TW 37 (N-[4-[[2-(1,1-Dimethylethyl)phenyl]sulfonyl]phenyl]-2,3,4-trihydroxy-5-[[2-(1-methylethyl)phenyl]methyl]benzamide) | 877877-35-5

name

tw 37

chemical name

n-[4-[[2-(1,1-dimethylethyl)phenyl]sulfonyl]phenyl]-2,3,4-trihydroxy-5-[[2-(1-methylethyl)phenyl]methyl]benzamide

activity

bcl-2 inhibitor (ki values are 0.29 μm and 1.11 μm for bcl-2 and bcl-xl respectively). inhibits the angiogenic potential of endothelial cells in vitro. induces s-phase arrest and apoptosis in pancreatic cancer cell lines; also inhibits the activation of notch-1 and jagged-1 in vitro and in vivo.

MW

573.7

Formula:

c33h35no6s

Solubility:

soluble to 100 mm in dmso

Purity:

>97 %

Storage:

store at -20°c

CAS No:

877877-35-5

Wang et al (2006) Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins. J.Med.Chem. 49 6139. PMID: 17034116.

Zeitlin et al (2006) Antiangiogenic effect of TW37, a small-molecule inhibitor of Bcl-2. Cancer Res. 66 8698. PMID: 16951185.

Ashimori et al (2009) TW-37, a small molecule inhibitor of Bcl-2, mediates S phase cell cycle arrest and suppresses head and neck tumor angiogenesis. Mol.Cancer.Ther. 8 893. PMID: 19372562.

Wang et al (2009) TW-37, a small molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer: involvement of Notch-1 signaling pathway. Cancer Res. 69 2757. PMID: 19318573.