Perampanel | CAS:380917-97-5

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Perampanel  M.Wt: 349.38
Perampanel  Formula: C23H15N3O
Perampanel  Solubility: DMSO
Perampanel  Purity: >98%
Perampanel  Storage:  Please store the product under the recommended conditions in the Certificate of Analysis.
CAS: 380917-97-5

Perampanel(E2007; ER 155055-90) is a selective noncompetitive AMPA-type glutamate receptor antagonist which has demonstrated anticonvulsant activity in experimental seizure models and antiepileptic activity in clinical trials. IC50 value:Target: AMPARPerampanel is currently in regulatory submission for partial-onset seizures associated with epilepsy.

1 . Hibi S, Ueno K, Nagato S,et al. Discovery of 2-(2-oxo-1-phenyl-5-pyridin-2-yl-1,2-dihydropyridin-3-yl)benzonitrile (perampanel): a novel, noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropanoic acid (AMPA) receptor antagonist. J Med Chem. 2012 Dec 13;55(23):10584-600.

2 . Rektor I. Perampanel, a novel, non-competitive, selective AMPA receptor antagonist as adjunctive therapy for treatment-resistant partial-onset seizures. Expert Opin Pharmacother. 2013 Feb;14(2):225-35.

3 . Owen RT. Perampanel: a novel antiepileptic for the adjunctive treatment of refractory partial onset seizures. Drugs Today (Barc). 2013 Jan;49(1):23-31.

4 . Shvarts V, Chung S. Perampanel: newly approved, novel antiepileptic medication for partial-onset seizures. Expert Rev Neurother. 2013 Feb;13(2):131-4.

5 . Perampanel: a new add-on treatment for epilepsy. Drug Ther Bull. 2013 Feb;51(2):18-20.