抗STAT3 (3F5) Monoclonal抗体 | Anti-STAT3 (3F5) Monoclonal Antibody

• Bioss 社抗体製品の特長
• 価格表
• 使用例
• Background
• 製品情報

Bioss 社抗体製品の特長

• ウエスタンブロット、免疫組織化学（IHC-frozen、IHC-paraffin）、免疫蛍光（IF）、ELISAなどのアプリケーションに適した一次抗体がラインナップされています。
• 一次抗体はすべて、Protein AまたはProtein G精製されています。
• 幅広い研究分野に関連する抗体を取り揃えています。


※最新の適用、交差性情報の詳細は、下記製品情報項の「データシート」リンクをご参照ください。

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価格表

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使用例

	293T Cell lysates; probed with STAT3 (3F5) Monoclonal Antibody, unconjugated (bsm-33218M) at 1:300 overnight at 4°C followed by a conjugated secondary antibody for 60 minutes at 37°C.
	A594 Cell lysates; probed with STAT3 (3F5) Monoclonal Antibody, unconjugated (bsm-33218M) at 1:300 overnight at 4°C followed by a conjugated secondary antibody for 60 minutes at 37°C.
	HepG2 Cell lysates; probed with STAT3 (3F5) Monoclonal Antibody, unconjugated (bsm-33218M) at 1:300 overnight at 4°C followed by a conjugated secondary antibody for 60 minutes at 37°C.

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Background

Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:12359225, PubMed:12873986, PubMed:15194700, PubMed:17344214, PubMed:18242580, PubMed:23084476). Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:17344214). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986). Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genesPubMed:12359225. Activated by IL31 through IL31RA (PubMed:15194700). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4+ T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity (PubMed:28065600). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (PubMed:23084476).

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製品情報

name	STAT3 (3F5) Monoclonal Antibody
datasheet	最新のデータシートはこちらをご確認ください
Conjugation	Unconjugated
Gene ID	6774
Swiss Prot	P40763
Purification	Purified by Protein G.
Synonyms	Signal transducer and activator of transcription 3; STAT3; Acute-phase response factor; APRF

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