LM11A 31 dihydrochloride ((2S,3S)-2-Amino-3-methyl-N-[2-(4-morpholinyl)ethyl]pentanamide dihydrochloride) | 1243259-19-9

name

lm11a 31 dihydrochloride

chemical name

(2s,3s)-2-amino-3-methyl-n-[2-(4-morpholinyl)ethyl]pentanamide dihydrochloride

activity

nonpeptide p75ntr ligand; blocks p75-mediated cell death and also increases proliferation and survival of hippocampal neural progenitors. exhibits no effect on nerve growth factor (ngf) binding to trka. prevents and reverses atrophy of cholinergic neurites, as well as reversing alzheimer's disease (ad) pathologies in mid- to late-stage ad mice models. shown to promote functional recovery in a mouse model of spinal cord injury. orally available and brain penetrant.

MW

316.27

Formula:

c12h25n3o2.2hcl

Solubility:

soluble to 100 mm in water and to 100 mm in dmso

Purity:

>98 %

Storage:

desiccate at rt

CAS No:

1243259-19-9

Massa et al (2006) Small, nonpeptide p75^NTR ligands induce survival signaling and inhibit proNGF-induced death. J.Neurosci. 26 5288. PMID: 6707781.

Shi et al (2013) A small molecule P75NTR ligand protects neurogenesis after traumatic brain injury. Stem Cells [Epub ahead of print]. PMID: 23940017.

Tep et al (2013) Oral administration of a small molecule targeted to block proNGF binding to p75 promotes myelin sparing and functional recovery after spinal cord injury. J.Neurosci. 33 397. PMID: 23303920.

Simmons et al (2014) A small molecule p75^NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression. PLoS One 9 e102136. PMID: 25153701.