抗SATB2抗体 | Anti-SATB2 Antibody

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価格

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Image

	Western Blot: SATB2 Antibody [NBP1-76912] - Mouse brain tissue lysate with SATB2 antibody at (A) 2 and (B) 4 ug/mL.
	Immunocytochemistry/Immunofluorescence: SATB2 Antibody [NBP1-76912] - Immunofluorescence of SATB2 in Human Brain cells with SATB2 antibody at 20 ug/mL.
	Immunohistochemistry-Paraffin: SATB2 Antibody [NBP1-76912] - Human brain with SATB2 antibody at 5 ug/ml.
	Chromatin Immunoprecipitation: SATB2 Antibody [NBP1-76912] - ChIP on Bcl2 promoter using rabbit IgG as control. Image from verified customer review.

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Background

Human special AT-rich sequence-binding protein-2 (SATB2) is a nuclear matrix/scaffold-associated region DNA-binding protein. Like its homolog SATB1, SATB2 selectively binds double-stranded, special AT-rich DNA sequences, but is expressed primarily in a subset of postmitotic, differentiating neurons in the neocortex. Mice deficient in SATB exhibit craniofacial abnormalities and defects in osteoblast differentiation and function. SATB2 also interacts with and enhances the activity of Runx2 and ATF4, two transcription factors that regulate osteoblast differentiation, indicating that SATB2 acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation. Recent experiments have shown that SATB2 interacts with histone deacetylase 1 and metastasis-associated protein 2, two proteins that are involved in chromatin remodeling, suggesting that SATB2 may also be involved in mediating epigenetic influences during cortical development. At least two isoforms of SATB2 are known to exist. This SATB2 antibody will not cross-react with SATB1.

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