PAOPA ((3R)-2-Oxo-3-[[(2S)-2-Pyrrolidinylcarbonyl]amino]-1-pyrrolidineacetamide) | 114200-31-6

name

paopa

chemical name

(3r)-2-oxo-3-[[(2s)-2-pyrrolidinylcarbonyl]amino]-1-pyrrolidineacetamide

activity

allosteric modulator of dopamine d2 receptors. prevents and reverses behavioral and biochemical abnormalities in an amphetamine-sensitized animal model of schizophrenia.

MW

254.29

Formula:

c11h18n4o3

Solubility:

soluble to 100 mm in water and to 100 mm in dmso

Purity:

>98 %

Storage:

store at -20°c

CAS No:

114200-31-6

Dyck et al (2011) PAOPA, a potent analogue of Pro-Leu-glycinamide and allosteric modulator of the dopamine D2 receptor, prevents NMDA receptor antagonist (MK-801)-induced deficits in social interaction in the rat: implications for the treatment of negative symptoms in schizophrenia. Schizophr.Res. 125 89. PMID: 21036015.

Tan et al (2011) Preclinical pharmacokinetic and toxicological evaluation of MIF-1 peptidomimetic, PAOPA: examining the pharmacology of a selective dopamine D2 receptor allosteric modulator for the treatment of schizophrenia. Peptides 42 89. PMID: 23416534.

Beyaert et al (2013) PAOPA, a potent dopamine D2 receptor allosteric modulator, prevents and reverses behavioral and biochemical abnormalities in an amphetamine-sensitized preclinical animal model of schizophrenia. Eur.Neuropsychopharmacol. 23 253. PMID: 22658400.