Dexrazoxane (Hydrochloride) | CAS:149003-01-0

Chemscene社は、高品質な低分子化合物を提供しているメーカーです。
Chemscene社のDexrazoxane (Hydrochloride)(CAS:149003-01-0)をご紹介します。

※本製品は研究用です。研究用以外には使用できません。

Name:Dexrazoxane Hydrochloride; ICRF-187 hydrochloride
Cat. No. :CS-0767
CAS No. :149003-01-0
Formula:C11H17ClN4O4
M. Wt. : 304.73
Solubility:10 mM in DMSO

Dexrazoxane Hcl( ICRF-187 Hcl) is a cardioprotective agent. IC50 value:Target: cardioprotective agentAs a derivative of EDTA, dexrazoxane chelates iron, thus reduce the number of metal ions complexed with anthracycline and, consequently, decrease the formation of superoxide radicals. This agent is used to protect the heart against the cardiotoxic side effects of anthracyclines, such as doxorubicin. It was speculated that dexrazoxane could be used for further investigation to synthesize new antimalarial drugs.

Hasinoff BB. The use of dexrazoxane for the prevention of anthracycline extravasation injury. Expert Opin Investig Drugs. 2008 Feb;17(2):217-23. Lipshultz SE, Scully RE, Lipsitz SR et al. Assessment of dexrazoxane as a cardioprotectant in doxorubicin-treated children with high-risk acute lymphoblastic leukaemia: long-term follow-up of a prospective, randomised, multicentre trial. Lancet Oncol. 2010 Oct;11(10):950-61. Jones RL. Utility of dexrazoxane for the reduction of anthracycline-induced cardiotoxicity. Expert Rev Cardiovasc Ther. 2008 Nov;6(10):1311-7.