抗Human BMPR-IB/ALK-6 Phycoerythrin抗体(Anti-Human BMPR-IB/ALK-6 Phycoerythrin antibody)

• 価格
• Product Details
• Applications and Data
• Related Product & Information
• Citations

価格

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Product Details

Species Reactivity	Human
Label	Phycoerythrin
Immunogen	Mouse myeloma cell line NS0-derived recombinant human BMPR‑IB/ALK‑6Lys14-Arg126Accession # O00238
Source	Monoclonal Mouse IgG2B Clone # 477914
Purification	Protein A or G purified from hybridoma culture supernatant
Specificity	Detects human BMPR‑IB/ALK‑6 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant mouse BMPR-IB is observed.

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Applications and Data

	Recommended Concentration	Sample
Flow Cytometry	10 µL/106 cells	See below

Flow Cytometry
	Detection of BMPR‑IB/ALK‑6 in PC‑3 Human Cell Line by Flow Cytometry. PC‑3 human prostate cancer cell line was stained with Mouse Anti-Human BMPR‑IB/ALK‑6 PE‑conjugated Monoclonal Antibody (Catalog # FAB5051P, filled histogram) or isotype control antibody (Catalog # IC0041P, open histogram). View our protocol for Staining Membrane-associated Proteins.

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Related Product & Information

Background

BMPR-IB/ALK-6

background_content

Background: BMPR-IB/ALK-6 Cellular responses to bone morphogenetic proteins (BMPs) have been shown to be mediated by the formation of hetero-oligomeric complexes of the type I and type II serine/threonine kinase receptors. BMP receptor IB (BMPR-IB), also known as activin receptor-like kinase (ALK)-6, is one of seven known type I serine/threonine kinases that are required for the signal transduction of TGF-beta family cytokines. In contrast to the TGF-beta receptor system in which the type I receptor does not bind TGF-beta in the absence of the type II receptor, type I receptors involved in BMP signaling (including BMPR-IA, BMPR-IB/ALK-6, and ActR-I/ALK-2) can independently bind the various BMP family proteins in the absence of type II receptors. Recombinant soluble BMPR-IB binds BMP-4 with high-affinity in solution and is a potent BMP-4 antagonist in vitro. BMPR-IB is expressed in various tissues during embryogenesis. In adult tissues, BMPR-IB is only found in the brain. The extracellular domain of BMPR-IB shares little amino acid sequence identity with the other mammalian ALK type I receptor kinases, but the cysteine residues are conserved. Human and mouse BMPR-IB are highly conserved and share 98% amino acid sequence identity.

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Citations

1. Activation of Activin receptor-like kinases curbs mucosal inflammation and proliferation in chronic rhinosinusitis with nasal polyps
   Authors: L Tengroth, J Arebro, O Larsson, C Bachert, SK Georén, LO Cardell
   Sci Rep, 2018;8(1):1561.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


2. A Selective Cell Population From Dermis Strengthens Bone Regeneration
   Stem Cells Transl Med, 2016;0(0):.
   Species: Human
   Sample Type: Whole Cells
   Application: Cell selection


3. Bone morphogenetic protein receptor IB as a marker for enrichment of osteogenic precursor-like cells in human dermis.
   Authors: He J, Dong J, Wang T
   Arch. Dermatol. Res., 2011;303(8):581-90.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow

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