PSI (N-[(Phenylmethoxy)carbonyl]-L-isoleucyl-L-α-glutamyl-tert-butyl ester-N-[(1S)-1-formyl-3-methylbutyl]-L-alaninamide) | 158442-41-2

name

psi

chemical name

n-[(phenylmethoxy)carbonyl]-l-isoleucyl-l-α-glutamyl-tert-butyl ester-n-[(1s)-1-formyl-3-methylbutyl]-l-alaninamide

activity

proteasome inhibitor; inhibits chymotrypsin-like activity of the proteasome. causes dopaminergic cell death in vitro. prevents activation of nf-κb in response to tnf-α and okadaic acid (cat. no. 1136) by inhibiting iκb-α degradation. also inhibits no production by lps-activated macrophages.

MW

618.77

Formula:

c32h50n4o8

Solubility:

soluble to 30 mm in dmso

Purity:

>90 %

Storage:

store at -20°c

CAS No:

158442-41-2

Traenckner et al (1994) A proteasome inhibitor prevents activation of NF-κB and stabilizes a newly phosphorylated form of IκB-α that is still bound to NF-κB. EMBO J. 13 5433. PMID: 7957109.

Griscavage et al (1996) Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-κB. Proc.Natl.Acad.Sci.USA 93 3308.

Bukhatwa et al (2009) An immunohistochemical and stereological analysis of PSI-induced nigral neuronal degeneration in the rat. J.Neurochem. 109 52. PMID: 19187437.