抗Mouse VE-Cadherin Alexa Fluor 647抗体(Anti-Mouse VE-Cadherin Alexa Fluor 647 antibody)
掲載日情報:2018/11/26 現在Webページ番号:206256
Mouse VE-Cadherin Alexa Fluor 647に対する抗体(Anti-Mouse VE-Cadherin Alexa Fluor 647 )です。
※ 本製品は研究用です。研究用以外には使用できません。
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価格
[在庫・価格 :2024年05月17日 10時35分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
詳細 | 商品名 |
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文献数 | ||
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Anti-Mouse VE-Cadherin Alexa Fluor 647 Antibody (Clone 162709) |
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[在庫・価格 :2024年05月17日 10時35分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
Anti-Mouse VE-Cadherin Alexa Fluor 647 Antibody (Clone 162709)
文献数: 0
- 商品コード:FAB1002R-100UG
- メーカー:RSD
- 包装:100μg
- 価格:¥87,000
- 在庫:無(未発注)
- 納期:10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
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Product Details
Species Reactivity | Mouse |
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Label | Alexa Fluor 647 |
Immunogen | Mouse myeloma cell line NS0-derived recombinant mouse VE-CadherinAsp46-Gln592 (Gly67 del, Ile69Asp, Lys70Gln)Accession # 2208309A |
Source | Monoclonal Rat IgG2b Clone # 162709 |
Specificity | Detects mouse VE-Cadherin in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human (rh) Cadherin-8, rhCadherin-17, rhN-Cadherin, recombinant mouse (rm) E-Cadherin, or rmP-Cadherin is observed. |
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Applications and Data
Recommended Concentration | Sample | |
Flow Cytometry | 0.25-1 µg/106 cells | bEnd.3 mouse endothelioma cell line |
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Related Product & Information
Background | VE-Cadherin |
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background_content | Background: VE-Cadherin The cadherin (Ca++-dependent adherence) superfamily is a large group of membrane-associated glycoproteins that engage in homotypic, calcium-dependent, cell-cell adhesion events. The superfamily can be divided into at least five major subfamilies based on molecule gene structure, and/or extracellular (EC) and intracellular domains (1-4). Subfamilies include classical/type I, atypical/type II, and desmosomal-related cadherins (1-3). VE-Cadherin (vascular endothelial cadherin; also cadherin-5 and CD144) is a 125 kDa atypical/type II subfamily cadherin. Its subfamily classification is based principally on its genomic structure, as its physical structure is notably divergent from other type II subfamily members (2, 3). Mouse VE-Cadherin is synthesized as a 784 amino acid (aa) type I transmembrane (TM) preproprotein that contains a 24 aa signal peptide, a 21 aa prosequence, a 554 aa extracellular region (ECR), a 21 aa TM segment, and a 164 aa cytoplasmic domain (5, 6). The ECR contains five Ca++-binding cadherin domains that are approximately 105 aa in length. Cadherin domains are comprised of two beta ‑sheets that are oriented like bread in a sandwich. Although complex, the N-terminal cadherin domain mediates trans interactions, while the internal domains contribute to cis multimerizations (7). Mouse VE-Cadherin ECR is 92%, 77%, and 73% aa identical to rat, human and porcine VE-Cadherin ECR, respectively. VE-Cadherin is involved in the maintenance of endothelial permeability. In this regard, VE-Cadherin does not initiate new blood vessel formation; it maintains it once formed. Thus, when VE‑Cadherin is downregulated, cells part and permeability increases (8). Notably, VEGF is known to promote vascular leakage, and apparently does so by inducing a beta ‑arrestin-dependent endocytosis of VE-Cadherin (9). Part of this effect may be mediated by VE‑Cadherin itself which is reported to increase the membrane half-life of VEGF R2 (10). VE-Cadherin acts homotypically at sites of zonula adherens. On each expressing cell, it is proposed that VE-Cadherin first forms a trimer, which then dimerizes with a trimeric counterpart in-trans. Alternatively, two cis-dimers could act in-trans to generate homotypic binding (11). In addition to cell adhesion, VE‑Cadherin also is reported to mediate TGF-beta receptor assembly. When clustered, VE‑Cadherin enhances T beta RII/T beta RI assembly into an active receptor complex on endothelial cells (12). VE-Cadherin is expressed on endothelial cells, trophoblast cells, endothelial progenitor cells and embryonic hematopoietic cells (5, 8, 13, 14). |
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