C 646 (4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]benzoic acid) | 328968-36-1

name

c 646

chemical name

4-[4-[[5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1h-pyrazol-1-yl]benzoic acid

activity

selective p300/creb-binding protein (cbp) inhibitor (ki = 400 nm). selective against six other histone acetyltransferases (hats). suppresses histone h3 and h4 acetylation in mouse fibroblast cell lines.

MW

445.42

Formula:

c24h19n3o6

Solubility:

soluble to 25 mm in dmso

Purity:

>98 %

Storage:

store at +4°c

CAS No:

328968-36-1

Bowers et al (2010) Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor. Chem.Biol. 17 471. PMID: 20534345.

Mali et al (2010) Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Stem Cells 28 713. PMID: 20201064.

Ott and Verdi (2010) HAT trick: p300, small molecule, inhibitor. Chem.Biol. 17 417. PMID: 20534339.

Crump et al (2011) Dynamic acetylation of all lysine-4 trimethylated histone H₃ is evolutionarily conserved and mediated by p300/CBP. Proc.Natl.Acad.Sci. USA 108 7814.