Pentostatin | CAS:53910-25-1

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Name:Pentostatin; Deoxycoformycin
Cat. No. :CS-0374
CAS No. :53910-25-1
Formula:C11H16N4O4
M. Wt. : 268.27
Solubility:10 mM in DMSO

Pentostatin is an irreversible inhibitor of adenosine deaminase with Ki of 2.5 pM.IC50 & Target: Ki: 2.5 pM (adenosine deaminase)In Vivo: In ECP and Pentostatin (4 mg/m2, i.v.) treatment, all dogs develop granulocytopenia with [1]. Pentostatin (2 mg/kg) in combination with cordycepin (2 mg/kg) is 100% effective in the T. evansi-infected mice. There is an increase in levels of some biochemical parameters, especially on liver enzymes, which are accompanied by histological lesions in the liver and kidneys. Pentostatin individually has no curative effect on infected groups[2].

Dalla Rosa L, et al. Cordycepin (3'-deoxyadenosine) pentostatin (deoxycoformycin) combination treatment of mice experimentally infected with Trypanosoma evansi. Parasitology. 2013 Apr;140(5):663-71. Bethge WA, et al. Extracorporeal photopheresis combined with pentostatin in the conditioning regimen for canine hematopoietic cell transplantation does not prevent GVHD. Bone Marrow Transplant. 2014 Sep;49(9):1198-204.