LDN 212320 (3-[[(2-Methylphenyl)methyl]thio]-6-(2-pyridinyl)-pyridazine) | 894002-50-7

name

ldn 212320

chemical name

3-[[(2-methylphenyl)methyl]thio]-6-(2-pyridinyl)-pyridazine

activity

increases expression of glutamate transporter eaat2 in pa-eaat2 cells. displays neuroprotective activity in vivo. shown to improve learning and memory, restore synaptic integrity and reduce amyloid plaque burden in appsw/ind mice.

MW

293.39

Formula:

c17h15n3s

Solubility:

soluble to 100 mm in dmso and to 20 mm in ethanol

Purity:

>98 %

Storage:

store at -20°c

CAS No:

894002-50-7

Xing et al (2011) Structure-activity relationship study of pyridazine derivatives as glutamate transporter EAAT2 activators. Bioorg.Med.Chem.Lett. 21 5774. PMID: 21875806.

Lin et al (2012) Glutamate transporter EAAT2: a new target for the treatment of neurodegenerative diseases. Future Med Chem 4 1689. PMID: 22924507.

Lin et al (2013) : Mechanism of LDN-212320 induction of glutamate transporter EAAT2 expression . Society for Neuroscience (Abstract) 99.

Takahashi et al (2013) A small molecule modulator of glutamate transporter EAAT2 ameliorates Alzheimer’s-like pathologies and memory deficits in APPSw/Ind mice. Society for Neuroscience (Abstract) 103.