Mouse TSH alpha/beta Heterodimer Protein組換え体(リコンビナント)タンパク質 | Recombinant Mouse TSH alpha/beta Heterodimer Protein

R&D Systems社製の高品質なMouse TSH alpha/beta Heterodimer Proteinの組換え体タンパク質(Recombinant Mouse TSH alpha/beta Heterodimer Protein)です。

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R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。

Thyroid Stimulating Hormone (TSH), also known as Thyrotropin, is a 28 kDa heterodimer belonging to the glycoprotein hormone family. It is composed of noncovalently linked glycosylated alpha and beta  chains. The alpha  subunit (CG alpha ) is also a component of Follicle-Stimulating Hormone, Luteinizing Hormone, and Chorionic Gonadotropin. The unique beta  subunit confers the protein’s specific biological action and is responsible for the interaction with its receptor (1-3). The approximately 14 kDa mouse CG alpha subunit shares 73% and 97% amino acid (aa) sequence identity with the human and rat orthologs, respectively. The approximately 15 kDa mouse TSH beta subunit shares 89% and 92% aa sequence identity with the human and rat orthologs, respectively. Multiple isoforms of TSH with differing bioactivity and
half-lives exist due to differences in the post-translational glycosylation and sialylation modifications of its subunits (1, 4). TSH is produced and secreted by the anterior pituitary gland. Its secretion is controlled by Thyrotropin-Releasing Hormone (TRH) from the hypothalamus. TSH travels to the thyroid gland and binds to the TSH Receptor to stimulate production of Thyroxine (T4), which is converted in peripheral tissues to Triiodothyronine (T3), a more biologically potent form of the thyroid hormone (1, 4, 5). TSH secretion is also controlled by plasma T3 and T4 via a negative feedback mechanism and by the neurotransmitters dopamine and Somatostatin (4, 5). Serum TSH levels are often assessed to evaluate thyroid function (4, 5). TSH has also been shown to be produced by bone marrow and is believed to have a direct effect on skeletal homeostasis by promoting bone strength and quality (6-9). Additionally, serum TSH levels have been shown to be decreased in the elderly (10).