MPP+ Iodide | CAS:36913-39-0

• 価格
• 構造式
• 製品情報
• 製品詳細
• 文献

価格

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構造式

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製品情報

MPP⁺ is an active metabolite of MPTP (Item No. 16377), a neurotoxin used to cause selective destruction of dopaminergic neurons in animal models of parkinsonism. MPP⁺ induces neurotoxicity primarily by inhibiting complex I of the mitochondrial electron transport chain, resulting in ATP depletion and increased oxidative stress. The key features of different neurotoxic models of Parkinson’s disease, including the MPTP model, have been detailed.

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製品詳細

name	MPP+ Iodide
Formal Name	1-methyl-4-phenyl-pyridinium, monoiodide
CAS Number	36913-39-0
Synonyms	N-Methyl-4-Phenylpyridinium Iodide
Molecular Formula	C12H12N • I
Formula Weight	297.1
Purity	≥98%
Formulation	A solid
SMILES	C[N+](C=C1)=CC=C1C2=CC=CC=C2.[I-]
InChI Code	InChI=1S/C12H12N.HI/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-10H,1H3;1H/q+1;/p-1
InChI Key	RFDFRDXIIKROAI-UHFFFAOYSA-M
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
Stability	≥ 2 years

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文献

1. Burns, R.S., Chiueh, C.C., Markey, S.P., et al. A primate model of parkinsonism: Selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Proceedings of the National Academy of Sciences of the United States of America 80(14), 4546-4550 (1983).

2. Fritz, R.R., Abell, C.W., Patel, N.T., et al. Metabolism of the neurotoxin in MPTP by human liver monoamine oxidase B. FEBS Letters 186(2), 224-228 (1985).

3. Javitch, J.A., D'Amato, R.J., Strittmatter, S.M., et al. Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: Uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity. Proceedings of the National Academy of Sciences of the United States of America 82(7), 2173-2177 (1985).

4. Goshima, Y., Misu, Y., Arai, N., et al. Nanomolar L-dopa facilitates release of dopamine via presynaptic β-adrenoceptors: Comparative studies on the actions in striatal slices from control and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated C57 black mice, an animal model for Parkinson’s disease. Japanese Journal of Pharmacology 55(1), 93-100 (1991).

5. Tieu, K. A guide to neurotoxic animal models of Parkinson’s disease. Cold Spring Harb.Perspect.Med. 1(1), (2011).

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