抗Human TrkB抗体(Anti-Human TrkB antibody)
掲載日情報:2019/10/21 現在Webページ番号:177337
Human TrkBに対する抗体(Anti-Human TrkB )です。
※ 本製品は研究用です。研究用以外には使用できません。
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価格
[在庫・価格 :2025年04月27日 00時00分現在]
詳細 | 商品名 |
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文献数 | ||
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Anti-Human TrkB MAb (Clone 75133) |
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1 | |||
Anti-Human TrkB MAb (Clone 75133) |
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1 | |||
Anti-Human TrkB MAb (Clone 75133) |
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1 | |||
[在庫・価格 :2025年04月27日 00時00分現在]
Anti-Human TrkB MAb (Clone 75133)
文献数: 1
- 商品コード:MAB397-100
- メーカー:RSD
- 包装:100μg
- 価格:¥101,000
- 在庫:無(未発注)
- 納期:10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
Anti-Human TrkB MAb (Clone 75133)
文献数: 1
- 商品コード:MAB397-500
- メーカー:RSD
- 包装:500μg
- 価格:¥232,000
- 在庫:無(未発注)
- 納期:10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
Anti-Human TrkB MAb (Clone 75133)
文献数: 1
- 商品コード:MAB397-SP
- メーカー:RSD
- 包装:25μg
- 価格:¥30,000
- 在庫:無(未発注)
- 納期:2~3週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
説明文 | ※受注発注品。形状:溶液または凍結乾燥 別名:BDNF/NT-3 growth factors receptor クローン:75133 Genbank No: 4915 Protein Accession No: Q16620 |
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別包装品 | 別包装品あり | ||||||
法規制等 | |||||||
保存条件 | -20℃ | 法規備考 | |||||
抗原種 | 免疫動物 | Mouse | |||||
交差性 | Human | 適用 | IHC,Western Blot | ||||
標識 | Unlabeled | 性状 | Protein A/G Affinity Purified | ||||
吸収処理 | クラス | IgG | |||||
クロナリティ | Monoclonal | フォーマット | |||||
掲載カタログ |
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製品記事 | 使いっきり抗体 |
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関連記事 |
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Product Details
Species Reactivity | Human |
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Label | Unconjugated |
Immunogen | Mouse myeloma cell line NS0-derived recombinant human TrkBCys32-His430Accession # Q16620 |
Source | Monoclonal Mouse IgG2B Clone # 75133 |
Purification | Protein A or G purified from hybridoma culture supernatant |
Specificity | Detects human TrkB in direct ELISAs and Western blots. In ELISAs and Western blots, no cross-reactivity with recombinant human (rh) TrkA, rhTrkC, or recombinant rat TrkA is observed. |
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Applications and Data
Recommended Concentration | Sample | |
Western Blot | 1 µg/mL | Recombinant Human TrkB Fc Chimera (Catalog # 688-TK) |
Immunohistochemistry | 8-25 µg/mL | See below |
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Related Product & Information
Background | TrkB |
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background_content | Background: TrkB The neurotrophins, including NGF, BDNF, NT-3, and NT-4/5 constitute a group of structurally related, secreted proteins that play an important role in the development and function of the nervous system. The biological activities of the neurotrophins are mediated by binding to the different members of the Trk family tyrosine kinase receptors. Three Trk family proteins, TrkA, TrkB, and TrkC, exhibiting different ligand specificities, have been identified. TrkA binds NGF, TrkB binds BDNF and NT‑4/5 and TrkC binds NT-3. All Trk family proteins share a conserved complex subdomain organization consisting of a signal peptide, two cysteine-rich domains, a cluster of three leucine-rich motifs, and two immunoglobulin-like domains in the extracellular region, as well as an intracellular region that contains the tyrosine kinase domain. Natural splice variants of the different Trks, including TrkB variants lacking the first cysteine-rich domain, the first and second or all three of the leucine-rich motifs, or the tyrosine kinase domain, have been described. The role of the different extracellular subdomains of TrkB in mediating neurotrophin binding and discrimination is currently being investigated. At the protein sequence level, human and rat TrkB are greater than 90% identical and the proteins exhibit cross-species activity. TrkB is primarily expressed in the nervous system. However, low levels of TrkB expression have also been observed in a wide variety of tissues (pancreas, kidneys, ovary) outside the nervous system. |
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Citations
- Brain-derived neurotrophic factor (BDNF)-induced tropomyosin-related kinase B (Trk B) signaling is a potential therapeutic target for peritoneal carcinomatosis arising from colorectal cancer.
Authors: Tanaka, Koji, Okugawa, Yoshinag, Toiyama, Yuji, Inoue, Yasuhiro, Saigusa, Susumu, Kawamura, Mikio, Araki, Toshimit, Uchida, Keiichi, Mohri, Yasuhiko, Kusunoki, Masato
PLoS ONE, 2014;9(5):e96410.
Species: Human
Sample Type: Whole Tissue
Application: IHC - Brain-derived neurotrophic factor is increased in serum and skin levels of patients with chronic spontaneous urticaria.
Authors: Rossing K, Novak N, Mommert S, Pfab F, Gehring M, Wedi B, Kapp A, Raap U
Clin. Exp. Allergy, 2011;41(10):1392-1399.
Species: Human
Sample Type: Whole Tissue
Application: IHC Paraffin-embedded - Modulation of neurotrophin and neurotrophin receptor expression in nasal mucosa after nasal allergen provocation in allergic rhinitis.
Authors: Raap U, Fokkens W, Bruder M, Hoogsteden H, Kapp A, Braunstahl GJ
Allergy, 2008;63(4):468-75.
Species: Human
Sample Type: Whole Cells
Application: ICC - IL-10 inhibits endothelium-dependent T cell costimulation by up-regulation of ILT3/4 in human vascular endothelial cells.
Authors: Gleissner CA, Zastrow A, Klingenberg R, Kluger MS, Konstandin M, Celik S, Haemmerling S, Shankar V, Giese T, Katus HA, Dengler TJ
Eur. J. Immunol., 2007;37(1):177-92.
Species: Human
Sample Type: Whole Cells
Application: Flow
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