MDL 100907 ((R)-(+)-α-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperinemethanol) | 139290-65-6

name

mdl 100907

chemical name

(r)-(+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperinemethanol

activity

potent and selective 5-ht2a receptor antagonist (ki = 0.36 nm). exhibits > 80-fold selectivity for 5-ht2a over other serotonergic receptor subtypes. antipsychotic agent in vivo.

MW

373.46

Formula:

c22h28fno3

Solubility:

soluble to 50 mm in 1eq. hcl and to 100 mm in dmso

Purity:

>98 %

Storage:

store at +4°c

CAS No:

139290-65-6

Sorensen et al (1993) Characterization of the 5-HT2 receptor antagonist MDL 100907 as a putative atypical antipsychotic: behavioral, electrophysiological and neurochemical studies. J.Pharmacol.Exp.Ther. 266 684. PMID: 8102646.

Kehne et al (1996) Preclinical characterization of the potential of the putative atypical antipsychotic MDL 100,907 as a potent 5-HT2A antagonist with a favorable CNS safety profile. J.Pharmacol. 277 968. PMID: 8627580.

Ardayfio et al (2008) The 5-hydroxytryptamine_2A receptor antagonist R-(+)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl-4-piperidinemethanol (M100907) attenuates impulsivity after both drug-induced disruption (dizocilpine) and enhancement (antidepressant drugs) of differential-reinforcement-of-low-rate 72-s behavior in the rat. J.Pharmacol.Exp.Ther. 327 891. PMID: 18772320.