Aliskiren | CAS:173334-57-1

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Name:Aliskiren; CGP 60536; CGP60536B; SPP 100
Cat. No. :CS-0443
CAS No. :173334-57-1
Formula:C30H53N3O6
M. Wt. : 551.76
Solubility:10 mM in DMSO

Aliskiren(CGP 60536) is a direct renin inhibitor with IC50 of 1.5 nM.IC50 value: 1.5 nM [1]Target: reninin vitro: Aliskiren hemifumarate appears to bind to both the hydrophobic S1/S3-binding pocket and to a large, distinct subpocket that extends from the S3-binding site towards the hydrophobic core of renin. Oral bioavailability of Aliskiren hemifumarate is 2.4% in rats, 16% in marmosets and about 2.5% in humans [2].in vivo: Aliskiren hemifumarate (

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