抗Human STING/TMEM173 Alexa Fluor 488抗体(Anti-Human STING/TMEM173 Alexa Fluor 488 antibody)
掲載日情報：2018/11/26 現在Webページ番号：159546
Human STING/TMEM173 Alexa Fluor 488に対する抗体(Anti-Human STING/TMEM173 Alexa Fluor 488 )です。
※ 本製品は研究用です。研究用以外には使用できません。
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価格
[在庫・価格 ：2024年06月09日 00時00分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
| 詳細 | 商品名 |
|
文献数 | ||
|---|---|---|---|---|---|
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Anti-Human STING/TMEM173 Alexa Fluor 488 MAb (Clone 723505) |
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0 | |||
[在庫・価格 ：2024年06月09日 00時00分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
Anti-Human STING/TMEM173 Alexa Fluor 488 MAb (Clone 723505)
文献数： 0
- 商品コード：IC7169G-025
- メーカー：RSD
- 包装：25tests
- 価格：¥49,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
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Product Details
| Species Reactivity | Human |
|---|---|
| Label | Alexa Fluor 488 |
| Immunogen | E. coli-derived recombinant human STING/TMEM173Ala215-Ser379Accession # Q86WV6 |
| Source | Monoclonal Mouse IgG2B Clone # 723505 |
| Purification | Protein A or G purified from hybridoma culture supernatant |
| Specificity | Detects human STING/TMEM173 in direct ELISAs and Western blots. |
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Applications and Data
| Recommended Concentration | Sample | |
| Intracellular Staining by Flow Cytometry | 5 µL/106 cells | See below |
| Intracellular Staining by Flow Cytometry | |
|---|---|
 | Detection of STING/TMEM173 in Human PBMC Monocytes by Flow Cytometry. Human peripheral blood mononuclear cells (PBMC) monocytes were stained with Mouse Anti-Human STING/TMEM173 Alexa Fluor® 488‑conjugated Monoclonal Antibody (Catalog # IC7169G, filled histogram) or isotype control antibody (Catalog # IC0041G, open histogram). To facilitate intracellular staining, cells were fixed with Flow Cytometry Fixation Buffer (Catalog # FC004) and permeabilized with Flow Cytometry Permeabilization/Wash Buffer I (Catalog # FC005). View our protocol for Staining Intracellular Molecules. |
| Intracellular Staining by Flow Cytometry | |
 | Detection of STING/TMEM173 in THP‑1 Human Cell Line by Flow Cytometry. THP‑1 human acute monocytic leukemia cell line was stained with Mouse Anti-Human STING/TMEM173 Alexa Fluor® 488‑conjugated Monoclonal Antibody (Catalog # IC7169G, filled histogram) or isotype control antibody (Catalog # IC0041G, open histogram). To facilitate intracellular staining, cells were fixed with Flow Cytometry Fixation Buffer (Catalog # FC004) and permeabilized with Flow Cytometry Permeabilization/Wash Buffer I (Catalog # FC005). View our protocol for Staining Intracellular Molecules. |
| Intracellular Staining by Flow Cytometry | |
 | Detection of STING/TMEM173 in U937 Human Cell Line by Flow Cytometry. U937 human histiocytic lymphoma cell line was stained with Mouse Anti-Human STING/TMEM173 Alexa Fluor® 488‑conjugated Monoclonal Antibody (Catalog # IC7169G, filled histogram) or isotype control antibody (Catalog # IC0041G, open histogram). To facilitate intracellular staining, cells were fixed with Flow Cytometry Fixation Buffer (Catalog # FC004) and permeabilized with Flow Cytometry Permeabilization/Wash Buffer I (Catalog # FC005). View our protocol for Staining Intracellular Molecules. |
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Related Product & Information
| Long Name | Stimulator of Interferon Genes Protein/Transmembrane protein 173 |
|---|---|
| Background | STING/TMEM173 |
| background_content | Background: STING/TMEM173 STING (Stimulator of Interferon Genes), also called ERIS, MPYS, or MITA and designated TMEM173, is a 40-42 kDa 4-transmembrane protein that mediates both antiviral and MHC-II antigen recognition responses. STING is found predominantly in the endoplasmic reticulum. It acts as an adaptor protein for intracellular viral detection molecules, participating in the induction of type I interferon. It also may play a role in the initiation of apoptosis following MHC-II engagement. Cells known to express STING include B cells, dendritic cells, macrophages, and monocytes. Human STING is 379 amino acids (aa) in length. It contains an N-terminal cytoplasmic region (aa 1-20), four transmembrane segments (aa 21-173), and a C-terminal cytoplasmic domain (aa 174-379). Ubiquitination occurs at Lys150, and phosphorylation occurs at Ser358. STING forms 80 kDa homodimers. There are two potential splice forms, one that shows a 25 aa substitution for aa 1-173, and another that possesses an alternative start site at Met215, coupled to a premature truncation following Arg334. Over aa 215-379, human and mouse STING share 76% aa sequence identity. |
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