CDK9-inhibitor-2 | CAS:1263369-28-3

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Name:CDK9-IN-2; 
Cat. No. :CS-1252
CAS No. :1263369-28-3
Formula:C23H25ClFN5
M. Wt. : 425.93
Solubility:10 mM in DMSO

CDK9-IN-2 is a special cyclin-dependent kinase 9 (CDK9) inhibitor, extracted from patent WO/2012131594A1, compound CDKI(8), has an IC50 of 5 nM and 7 nM in H929 multiple myeloma(MM) cell line (72 hours) and A2058 skin cell line (72 hours), respectively.IC50 & Target: IC50: 5 nM (CDK9, in H929 multiple myeloma cell line), 7 nM (CDK9, in A2058 skin cell line)[1]In Vitro: CDK9-IN-2 (200 nM) reduces the expression of MEPCE indicating that MEPCE is a pharmacodynamic (PD) marker for any CDK9 inhibitor. The expression of MCL1 protein is reduced 2 hours after treatment and is further reduced after 16 hour exposure to CDK9-IN-2 (500 nM)[1].

Michel Faure, et al. Pharmacodynamic markers associated with cyclin-dependent kinase inhibitors. From PCT Int. Appl. (2012), WO 2012131594A1.