抗Nav1.2抗体 | Anti-Nav1.2 antibody

• 特長
• 価格
• DATA IMAGES
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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DATA IMAGES

	WB analysis of rat brain membrane lysate using GTX54797 Nav1.2 antibody preincubated with or without immunogen peptide.Dilution : 1:200
	IP analysis of rat brain tissue lysate using GTX54797 Nav1.2 antibody. The lower arrow indicates the IgG heavy chain.WB was performed with the GTX54797 antibody.IP reaction : 6 μgLane 1 : Rat brain lysatesLane 2 : Lysates immunoprecipitated with Anti-SCN2A (NaV1.2) AntibodyLane 3 : Lysates immunoprecipitated with pre-immune rabbit serum
	IHC-Fr analysis of mouse hippocampus tissue using GTX54797 Nav1.2 antibody. Panel A : NaV1.2 (red) is present in dendrites of pyramidal neurons in the CA3 region. Panel B : Staining of interneurons in the pyramidal layer with mouse anti-Parvalbumin (green) demonstrates the restriction of NaV1.2 to dendrites (arrows) extending from the pyramidal layer (P). Panel C : Confocal merge of panels A and B.

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製品情報

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	WB, ICC/IF, IHC-Fr, IP
Reactivity	Human, Mouse, Rat

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APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Dilution
WB	Assay dependent
ICC/IF	Assay dependent
IHC-Fr	Assay dependent
IP	Assay dependent

Not tested in other applications.

Calculated MW	228 kDa. ( Note )

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PROPERTIES

Form	Liquid
Buffer	PBS pH 7.4, 1% BSA, 0.05% sodium azide
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration	0.8 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species	Rat
Immunogen	Peptide (C)ASAESRDFSGAGGIGVFSE, corresponding to amino acid residues 467-485 (Intracellular loop between domains I and II) of rat NaV1.2 (Accession  : P04775).
Purification	Purified by antigen-affinity chromatography
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	sodium voltage-gated channel alpha subunit 2 , NachII , Nav1.2 , RII/RIIA , RNSCPIIR , SCN , Scn2a1 , Scn2a2 , ScpII
Cellular Localization	Cell membrane
Background	Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with four repeat domains, each of which is composed of six membrane-spanning segments, and one or more regulatory beta subunits. Voltage-gated sodium channels are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. In humans, variants of this gene are associated with seizure disorders and autism spectrum disorder. Mice homozygous for a knockout mutation die with severe hypoxia and extensive neuronal cell death, while gain of function mutations result in progressive seizure disorder. [provided by RefSeq, Nov 2016]
Database	・ Gene ID: 24766 Scn2a ・ UniProt: P04775 Scn2a

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