抗Mouse JAM-C Allophycocyanin抗体(Anti-Mouse JAM-C Allophycocyanin antibody)

掲載日情報:2018/11/26 現在Webページ番号:195714

Mouse JAM-C Allophycocyaninに対する抗体(Anti-Mouse JAM-C Allophycocyanin )です。
本製品は研究用です。研究用以外には使用できません。

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納期 文献数
Anti-Mouse JAM-C Allophycocyanin MAb (Clone 209628)
10日程度 ※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。 1
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説明文
別名:CD323
クローン:209628
Genbank No: 83700
Protein Accession No: Q9D8B7
法規制等
保存条件 法規備考
抗原種 免疫動物 Rat クラス IgG 標識 APC
交差性 Mouse 適用 FCM
クロナリティ Monoclonal フォーマット 性状 Protein A/G Affinity Purified 吸収処理
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[在庫・価格 :2024年06月09日 00時00分現在]

※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。

Anti-Mouse JAM-C Allophycocyanin MAb (Clone 209628)

文献数: 1

説明文 別名:CD323
クローン:209628
Genbank No: 83700
Protein Accession No: Q9D8B7
法規制等
保存条件 法規備考
抗原種 免疫動物 Rat
交差性 Mouse 適用 FCM
標識 APC 性状 Protein A/G Affinity Purified
吸収処理 クラス IgG
クロナリティ Monoclonal フォーマット
掲載カタログ

製品記事
関連記事



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Product Details

Species ReactivityMouse
LabelAllophycocyanin
ImmunogenMouse myeloma cell line NS0-derived recombinant mouse JAM‑C (CD323)Val32-Asn241Accession # Q9D8B7
SourceMonoclonal Rat IgG2B Clone # 209628
PurificationProtein A or G purified from hybridoma culture supernatant
SpecificityDetects mouse JAM-C (CD323) in flow cytometry.


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Applications and Data

 Recommended
Concentration
Sample
Flow Cytometry10 µL/106 cellsSee below


Flow Cytometry
Detection of JAM‑C (CD323) in B16‑F1 Mouse Cell Line by Flow Cytometry.
B16‑F1 mouse melanoma cell line was stained with Rat Anti-Mouse JAM‑C (CD323) APC‑conjugated Monoclonal Antibody (Catalog # FAB7050A, filled histogram) or isotype control antibody (Catalog # IC013A, open histogram). View our protocol for Staining Membrane-associated Proteins.


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Related Product & Information

Long NameJunctional Adhesion Molecule C
BackgroundJAM-C
background_contentBackground:
JAM-C
JAM-C (Junctional Adhesion Molecule-C), also known as JAM-3 and JAM-2, is a 40-45 kDa member of the JAM family, IgSF of molecules. It is a type I transmembrane glycoprotein that is further classified as a classical JAM with a short cytoplasmic tail vs. non-classical JAMs that contain long cytoplasmic tails. Mature mouse JAM-C is 289 amino acids (aa) in length, and contains a 212 aa extracellular region. This region possesses one N-terminal V-type and one C2-type Ig-like domain (aa 30-241). In human, JAM-C is perhaps best known as a component of the epithelial cell tight junction. In concert with two other transmembrane protein types (claudins and occludin) in-cis, JAM-C forms an intercellular barrier complex that restricts paracellular permeability. In mouse, however, this application may not apply, as endothelium, rather than epithelium, appears to be site of maximum expression. In this locale, JAM-C is suggested to regulate neutrophil exodus from the blood, and provide a barrier against reverse migration back into the vasculature. In any event, binding partners for JAM-C in-trans include JAM-B, Mac-1, alpha x beta 2 and JAM-C itself. Cells known to express JAM-C in mouse do not necessarily mirror those expressing JAM-C in human. Mouse cells known to contain JAM-C are limited in type and include endothelium, high endothelial venules, fibroblasts, hematopoietic stem cells, Schwann cells involved in myelination, and neurons of an Aδ (or pain sensing) phenotype. The extracellular domain of mouse JAM-C shares 96% and 87% aa sequence identity with the extracellular domains of rat and human JAM-C, respectively.


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Citations

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
  1. Function of Jam-B/Jam-C interaction in homing and mobilization of human and mouse hematopoietic stem and progenitor cells.
    Authors: Arcangeli M, Bardin F, Frontera V, Bidaut G, Obrados E, Adams R, Chabannon C, Aurrand-Lions M
    Stem Cells, 2014;32(4):1043-54.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow



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