抗Mouse CD5L Biotinylated抗体(Anti-Mouse CD5L Biotinylated antibody)

掲載日情報:2019/10/21 現在Webページ番号:195186

Mouse CD5L Biotinylatedに対する抗体(Anti-Mouse CD5L Biotinylated )です。
本製品は研究用です。研究用以外には使用できません。

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[在庫・価格 :2024年05月21日 12時35分現在]

※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
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納期 文献数
Anti-Mouse CD5L Biotinylated Affinity Purified Pab
10日程度 ※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。 1
説明文
別名:AIM
Genbank No: 922
Protein Accession No: Q9QWK4
法規制等
保存条件 -20℃ 法規備考
抗原種 Mouse 免疫動物 Goat クラス IgG 標識 Biotin
交差性 Mouse 適用 Western Blot
クロナリティ Polyclonal フォーマット 性状 Antigen Affinity Purified 吸収処理
掲載カタログ

製品記事 Human Pluripotent Cell-derived Endoderm Differentiation Kit
関連記事

[在庫・価格 :2024年05月21日 12時35分現在]

※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。

Anti-Mouse CD5L Biotinylated Affinity Purified Pab

文献数: 1

説明文 別名:AIM
Genbank No: 922
Protein Accession No: Q9QWK4
法規制等
保存条件 -20℃ 法規備考
抗原種 Mouse 免疫動物 Goat
交差性 Mouse 適用 Western Blot
標識 Biotin 性状 Antigen Affinity Purified
吸収処理 クラス IgG
クロナリティ Polyclonal フォーマット
掲載カタログ

製品記事 Human Pluripotent Cell-derived Endoderm Differentiation Kit
関連記事



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Product Details

Species ReactivityMouse
LabelBiotin
ImmunogenMouse myeloma cell line NS0-derived recombinant mouse CD5LGlu22-Val352Accession # Q9QWK4
SourcePolyclonal Goat IgG
PurificationAntigen Affinity-purified
SpecificityDetects mouse CD5L in Western blots. In Western blots, approximately 5% cross-reactivity with recombinant human CD5L is observed and less than 1% cross-reactivity with recombinant mouse CD5 is observed.


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Applications and Data

 Recommended
Concentration
Sample
Western Blot0.1 µg/mLRecombinant Mouse CD5L (Catalog # 2834-CL)


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Related Product & Information

BackgroundCD5L
background_contentBackground:
CD5L
CD5L (CD5 antigen-like), also known as Sp alpha and AIM, is a 50 kDa secreted glycoprotein that belongs to the SRCR (scavenger receptor cysteine-rich) group B family of proteins. Group B proteins are distinguished by SRCR domains that are encoded by a single exon (1‑3). The human CD5L cDNA encodes a 347 amino acid (aa) precursor that includes a 19 aa signal sequence and three SRCR domains (4, 5). Among group B proteins, CD5L is most closely related to CD5 and CD6, with which it shares 18% and 31% aa sequence identity, respectively. CD5L is upregulated in macrophages at inflammatory sites. It sustains inflammatory reactions by both increasing the phagocytic capacity of macrophages and impeding the apoptosis of local macrophages, NK cells, and T cells (6, 7). Agonists of the LXR and RXR nuclear hormone receptors induce CD5L upregulation in macrophages and reduce macrophage apoptosis (8, 9). Oxidized LDL (which acts through LXR/RXR) is taken up by macrophages, promoting their development into foam cells. The increased level of CD5L protects foam cells from apoptosis but permits more rapid cellular accumulation and atherosclerotic plaque formation (9). In activated B cells, however, the combination of CD5L and TGF-beta inhibits proliferation. The binding of CD5L to splenic B cells is increased following TGF-beta exposure, suggesting that TGF-beta increases the expression or availability of an unidentified CD5L receptor (5, 10). CD5L also functions as a pattern recognition molecule by binding both lipoteichoic acid on Gram positive and lipopolysaccharide on Gram negative bacteria (11). In the thymic cortex, CD5L protects cortical CD4+CD8+ thymocytes from apoptosis (12). CD5L circulates in the serum in complex with IgM (13).


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Citations

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
  1. CD5L/AIM Regulates Lipid Biosynthesis and Restrains Th17 Cell Pathogenicity.
    Authors: Wang C, Yosef N, Gaublomme J, Wu C, Lee Y, Clish C, Kaminski J, Xiao S, Meyer Zu Horste G, Pawlak M, Kishi Y, Joller N, Karwacz K, Zhu C, Ordovas-Montanes M, Madi A, Wortman I, Miyazaki T, Sobel R, Park H, Regev A, Kuchroo V
    Cell, 2015;163(6):1413-27.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow



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