1421-1427.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Sci Rep, 2016;6(0):31063.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Z Zhao, Y Ma, Z Chen, Q Liu, Q Li, D Kong, K Yuan, L Hu, T Wang, X Chen, Y Peng, W Jiang, Y Yu, X Liu
Front Cell Neurosci, 2016;10(0):291.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Sci Rep, 2016;6(0):32532.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Stem Cell Res, 2016;17(3):526-530.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Sci Rep, 2016;6(0):36529.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
J Neurosci, 2016;36(17):4816-31.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: G Stratigopo, LC Burnett, R Rausch, R Gill, DB Penn, AA Skowronski, CA LeDuc, AJ Lanzano, P Zhang, DR Storm, D Egli, RL Leibel
J Clin Invest, 2016;0(0):.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Authors: Eva Hedlund
Sci Rep, 2016;6(0):26448.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Authors: Lim M, Chang M, Kim S, Yi S, Suh-Kim H, Jung S, Kim M, Kim J, Lee Y, Lee S, Kim D, Lee S, Park C
J Biol Chem, 2015;290(28):17401-14.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Authors: Yoshida M, Kitaoka S, Egawa N, Yamane M, Ikeda R, Tsukita K, Amano N, Watanabe A, Morimoto M, Takahashi J, Hosoi H, Nakahata T, Inoue H, Saito M
Stem Cell Reports, 2015;4(4):561-8.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Devlin, Anna-Cla, Burr, Karen, Borooah, Shyamang, Foster, Joshua D, Cleary, Elaine M, Geti, Imbisaat, Vallier, Ludovic, Shaw, Christop, Chandran, Siddhart, Miles, Gareth B
Nat Commun, 2015;6(0):5999.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Hartman W, Helan M, Smelter D, Sathish V, Thompson M, Pabelick C, Johnson B, Prakash Y
PLoS ONE, 2015;10(7):e0129489.
Species: Human
Sample Type: Whole Tissue
Application: Bioassay
Authors: Lim M, Shin M, Lee S, Minn Y, Hoh J, Cho Y, Kim D, Lee S, Kim C, Park C
PLoS ONE, 2015;10(9):e0138460.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Czarnecka M, Trinh E, Lu C, Kuan-Celarier A, Galli S, Hong S, Tilan J, Talisman N, Izycka-Swieszewska E, Tsuei J, Yang C, Martin S, Horton M, Christian D, Everhart L, Maheswaran I, Kitlinska J
Oncogene, 2015;34(24):3131-43.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Laguna A, Schintu N, Nobre A, Alvarsson A, Volakakis N, Jacobsen J, Gomez-Galan M, Sopova E, Joodmardi E, Yoshitake T, Deng Q, Kehr J, Ericson J, Svenningsson P, Shupliakov O, Perlmann T
Nat Neurosci, 2015;18(6):826-35.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Authors: Merkle F, Maroof A, Wataya T, Sasai Y, Studer L, Eggan K, Schier A
Development, 2015;142(4):633-43.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Tanaka, Taku, Yokoi, Tadashi, Tamalu, Fuminobu, Watanabe, Shu-Ichi, Nishina, Sachiko, Azuma, Noriyuki
Sci Rep, 2015;5(0):8344.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Chen, Long-Xia, Ma, Si-Min, Zhang, Peng, Fan, Zi-Chuan, Xiong, Man, Cheng, Guo-Qian, Yang, Yi, Qiu, Zi-Long, Zhou, Wen-Hao, Li, Jin
PLoS ONE, 2015;10(3):e0115997.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Authors: Wainger B, Buttermore E, Oliveira J, Mellin C, Lee S, Saber W, Wang A, Ichida J, Chiu I, Barrett L, Huebner E, Bilgin C, Tsujimoto N, Brenneis C, Kapur K, Rubin L, Eggan K, Woolf C
Nat Neurosci, 2015;18(1):17-24.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Authors: Pereira, Maria, Pfisterer, Ulrich, Rylander, Daniella, Torper, Olof, Lau, Shong, Lundblad, Martin, Grealish, Shane, Parmar, Malin
Sci Rep, 2014;4(0):6330.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Dewitt J, Ochoa V, Urschitz J, Elston M, Moisyadi S, Nishi R
Oncogene, 2014;33(8):977-85.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Otis J, Fitzgerald M, Mueller D
J Neurosci, 2014;34(17):6057-64.
Species: Rat
Sample Type: In Vivo
Application: In Vivo
Authors: Bayin, N Sumru, Modrek, Aram S, Dietrich, August, Lebowitz, Jonathan, Abel, Tobias, Song, Hae-Ri, Schober, Markus, Zagzag, David, Buchholz, Christia, Chao, Moses V, Placantonakis, Dimitris
PLoS ONE, 2014;9(12):e116114.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Dana, Hod, Marom, Anat, Paluch, Shir, Dvorkin, Roman, Brosh, Inbar, Shoham, Shy
Nat Commun, 2014;5(0):3997.
Species: Rat
Sample Type: Whole Cells
Application: Bioassay
Authors: Pre D, Nestor M, Sproul A, Jacob S, Koppensteiner P, Chinchalongporn V, Zimmer M, Yamamoto A, Noggle S, Arancio O
PLoS ONE, 2014;9(7):e103418.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Terenzio M, Golding M, Russell M, Wicher K, Rosewell I, Spencer-Dene B, Ish-Horowicz D, Schiavo G
EMBO J, 2014;33(14):1582-98.
Species: N/A
Sample Type: Protein
Application: WB Standard
Authors: Kaneko A, Sankai Y
PLoS ONE, 2014;9(7):e102703.
Species: Rat
Sample Type: Whole Tissue
Application: Bioassay
Authors: Zhou, Zhi, Kohda, Kazuhisa, Ibata, Keiji, Kohyama, Jun, Akamatsu, Wado, Yuzaki, Michisuk, Okano, Hirotaka, Sasaki, Erika, Okano, Hideyuki
Mol Brain, 2014;7(0):24.
Species: Primate - Callitrix jacchus (Common Marmoset)
Sample Type: Whole Cells
Application: Bioassay
Authors: Chang, Ki-Young, Woo, Doyeon, Jung, Hyunjin, Lee, Sangkyu, Kim, Sungsoo, Won, Joungha, Kyung, Taeyoon, Park, Hyerim, Kim, Nury, Yang, Hee Won, Park, Jae-Yong, Hwang, Eun Mi, Kim, Daesoo, Heo, Won Do
Nat Commun, 2014;5(0):4057.
Species: Rat
Sample Type: Whole Cells
Application: Bioassay
Authors: Melemedjian O, Tillu D, Moy J, Asiedu M, Mandell E, Ghosh S, Dussor G, Price T
Mol Pain, 2014;10(0):45.
Species: Mouse
Sample Type: In Vivo
Application: In Vivo
Authors: Osborne, Jihan K, Larsen, Jill E, Shields, Misty D, Gonzales, Joshua X, Shames, David S, Sato, Mitsuo, Kulkarni, Ashwinik, Wistuba, Ignacio, Girard, Luc, Minna, John D, Cobb, Melanie
Proc Natl Acad Sci U S A, 2013;110(16):6524-9.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Ni, Na, Hu, Yaohua, Ren, Huixia, Luo, Chuanmin, Li, Peng, Wan, Jian-Bo, Su, Huanxing
PLoS ONE, 2013;8(12):e84504.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Authors: Stappert L, Borghese L, Roese-Koerner B, Weinhold S, Koch P, Terstegge S, Uhrberg M, Wernet P, Brustle O
PLoS ONE, 2013;8(3):e59011.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Liu Y, Weick J, Liu H, Krencik R, Zhang X, Ma L, Zhou G, Ayala M, Zhang S
Nat Biotechnol, 2013;31(5):440-7.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Howard, Laura, Wyatt, Sean, Nagappan, Guhan, Davies, Alun M
Development, 2013;140(10):2108-17.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Authors: Najm, Fadi J, Lager, Angela M, Zaremba, Anita, Wyatt, Krysta, Caprariello, Andrew V, Factor, Daniel C, Karl, Robert T, Maeda, Tadao, Miller, Robert H, Tesar, Paul J
Nat Biotechnol, 2013;31(5):426-33.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Authors: Shim, Joong Hy, Lee, Tae Ryon, Shin, Dong Woo
Stem Cells Dev, 2013;22(8):1264-74.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Gatto G, Dudanova I, Suetterlin P, Davies A, Drescher U, Bixby J, Klein R
J Neurosci, 2013;33(12):5399-410.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Authors: Yang Y, Gupta S, Kim K, Powers B, Cerqueira A, Wainger B, Ngo H, Rosowski K, Schein P, Ackeifi C, Arvanites A, Davidow L, Woolf C, Rubin L
Cell Stem Cell, 2013;12(6):713-26.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Martin, Sally, Harper, Callista, May, Linda M, Coulson, Elizabet, Meunier, Frederic, Osborne, Shona L
PLoS ONE, 2013;8(3):e60152.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Authors: Higurashi N, Uchida T, Lossin C, Misumi Y, Okada Y, Akamatsu W, Imaizumi Y, Zhang B, Nabeshima K, Mori M, Katsurabayashi S, Shirasaka Y, Okano H, Hirose S
Mol Brain, 2013;6(0):19.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Melemedjian O, Tillu D, Asiedu M, Mandell E, Moy J, Blute V, Taylor C, Ghosh S, Price T
Mol Pain, 2013;9(0):12.
Species: Mouse
Sample Type: In Vivo
Application: In Vivo
Authors: Maroof A, Keros S, Tyson J, Ying S, Ganat Y, Merkle F, Liu B, Goulburn A, Stanley E, Elefanty A, Widmer H, Eggan K, Goldstein P, Anderson S, Studer L
Cell Stem Cell, 2013;12(5):559-72.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Lundgaard I, Luzhynskaya A, Stockley J, Wang Z, Evans K, Swire M, Volbracht K, Gautier H, Franklin R, Attwell D, Karadottir R
PLoS Biol, 2013;11(12):e1001743.
Species: Rat
Sample Type: Whole Cells
Application: cell culture
Authors: Denis J, Gauthier M, Rachdi L, Aubert S, Giraud-Triboult K, Poydenot P, Benchoua A, Champon B, Maury Y, Baldeschi C, Scharfmann R, Pietu G, Peschanski M, Martinat C
J Cell Sci, 2013;126(0):1763-72.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Zhong C, Talmage D, Role L
PLoS ONE, 2013;8(12):e82719.
Species: Mouse
Sample Type: Whole Tissue
Application: Bioassay
Authors: Corbett, Grant T, Roy, Avik, Pahan, Kalipada
J Biol Chem, 2013;288(12):8299-312.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Authors: Makino, Kenichi, Kawamura, Kazuhiro, Sato, Wataru, Kawamura, Nanami, Fujimoto, Toshio, Terada, Yukihiro
PLoS ONE, 2012;7(7):e41049.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Moore RN, Cherry JF, Mathur V
Stem Cells Dev., 2012;21(1):30-41.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Castonguay R, Werner ED, Matthews RG, Presman E, Mulivor AW, Solban N, Sako D, Pearsall RS, Underwood KW, Seehra J, Kumar R, Grinberg AV
J. Biol. Chem., 2011;286(34):30034-46.
Species: Human
Sample Type: Recombinant Protein
Application: Surface Plasmon Resonance
Authors: Whitfield TW, Shi X, Sun WL
J. Neurosci., 2011;31(3):834-42.
Species: Rat
Sample Type: In Vivo
Application: In Vivo
Authors: Ruiz de Almodovar C, Coulon C, Salin PA, Knevels E, Chounlamountri N, Poesen K, Hermans K, Lambrechts D, Van Geyte K, Dhondt J, Dresselaers T, Renaud J, Aragones J, Zacchigna S, Geudens I, Gall D, Stroobants S, Mutin M, Dassonville K, Storkebaum E, Jordan BF, Eriksson U, Moons L, D'Hooge R, Haigh JJ, Belin MF, Schiffmann S, Van Hecke P, Gallez B, Vinckier S, Chedotal A, Honnorat J, Thomasset N, Carmeliet P, Meissirel C
J. Neurosci., 2010;30(45):15052-66.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Authors: Delcroix GJ, Curtis KM, Schiller PC, Montero-Menei CN
Differentiation, 2010;80(4):213-27.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
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製品情報は掲載時点のものですが、価格表内の価格については随時最新のものに更新されます。お問い合わせいただくタイミングにより製品情報・価格などは変更されている場合があります。
表示価格に、消費税等は含まれていません。一部価格が予告なく変更される場合がありますので、あらかじめご了承下さい。