Manzamine A (CAS: 104196-68-1)

• 価格
• 製品情報

価格

目次に戻る

製品情報

商品コード	AG-CN2-0438
品名	Manzamine A
分子式	C36H44N4O
分子量	548.8
CAS	104196-68-1
構造式
純度	≥98% (HPLC)
形状	Yellow oil.
別名	Keramamine A
特長	Antibiotic. Antibacterial against Gram positive and Gram negative bacteria. Exhibits chemotherapeutic activity. Blocks tumor cell invasion and restores cancer cell susceptibility to apoptosis in vitro. Uncouples vacuolar ATPases, inhibiting autophagy and tumor growth. Antimalaria, antifungal and antiviral agent. GSK-3β inhibitor. Anti-Alzheimer's agent. Decreased tau hyperphosphorylation. Anti-hyperlipidemic. Inhibits cholesterol ester formation and acyl-CoA:cholesterol acyl-transferase (ACAT) activity in vitro and decreases total cholesterol, triglycerides and LDL levels. Anti-atherosclerotic. Inhibits foam cell formation in macrophages.
文献	Four new bioactive manzamine-type alkaloids from the Philippine marine sponge Xestospongia ashmorica: R.A. Edrada, et al.; J. Nat. Prod. 59, 1056 (1996) In vivo antimalarial activity of the beta-carboline alkaloid manzamine A: K.K. Ang, et al.; Antimicrob. Agents Chemother. 44, 1645 (2000) Immune-mediated parasite clearance in mice infected with Plasmodium berghei following treatment with manzamine A: K.K. Ang, et al.; Parasitol. Res. 87, 715 (2001) Spectrofluorimetric determination of manzamine A in spiked human urine and plasma: A. Khalil, et al.; Pharmazie 58, 385 (2003) New manzamine alkaloids with activity against infectious and tropical parasitic diseases from an Indonesian sponge: K.V. Rao, et al.; J. Nat. Prod. 66, 823 (2003) New manzamine alkaloids from an Indo-Pacific sponge. Pharmacokinetics, oral availability, and the significant activity of several manzamines against HIV-I, AIDS opportunistic infections, and inflammatory diseases: M. Yousaf, et al.; J. Med. Chem. 47, 3512 (2004) Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for Alzheimer's disease: M. Hamann, et al.; J. Nat. Prod. 70, 1397 (2007) Manzamine A as a novel inhibitor of herpes simplex virus type-1 replication in cultured corneal cells: J.R. Palem, et al.; Planta Med. 77, 46 (2011) A novel activity from an old compound: Manzamine A reduces the metastatic potential of AsPC-1 pancreatic cancer cells and sensitizes them to TRAIL-induced apoptosis: E.A. Guzman, et al.; Invest. New Drugs 29, 777 (2011) Manzamine A, a marine-derived alkaloid, inhibits accumulation of cholesterol ester in macrophages and suppresses hyperlipidemia and atherosclerosis in vivo: K. Eguchi, et al.; Bioorg. Med. Chem. 21, 3831 (2013) The marine natural product manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells: G. Kallifatidis, et al.; Mar. Drugs 11, 3500 (2013) AR-A 014418 used against GSK3beta downregulates expression of hnRNPA1 and SF2/ASF splicing factors: A.K. Yadav, et al.; J. Oncol. 2014, 695325 (2014)

目次に戻る