抗Mouse DEC-205/CD205 Allophycocyanin抗体(Anti-Mouse DEC-205/CD205 Allophycocyanin antibody)

• 価格
• Product Details
• Applications and Data
• Related Product & Information

価格

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Product Details

Species Reactivity	Mouse
Label	Allophycocyanin
Immunogen	E. coli-derived recombinant mouse DEC-205/CD205Cys216-Pro503Accession # Q60767
Source	Monoclonal Rat IgG2B Clone # 561118
Purification	Protein A or G purified from hybridoma culture supernatant
Specificity	Detects mouse DEC-205/CD205 in direct ELISAs.

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Applications and Data

	Recommended Concentration	Sample
Flow Cytometry	10 µL/106 cells	See below

Flow Cytometry
	Detection of DEC‑205/CD205 in Mouse Lymph Node-derived CD11c+ CD8low Cells by Flow Cytometry. Mouse lymph node-derived CD11c+ CD8low cells were stained with Rat Anti-Mouse DEC‑205/CD205 APC‑conjugated Monoclonal Antibody (Catalog # FAB5975A, filled histogram) or isotype control antibody (Catalog # IC013A, open histogram). View our protocol for Staining Membrane-associated Proteins.

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Related Product & Information

Entrez Gene IDs	4065 (Human)
Background	DEC-205/CD205
background_content	Background: DEC-205/CD205 DEC-205 (Dendritic and thymic Epithelial Cell-205; also Ly-75 and CD205) is a 200-205 kDa member of the mannose receptor family of molecules. In mouse, it is widely expressed, being found on B cells, Langerhans cells, bone marrow-derived dendritic cells, neutrophils, plus respiratory, intestinal, and thymic cortical epithelium. DEC-205 serves as a recognition/endocytic receptor for dying cells, and likely participates in the induction of self-tolerance. Mature mouse DEC-205 is a 1696 amino acid (aa) type I transmembrane glycoprotein (aa 28-1723). It contains a 1640 aa extracellular domain (ECD) (aa 28-1667) and a 31 aa cytoplasmic tail. The ECD is highly modular, containing a ricin B-type lectin domain (aa 33-182), a FN type II domain (aa 164-211) and nine sequential C-type lectin domains (aa 225-1662). There are at least two potential isoform variants. One shows a two aa substitution for aa 866-1723, and another shows a 64 aa substitution for aa 734-1723. Over aa 216-503, mouse DEC-205 shares 87% and 79% aa identity with rat and human DEC-205, respectively.

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