抗Dicer抗体 | Anti-Dicer Antibody

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価格

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Image

	Immunocytochemistry/Immunofluorescence: Dicer Antibody [NBP1-71691] - Dicer antibody was tested in HeLa cells with Dylight 488 (green). Nuclei were counterstained with DAPI (blue).
	Immunohistochemistry-Paraffin: Dicer Antibody [NBP1-71691] - analysis of Dicer in paraffin embedded human colorectal cancer tissue using anti-Dicer antibody. Image from verified customer review.
	Immunohistochemistry: Dicer Antibody [NBP1-71691] - Staining of Dicer in mouse prostate using DAB with hematoxylin counterstain.

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Background

Dicer (DICER1 or double-strand-specific ribonuclease mDCR-1) belongs to RNase III family and is essential for RNA induced silencing complex (RISC) formation and it also forms a component of RISC loading complex (RLC) also known as the miRNA loading complex (miRLC) that contains - DICER1, EIF2C2/AGO2 and TARBP2. Within RLC/miRLC complex, DICER1 and TARBP2 are required to process precursor miRNAs to mature miRNAs and then load them onto EIF2C2/AGO2. Dicer also cleaves double-stranded RNA to produce short interfering RNAs (siRNAs) which targets selective destruction of complementary RNAs. siRNAs play a key roles in mitosis and DICER1 mutations have been shown to be associated with malignancies including blastoma, breast cancer, adenocarcinoma, and pancreatitis. It is also involved in myelination and other nervous system protections as well as pathologies including miRNA induced malformations of critical sensory cells in vision/hearing, cardiovascular diseases etc.

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