360A-Iodide | CAS:737763-37-0

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Name:360A iodide; 360 A iodide
Cat. No. :CS-1560
CAS No. :737763-37-0
Formula:C27H23I2N5O2
M. Wt. : 703.31
Solubility:10 mM in DMSO

360A is a strong affinity and selectivity inhibitor of G-quadruplex structures.IC50 Value:Target: G-quadruplexin vitro: We found a S-phase accumulation in ATM-proficient, but not in ATM-deficient EBV-lymphocytes treated with 360A before induction of cell death. However, ATM status did not modify cell cycle distribution in 360A-treated SV40-fibroblasts and HeLa cells compared to DMSO treated controls [1]. DNA-PKcs-dependent NHEJ was responsible for sister telomere fusions as a direct consequence of G-quadruplex formation and/or stabilization induced by 360A on parental telomere G strands. NHEJ and HR activation at telomeres altered mitotic progression in treated cells [2]. This compound was shown to display a potent affinity and selectivity for telomeric G-quadruplex DNA over duplex DNA and to induce delayed growth inhibition in HT1080 tumor cell line [3].in vivo: N/AClinical trial: N/A

Sidibe A, et al. Effects of a halogenated G-quadruplex ligand from the pyridine dicarboxamide series on the terminal sequence of XpYp telomere in HT1080 cells. Biochimie. 2012 Dec;94(12):2559-68. Gauthier LR, et al. Rad51 and DNA-PKcs are involved in the generation of specific telomere aberrations induced by the quadruplex ligand 360A that impair mitotic cell progression and lead to cell death. Cell Mol Life Sci. 2012 Feb;69(4):629-40. G Pennarun, et al. Role of ATM in the telomere response to the G-quadruplex ligand 360A. February 2008. Nucleic Acids Research, 2008, Vol. 36, No. 5 1741-1754.