抗Human ErbB4 Allophycocyanin抗体(Anti-Human ErbB4 Allophycocyanin antibody)

掲載日情報:2018/11/26 現在Webページ番号:195255

Human ErbB4 Allophycocyaninに対する抗体(Anti-Human ErbB4 Allophycocyanin )です。
本製品は研究用です。研究用以外には使用できません。

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[在庫・価格 :2024年05月18日 08時55分現在]

※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
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納期 文献数
Anti-Human ErbB4 Allophycocyanin MAb (Cl 182818) (100 TESTS)
10日程度 ※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。 2
説明文
別名:avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4
クローン:182818
Genbank No: 2066
Protein Accession No: Q15303
法規制等
保存条件 4℃,暗所保存,凍結禁止 法規備考
抗原種 Human 免疫動物 Mouse クラス IgG 標識 APC
交差性 Human 適用 FCM
クロナリティ Monoclonal フォーマット 性状 Protein A/G Affinity Purified 吸収処理
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関連記事

[在庫・価格 :2024年05月18日 08時55分現在]

※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。

Anti-Human ErbB4 Allophycocyanin MAb (Cl 182818) (100 TESTS)

文献数: 2

説明文 別名:avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4
クローン:182818
Genbank No: 2066
Protein Accession No: Q15303
法規制等
保存条件 4℃,暗所保存,凍結禁止 法規備考
抗原種 Human 免疫動物 Mouse
交差性 Human 適用 FCM
標識 APC 性状 Protein A/G Affinity Purified
吸収処理 クラス IgG
クロナリティ Monoclonal フォーマット
掲載カタログ

製品記事
関連記事



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Product Details

Species ReactivityHuman
LabelAllophycocyanin
ImmunogenMouse myeloma cell line NS0-derived recombinant human ErbB4/Her4Glu26-Arg649Accession # Q15303
SourceMonoclonal Mouse IgG2A Clone # 182818
PurificationProtein A or G purified from hybridoma culture supernatant
SpecificityDetects human ErbB4/Her4 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human (rh) EGF R, rhErbB2, or rhErbB3 is observed.


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Applications and Data

 Recommended
Concentration
Sample
Flow Cytometry10 µL/106 cellsSee below


Flow Cytometry
Detection of ErbB4/Her4 in MCF‑7 Human Cell Line by Flow Cytometry.
MCF‑7 human breast cancer cell line was stained with Mouse Anti-Human ErbB4/Her4 APC‑conjugated Monoclonal Antibody (Catalog # FAB11311A, filled histogram) or isotype control antibody (Catalog # IC003A, open histogram). View our protocol for Staining Membrane-associated Proteins.


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Related Product & Information

BackgroundErbB4/Her4
background_contentBackground:
ErbB4/Her4
ErbB4, also called Her4 (human epidermal growth factor receptor 4), is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors. ErbB family members serve as receptors for the epidermal growth factor (EGF) family of growth factors. ErbB4 is expressed in normal skeletal muscle, heart, pituitary, brain and several breast carcinomas. ErbB4 ligands include the neuregulins, beta-cellulin and heparin-binding EGF-like growth factor (HB-EGF). Monomeric ErbB4 binds its ligands with low affinity. Typically, heterodimerization with ErbB2 forms the high affinity receptor complex. However, ErbB4 has also been shown to heterodimerize with both ErbB1 and ErbB3. It has been suggested that the identity of the ligand may influence the dimerization partner. Several ErbB4 isoforms exist. Two of these differ in the presence of juxtamembrane extracellular sequences which regulate the ability of TACE (TNF-alpha converting enzyme, ADAM17) to proteolytically cleave ErbB4 from the cell surface. These isoforms exhibit tissue-specific expression. Another isoform lacks the phosphoinositide 3-kinase activation sequence present in the ErbB4 cytoplasmic domain. Human ErbB4 consists of 1308 amino acids (aa) with a 25 aa signal sequence, a 626 aa extracellular domain, a 24 aa transmembrane region, and a 633 aa cytoplasmic domain. ErbB4 appears to play important roles in neuronal development, development of the heart and cancer.


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Citations

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
  1. Phenotyping of human melanoma cells reveals a unique composition of receptor targets and a subpopulation co-expressing ErbB4, EPO-R and NGF-R.
    Authors: Mirkina I, Hadzijusufovic E, Krepler C, Mikula M, Mechtcheriakova D, Strommer S, Stella A, Jensen-Jarolim E, Holler C, Wacheck V, Pehamberger H, Valent P
    PLoS ONE, 2014;9(1):e84417.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow



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