抗ST2 (human), pAb (ATTO 647N)抗体 | Anti-ST2 (human), pAb (ATTO 647N) antibody | Adipogen
掲載日情報：2017/10/30 現在Webページ番号：205300
Adipogen社の抗ST2 (human), pAb (ATTO 647N)抗体(Anti-ST2 (human), pAb (ATTO 647N) antibody)です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 ：2025年04月28日 00時00分現在]
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Anti-ST2 (human), Rabbit-Poly, ATTO 647N |
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[在庫・価格 ：2025年04月28日 00時00分現在]
Anti-ST2 (human), Rabbit-Poly, ATTO 647N
文献数： 0
- 商品コード：AG-25A-0058YTS-T100
- メーカー：KOM
- 包装：100tests
- 価格：¥81,000
- 在庫：無(未発注)
- 納期：2週間程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | 別名：Interleukin-1 Receptor-like 1，IL-1 Receptor-like 1，IL1RL1，IL-33 Receptor，Interleukin-33 Receptor Protein Accession No： Q01638 |
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| 保存条件 | 法規備考 | ||
| 抗原種 | 免疫動物 | ||
| 交差性 | Human | 適用 | ELISA,FCM,Western Blot |
| 標識 | ATTO 647N | 性状 | |
| 吸収処理 | クラス | ||
| クロナリティ | Polyclonal | フォーマット | |
| 掲載カタログ |
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| 製品記事 | Anti- ST2 antibody |
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| 関連記事 | |||
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製品説明
ST2 is a member of the Toll/IL-1 receptor family. Two forms of the protein exist, a soluble form known as ST2 and a membrane anchored form known as ST2L. The membrane form is expressed by Th2 cells and bone marrow derived mast cells, whereas the soluble form is expressed by serum-stimulated fibroblasts. It binds IL-33 and is structurally similar to IL-1R1. Type 2 innate lymphoid cells (ILC2), originally referred to as natural helper (NH) cells, are a novel target of IL-33. Lung ILC2s participate in the induction of airway inflammation in influenza virus-infected mice and papain-administrated mice. Soluble ST2 plays a role in protecting ILC2 from IL-33 stimulation and thereby maintaining them in a naïve state and might be important for the regulation of several disease. Blocking with anti-ST2 antibodies has been shown to alleviate experimental arthritis and airway inflammation. The IL-33-ST2 axis is is involved across a range of diseases including asthma, allergies, obesity and cardiac disease.
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製品情報
| Source/Host | Rabbit |
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| Immunogen/Antigen | Recombinant human soluble ST2. |
| Label/Conjugates | ATTO 647N |
| Application |
ELISA: (direct and indirect: 1:2000-1:5000) Flow Cytometry: 1/100 dilution Western Blot: (1:2000-1:5000 using ECL; suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk; suggested incubation time is 1 hour at room temperature). Optimal conditions must be determined individually for each application. Definition for 1 test: 1μl of labeled antibody in 100μl of Flow Cytometry buffer. |
| Crossreactivity | Human |
| Specificity | Recognizes endogenous ST2 by Flow Cytometry. |
| Purity Detail | Protein A-affinity purified. |
| Concentration | 1mg/ml |
| Formulation | Liquid. In PBS containing 0.02% sodium azide. |
| Other Product Data | New ATTO-fluorescent antibodies show increased photostability, outstanding brightness and intense signals. ATTO dyes are thermally stable, resistant to environmental changes and show no significant isomerization. ATTO 647N shows red fluorescence (λabs (max): 645nm, λem (max): 669nm, εmax: 120’000). |
| Product Type | Polyclonal Antibody |
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Detection of endogenous human ST2 with anti-ST2 (human), pAb (ATTO 647N) (AG-25A-0058YTS). Method: ILC2 cell line (Chemoattractant receptor-homologous molecule expressed on TH2 cells, CRTH2+) were stained with anti-ST2 (human), pAb (ATTO 647N) (1:100 in PBS + 2% FCS). The staining was analyzed by flow cytometry. |
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