ErbB2/Her2 Fc Chimera Protein, CF 組換え体(リコンビナント)タンパク質 | Recombinant Human ErbB2/Her2 Fc Chimera Protein, CF
掲載日情報：2018/02/07 現在Webページ番号：215965
R&D Systems社製の高品質なErbB2/Her2 Fc Chimera Protein, CFの組換え体タンパク質(Recombinant Human ErbB2/Her2 Fc Chimera Protein, CF)です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 ：2025年08月02日 20時35分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
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[在庫・価格 ：2025年08月02日 20時35分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
Recombinant Human ErbB2/Her2 Fc Chimera Protein, CF
文献数： 0
- 商品コード：1129-ER-01M
- メーカー：RSD
- 包装：1mg
- 価格：ご照会ください
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | 純度：>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.，由来動物：Human，M.W.：96.8 kDa (monomer)，Genbank：2064，エンドトキシンレベル：<0.10 EU per 1 µg of the protein by the LAL method.，産生：NS0 別名：CD340 Genbank No： 2064 Protein Accession No： NP_004439 |
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| 保存条件 | -20℃ | 法規備考 | |
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CF(Carrier-Free)とは？
R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。
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Product Details
- Source
- Mouse myeloma cell line, NS0-derivedHuman Erb B2(Thr23-Thr652)Accession # NP_004439IEGRMDHuman IgG1(Pro100-Lys330)6 His-tagN-terminusC-terminus
- Accession #
- NP_004439
- Purity
- >90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
- Predicted Molecular Mass
- 96.8 kDa (monomer)
- SDS-PAGE
- 125-130 kDa, reducing conditions220-250 kDa, non-reducing conditions
- Activity
- Measured by its ability to block anti-ErbB2 mediated inhibition of SK‑BR‑3 human breast cancer cell proliferation. Brodowicz, T. et al. (1997) Int. J. Cancer 73:875. The ED50 for this effect is 20-80 ng/mL in the presence of 0.6 µg/mL GoatAnti-Human ErbB2/Her2 Antigen Affinity-purified Polyclonal Antibody(Catalog # AF1129).
- Bioactivity
- Recombinant Human ErbB2/Her2 Fc Chimera (Catalog # 1129-ER) blocks anti-ErbB2 mediated inhibition of the SK‑BR‑3 human breast cancer cell line. The ED50 is 20-80 ng/mL in the presence of 0.6 μg/mL Goat Anti-Human ErbB2/Her2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1129)
- SDS-PAGE
- 1 μg/lane of Recombinant Human ErbB2 Fc Chimera was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by silver staining, showing major bands at 125-130 kDa and 220-250 kDa, respectively.
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Related Product & Information
- Entrez Gene IDs
- 2064 (Human); 13866 (Mouse); 24337 (Rat)
- Background
- ErbB2/Her2
- ErbB2, also called Neu and Her2 (human epidermal growth factor receptor 2), is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors. ErbB family members serve as receptors for the epidermal growth factor (EGF) family of growth factors. ErbB2 is widely expressed in epithelial cells and has also been found to be over-expressed in a large number of breast carcinomas. Among ErbB family members, ErbB2 is unique in that it has no identified ligands. Rather, ErbB2 heterodimerizes with the other members of the ErbB family (ErbB1 (EGFR), ErbB3, ErbB4) to form higher affinity signaling complexes. Because ErbB3 contains a defective kinase domain, the kinase domain of ErbB2 is responsible for initiating the tyrosine phosphorylation signal through the heterodimeric receptor. It has been found that a discrete three amino acid signal in the ErbB3 cytoplasmic domain is critical for transactivation of ErbB2. Interestingly, this same three amino acid signal has also been found in ErbB1 and ErbB4. Phosphoinositide 3-kinase has been shown to play a role in ErbB2 signal transduction. The cytoplasmic domain of ErbB2 has been shown to associate with beta-catenin and plakoglobin. Human ErbB2 consists of 1255 amino acids (aa) with a 21 aa signal sequence, a 631 aa extracellular domain, a 23 aa transmembrane region, and a 580 aa cytoplasmic domain. ErbB2 can be shed from the cell surface by proteolytic cleavage by an unidentified protease. ErbB2 appears to play roles in development, cancer, communication at the neuromuscular junction and regulation of cell growth and differentiation (1-10).
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Citations
R&D Systems personnel manually curate a database that contains references using R&D Systems products.
The data collected includes not only links to publications in PubMed,
but also provides information about sample types, species, and experimental conditions.
The data collected includes not only links to publications in PubMed,
but also provides information about sample types, species, and experimental conditions.
Efficient generation of single domain antibodies with high affinities and enhanced thermal stabilities
Authors: N Shinozaki, R Hashimoto, K Fukui, S Uchiyama
Sci Rep, 2017;7(1):5794.
Species: N/A
Sample Type: Proteins
Application: Bioassay
Authors: N Shinozaki, R Hashimoto, K Fukui, S Uchiyama
Sci Rep, 2017;7(1):5794.
Species: N/A
Sample Type: Proteins
Application: Bioassay
A High-Affinity Repebody for Molecular Imaging of EGFR-Expressing Malignant Tumors
Authors: M Yun, DY Kim, JJ Lee, HS Kim, HS Kim, A Pyo, Y Ryu, TY Kim, JH Zheng, SW Yoo, H Hyun, G Oh, J Jeong, M Moon, JH Min, SY Kwon, JY Kim, E Chung, Y Hong, W Lee, HS Kim, JJ Min
Theranostics, 2017;7(10):2620-2633.
Species: N/A
Sample Type: Recombinant Protein
Application: ELISA development
Authors: M Yun, DY Kim, JJ Lee, HS Kim, HS Kim, A Pyo, Y Ryu, TY Kim, JH Zheng, SW Yoo, H Hyun, G Oh, J Jeong, M Moon, JH Min, SY Kwon, JY Kim, E Chung, Y Hong, W Lee, HS Kim, JJ Min
Theranostics, 2017;7(10):2620-2633.
Species: N/A
Sample Type: Recombinant Protein
Application: ELISA development
Insertion of a ligand to HER2 in gB retargets HSV tropism and obviates the need for activation of the other entry glycoproteins
Authors: B Petrovic, T Gianni, V Gatta, G Campadelli
PLoS Pathog., 2017;13(4):e1006352.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: B Petrovic, T Gianni, V Gatta, G Campadelli
PLoS Pathog., 2017;13(4):e1006352.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Enhanced and long term immunogenicity of a Her-2/neu multi-epitope vaccine conjugated to the carrier CRM197 in conjunction with the adjuvant Montanide
Authors: J Tobias, J Jasinska, K Baier, M Kundi, N Ede, C Zielinski, U Wiedermann
BMC Cancer, 2017;17(1):118.
Species: Mouse
Sample Type: Serum
Application: Bioassay
Authors: J Tobias, J Jasinska, K Baier, M Kundi, N Ede, C Zielinski, U Wiedermann
BMC Cancer, 2017;17(1):118.
Species: Mouse
Sample Type: Serum
Application: Bioassay
A Highly Diverse and Functional Na�ve Ubiquitin Variant Library for Generation of Intracellular Affinity Reagents
J. Mol. Biol., 2016;0(0):.
Species: Human
Sample Type: Protein
Application: DirELISA
J. Mol. Biol., 2016;0(0):.
Species: Human
Sample Type: Protein
Application: DirELISA
Pegylated Trastuzumab Fragments Acquire an Increased in Vivo Stability but Show a Largely Reduced Affinity for the Target Antigen
Authors: F Selis, G Focà, A Sandomenic, C Marra, C Di Mauro, G Saccani Jo, S Scaramuzza, A Politano, R Sanna, M Ruvo, G Tonon
Int J Mol Sci, 2016;17(4):.
Species: Human
Sample Type: Recombinant Protein
Application: ELISA capture
Authors: F Selis, G Focà, A Sandomenic, C Marra, C Di Mauro, G Saccani Jo, S Scaramuzza, A Politano, R Sanna, M Ruvo, G Tonon
Int J Mol Sci, 2016;17(4):.
Species: Human
Sample Type: Recombinant Protein
Application: ELISA capture
The adjuvant effects of high-molecule-weight polysaccharides purified from Antrodia cinnamomea on dendritic cell function and DNA vaccines.
Authors: Lin C, Pan I, Li Y, Pan Y, Lin M, Lu Y, Wu H, Chu C
PLoS ONE, 2015;10(2):e0116191.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Authors: Lin C, Pan I, Li Y, Pan Y, Lin M, Lu Y, Wu H, Chu C
PLoS ONE, 2015;10(2):e0116191.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
A novel antibody engineering strategy for making monovalent bispecific heterodimeric IgG antibodies by electrostatic steering mechanism.
Authors: Liu Z, Leng E, Gunasekaran K, Pentony M, Shen M, Howard M, Stoops J, Manchulenko K, Razinkov V, Liu H, Fanslow W, Hu Z, Sun N, Hasegawa H, Clark R, Foltz I, Yan W
J Biol Chem, 2015;290(12):7535-62.
Species: Human
Sample Type: Recombinant Protein
Application: ELISA development
Authors: Liu Z, Leng E, Gunasekaran K, Pentony M, Shen M, Howard M, Stoops J, Manchulenko K, Razinkov V, Liu H, Fanslow W, Hu Z, Sun N, Hasegawa H, Clark R, Foltz I, Yan W
J Biol Chem, 2015;290(12):7535-62.
Species: Human
Sample Type: Recombinant Protein
Application: ELISA development
Selective inhibition of tumor growth by clonal NK cells expressing an ErbB2/HER2-specific chimeric antigen receptor.
Authors: Schonfeld K, Sahm C, Zhang C, Naundorf S, Brendel C, Odendahl M, Nowakowska P, Bonig H, Kohl U, Kloess S, Kohler S, Holtgreve-Grez H, Jauch A, Schmidt M, Schubert R, Kuhlcke K, Seifried E, Klingemann H, Rieger M, Tonn T, Grez M, Wels W
Mol Ther, 2015;23(2):330-8.
Species: Human
Sample Type: Whole Cells
Application: Flow
Authors: Schonfeld K, Sahm C, Zhang C, Naundorf S, Brendel C, Odendahl M, Nowakowska P, Bonig H, Kohl U, Kloess S, Kohler S, Holtgreve-Grez H, Jauch A, Schmidt M, Schubert R, Kuhlcke K, Seifried E, Klingemann H, Rieger M, Tonn T, Grez M, Wels W
Mol Ther, 2015;23(2):330-8.
Species: Human
Sample Type: Whole Cells
Application: Flow
Neural Stem Cells Secreting Anti-HER2 Antibody Improve Survival in a Preclinical Model of HER2 Overexpressing Breast Cancer Brain Metastases.
Authors: Kanojia D, Balyasnikova I, Morshed R, Frank R, Yu D, Zhang L, Spencer D, Kim J, Han Y, Yu D, Ahmed A, Aboody K, Lesniak M
Stem Cells, 2015;33(10):2985-94.
Species: Human
Sample Type: Cell Culture Supernates
Application: Bioassay
Authors: Kanojia D, Balyasnikova I, Morshed R, Frank R, Yu D, Zhang L, Spencer D, Kim J, Han Y, Yu D, Ahmed A, Aboody K, Lesniak M
Stem Cells, 2015;33(10):2985-94.
Species: Human
Sample Type: Cell Culture Supernates
Application: Bioassay
Exclusive Transduction of Human CD4+ T Cells upon Systemic Delivery of CD4-Targeted Lentiviral Vectors.
Authors: Zhou Q, Uhlig K, Muth A, Kimpel J, Levy C, Munch R, Seifried J, Pfeiffer A, Trkola A, Coulibaly C, von Laer D, Wels W, Hartwig U, Verhoeyen E, Buchholz C
J Immunol, 2015;195(5):2493-501.
Species: Human
Sample Type: Whole Cells
Application: Flow
Authors: Zhou Q, Uhlig K, Muth A, Kimpel J, Levy C, Munch R, Seifried J, Pfeiffer A, Trkola A, Coulibaly C, von Laer D, Wels W, Hartwig U, Verhoeyen E, Buchholz C
J Immunol, 2015;195(5):2493-501.
Species: Human
Sample Type: Whole Cells
Application: Flow
T Cells Engineered With Chimeric Antigen Receptors Targeting NKG2D Ligands Display Lethal Toxicity in Mice.
Authors: VanSeggelen H, Hammill J, Dvorkin-Gheva A, Tantalo D, Kwiecien J, Denisova G, Rabinovich B, Wan Y, Bramson J
Mol Ther, 2015;23(10):1600-10.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Authors: VanSeggelen H, Hammill J, Dvorkin-Gheva A, Tantalo D, Kwiecien J, Denisova G, Rabinovich B, Wan Y, Bramson J
Mol Ther, 2015;23(10):1600-10.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
A HER2-specific Modified Fc Fragment (Fcab) Induces Antitumor Effects Through Degradation of HER2 and Apoptosis.
Authors: Leung K, Batey S, Rowlands R, Isaac S, Jones P, Drewett V, Carvalho J, Gaspar M, Weller S, Medcalf M, Wydro M, Pegram R, Mudde G, Bauer A, Moulder K, Woisetschlager M, Tuna M, Haurum J, Sun H
Mol Ther, 2015;23(11):1722-33.
Species: Human
Sample Type: Recombinant Protein
Application: Bioassay
Authors: Leung K, Batey S, Rowlands R, Isaac S, Jones P, Drewett V, Carvalho J, Gaspar M, Weller S, Medcalf M, Wydro M, Pegram R, Mudde G, Bauer A, Moulder K, Woisetschlager M, Tuna M, Haurum J, Sun H
Mol Ther, 2015;23(11):1722-33.
Species: Human
Sample Type: Recombinant Protein
Application: Bioassay
Engineering of bispecific affinity proteins with high affinity for ERBB2 and adaptable binding to albumin.
Authors: Nilvebrant J, Astrand M, Georgieva-Kotseva M, Bjornmalm M, Lofblom J, Hober S
PLoS ONE, 2014;9(8):e103094.
Species: Human
Sample Type: Protein
Application: Surface Plasmon Resonance
Authors: Nilvebrant J, Astrand M, Georgieva-Kotseva M, Bjornmalm M, Lofblom J, Hober S
PLoS ONE, 2014;9(8):e103094.
Species: Human
Sample Type: Protein
Application: Surface Plasmon Resonance
Engineering multivalent antibodies to target heregulin-induced HER3 signaling in breast cancer cells.
Authors: Kang, Jeffrey, Poovassery, Jayakuma, Bansal, Pankaj, You, Sungyong, Manjarres, Isabel M, Ober, Raimund, Ward, E Sally
MAbs, 2014;6(2):340-53.
Species: N/A
Sample Type: Chip
Application: Bioassay
Authors: Kang, Jeffrey, Poovassery, Jayakuma, Bansal, Pankaj, You, Sungyong, Manjarres, Isabel M, Ober, Raimund, Ward, E Sally
MAbs, 2014;6(2):340-53.
Species: N/A
Sample Type: Chip
Application: Bioassay
Quantity and accessibility for specific targeting of receptors in tumours.
Authors: Hussain, Sajid, Rodriguez-Fernandez, Maria, Braun, Gary B, Doyle, Francis, Ruoslahti, Erkki
Sci Rep, 2014;4(0):5232.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Hussain, Sajid, Rodriguez-Fernandez, Maria, Braun, Gary B, Doyle, Francis, Ruoslahti, Erkki
Sci Rep, 2014;4(0):5232.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Identification of anti-ErbB2 dual variable domain immunoglobulin (DVD-Ig) proteins with unique activities.
Authors: Gu J, Yang J, Chang Q, Lu X, Wang J, Chen M, Ghayur T, Gu J
PLoS ONE, 2014;9(5):e97292.
Species: Human
Sample Type:
Application: Bioassay
Authors: Gu J, Yang J, Chang Q, Lu X, Wang J, Chen M, Ghayur T, Gu J
PLoS ONE, 2014;9(5):e97292.
Species: Human
Sample Type:
Application: Bioassay
An automated immunoassay for early specificity profiling of antibodies.
Authors: Frese, Katrin, Eisenmann, Meike, Ostendorp, Ralf, Brocks, Bodo, Pabst, Stefan
MAbs, 2013;5(2):279-87.
Species: Human
Sample Type: Antibody
Application: Bioassay
Authors: Frese, Katrin, Eisenmann, Meike, Ostendorp, Ralf, Brocks, Bodo, Pabst, Stefan
MAbs, 2013;5(2):279-87.
Species: Human
Sample Type: Antibody
Application: Bioassay
Synthesis of site-specific antibody-drug conjugates using unnatural amino acids.
Authors: Axup, Jun Y, Bajjuri, Krishna, Ritland, Melissa, Hutchins, Benjamin, Kim, Chan Hyu, Kazane, Stephani, Halder, Rajkumar, Forsyth, Jane S, Santidrian, Antonio, Stafin, Karin, Lu, Yingchun, Tran, Hon, Seller, Aaron J, Biroc, Sandra L, Szydlik, Aga, Pinkstaff, Jason K, Tian, Feng, Sinha, Subhash, Felding-Habermann, Brunhild, Smider, Vaughn V, Schultz, Peter G
Proc Natl Acad Sci U S A, 2012;109(40):16101-6.
Species: N/A
Sample Type:
Application: Bioassay
Authors: Axup, Jun Y, Bajjuri, Krishna, Ritland, Melissa, Hutchins, Benjamin, Kim, Chan Hyu, Kazane, Stephani, Halder, Rajkumar, Forsyth, Jane S, Santidrian, Antonio, Stafin, Karin, Lu, Yingchun, Tran, Hon, Seller, Aaron J, Biroc, Sandra L, Szydlik, Aga, Pinkstaff, Jason K, Tian, Feng, Sinha, Subhash, Felding-Habermann, Brunhild, Smider, Vaughn V, Schultz, Peter G
Proc Natl Acad Sci U S A, 2012;109(40):16101-6.
Species: N/A
Sample Type:
Application: Bioassay
Design of an optimized scaffold for affibody molecules.
Authors: Feldwisch J, Tolmachev V, Lendel C, Herne N, Sjoberg A, Larsson B, Rosik D, Lindqvist E, Fant G, Hoiden-Guthenberg I, Galli J, Jonasson P, Abrahmsen L
J. Mol. Biol., 2010;398(2):232-47.
Application: Bioassay
Authors: Feldwisch J, Tolmachev V, Lendel C, Herne N, Sjoberg A, Larsson B, Rosik D, Lindqvist E, Fant G, Hoiden-Guthenberg I, Galli J, Jonasson P, Abrahmsen L
J. Mol. Biol., 2010;398(2):232-47.
Application: Bioassay
The BMP-binding protein Crossveinless 2 is a short-range, concentration-dependent, biphasic modulator of BMP signaling in Drosophila.
Authors: Serpe M, Umulis D, Ralston A, Chen J, Olson DJ, Avanesov A, Othmer H, O'Connor MB, Blair SS
Dev. Cell, 2008;14(6):940-53.
Species: Drosophila
Sample Type: Protein
Application: Bioassay
Authors: Serpe M, Umulis D, Ralston A, Chen J, Olson DJ, Avanesov A, Othmer H, O'Connor MB, Blair SS
Dev. Cell, 2008;14(6):940-53.
Species: Drosophila
Sample Type: Protein
Application: Bioassay
Development and validation of sandwich ELISA microarrays with minimal assay interference.
Authors: Gonzalez RM, Seurynck-Servoss SL, Crowley SA
J. Proteome Res., 2008;7(6):2406-14.
Species: N/A
Sample Type: N/A
Application: ELISA Standard
Authors: Gonzalez RM, Seurynck-Servoss SL, Crowley SA
J. Proteome Res., 2008;7(6):2406-14.
Species: N/A
Sample Type: N/A
Application: ELISA Standard
Regression of experimental medulloblastoma following transfer of HER2-specific T cells.
Authors: Ahmed N, Ratnayake M, Savoldo B, Perlaky L, Dotti G, Wels WS, Bhattacharjee MB, Gilbertson RJ, Shine HD, Weiss HL, Rooney CM, Heslop HE, Gottschalk S
Cancer Res., 2007;67(12):5957-64.
Species: Human
Sample Type: Whole Cells
Application: Flow
Authors: Ahmed N, Ratnayake M, Savoldo B, Perlaky L, Dotti G, Wels WS, Bhattacharjee MB, Gilbertson RJ, Shine HD, Weiss HL, Rooney CM, Heslop HE, Gottschalk S
Cancer Res., 2007;67(12):5957-64.
Species: Human
Sample Type: Whole Cells
Application: Flow
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