抗Human Langerin/CD207 Phycoerythrin抗体(Anti-Human Langerin/CD207 Phycoerythrin antibody)
掲載日情報:2018/11/26 現在Webページ番号:195372
Human Langerin/CD207 Phycoerythrinに対する抗体(Anti-Human Langerin/CD207 Phycoerythrin )です。
※ 本製品は研究用です。研究用以外には使用できません。
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価格
[在庫・価格 :2024年05月22日 00時00分現在]
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Anti-Human Langerin/CD207 Phycoerythrin MAb (Clone 343828) |
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[在庫・価格 :2024年05月22日 00時00分現在]
Anti-Human Langerin/CD207 Phycoerythrin MAb (Clone 343828)
文献数: 2
- 商品コード:FAB2088P
- メーカー:RSD
- 包装:100tests
- 本製品は取扱中止になりました
説明文 |
クローン:343828 |
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法規制等 | |||
保存条件 | 法規備考 | ||
抗原種 | Human | 免疫動物 | Mouse |
交差性 | Human | 適用 | FCM |
標識 | PE | 性状 | |
吸収処理 | クラス | IgG | |
クロナリティ | フォーマット | ||
掲載カタログ |
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製品記事 |
Human IFN-gamma/IL-17 Dual Color ELISpot Kit |
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関連記事 |
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Product Details
Species Reactivity | Human |
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Label | Phycoerythrin |
Immunogen | Mouse myeloma cell line NS0-derived recombinant human Langerin/CD207Tyr64-Pro328Accession # Q9UJ71 |
Source | Monoclonal Mouse IgG1 Clone # 343828 |
Purification | Protein A or G purified from hybridoma culture supernatant |
Specificity | Detects human Langerin/CD207 in direct ELISAs and Western blots. |
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Applications and Data
Recommended Concentration | Sample | |
Flow Cytometry | 10 µL/106 cells | See below |
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Related Product & Information
Background | Langerin/CD207 |
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background_content | Background: Langerin/CD207 Langerin (also known as CD207) is a type II transmembrane glycoprotein which is member K of the C-type lectin domain family 4 (1). Langerin is used as a marker for Langerhans cells (LCs) which represent the immature dendritic cells in the epidermis (1, 2). LCs uniquely contain “tennis racket”-shaped endosomal recycling compartment subdomains with pentalamellar membranes termed Birbeck granules (1‑3). Langerin is necessary and sufficient for Birbeck granule formation (1). The 328 amino acid (aa) human langerin sequence contains a 43 aa cytoplasmic domain, a 21 aa transmembrane domain and a 264 aa extracellular domain (ECD) that contains a coiled-coil domain and a single C-type lectin domain. Trimerization greatly increases the lectin binding affinity (4). Langerin internalizes endogenous proteins such as type I procollagen. Internalization by LC is thought to lead to suppression of self reactions (4‑6). Langerin also mediates endocytosis of non‑peptide antigens containing mannose, N-acetyl glucosamine and fucose that are expressed by mycobacteria and fungae (4, 7). Some antigens, such as the Mycobacterium leprae glycolipid arabinomycolate, are ultimately presented by human LC CD1a in cutaneous-draining lymph nodes (8). Langerin performs a barrier-like function to HIV-1 transmission due to its internalization of virus particles for destruction (9). A rare human polymorphism within the lectin domain, W264R, abolishes both carbohydrate recognition and Birbeck granule formation (10, 11). Genetic deletion of mouse langerin was not shown to have functional consequence other than abolishing Birbeck granule formation (12). Human langerin shares 68%, 62%, 71% aa identity with mouse, rat and bovine langerin ECD, respectively. |
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Citations
- Severe dermatitis with loss of epidermal Langerhans cells in human and mouse zinc deficiency.
Authors: Kawamura T, Ogawa Y, Nakamura Y
J. Clin. Invest., 2012;122(2):722-32.
Species: Human
Sample Type: Whole Tissue
Application: IHC Frozen - Transcutaneous immunization as preventative and therapeutic regimens to protect against experimental otitis media due to nontypeable Haemophilus influenzae.
Authors: Novotny LA, Clements JD, Bakaletz LO
Mucosal Immunol, 2011;4(4):456-67.
Species: Chinchilla
Sample Type: Whole Cells
Application: Flow
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